Genotypes of human papilloma virus in Sudanese women with cervical pathology

Salih, Magdi M; Safi, Mohamed El; Hart, Keith; Tobi, Khater; Adam, Ishag

doi:10.1186/1750-9378-5-26

Cited by 24 publications

(20 citation statements)

References 17 publications

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“…Some prevalence studies have indicated that the DNA of HPV 52 is present in approximately 2% of all cases of cervical squamous intraepithelial lesions 28,29 and that the presence of HPV 58 for these lesions ranges from 6% to 20%, which is the range within which these genotypes were detected in our work 13,24,25,26 .…”

Section: Discussionsupporting

confidence: 58%

Circulation of human papillomavirus (HPV) genotypes in women from Córdoba, Argentina, with squamous intraepithelial lesions

Venezuela

Kiguen

Frutos

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYHuman papillomavirus (HPV) can induce a wide spectrum of squamous intraepithelial lesions (SIL) of varying severity. The aim of the present study was to establish the frequency of HPV infection and identify the genotypes circulating in women from Córdoba, Argentina, in relation to age and cytology. A total of 186 women, between 18 and 65 years old, with antecedents of SIL, underwent a pelvic examination and had cervical cells collected for cytology and HPV DNA detection. Ninety-six samples (51.6%) were positive for HPV detection, and sixty-three (65.6%) of them showed the presence of at least one HR-HPV. Low-and high-grade SIL showed significant association in patients younger than 35 years of age. We found 18 different genotypes, with a greater presence of HR-HPV. Genotypes 16 and 6 were the most frequent. Seven (7.3%) multiple infections, 85.7% of which had at least one HR-HPV, were detected. The detection of a large number of different HPV genotypes is a warning sign. It is thus necessary to strengthen the monitoring of the circulation of high-risk genotypes, currently less prevalent in intraepithelial lesions, as a control measure for the possible impact of the implementation of vaccines against genotypes 16 and 18.

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Section: Discussionsupporting

confidence: 58%

Circulation of human papillomavirus (HPV) genotypes in women from Córdoba, Argentina, with squamous intraepithelial lesions

Venezuela

Kiguen

Frutos

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…( (21) were also found in a substantial proportion of women with CC in Ethiopia.Thus, women infected with such genotypes will not be fully protected from getting CC by the current vaccines.This challenge has also been observed in several other sub-Saharan African countries such as Kenya, (38) Sudan, (39) Benin, (40) Equatorial Guinea, (41) Tanzania, (42) Zambia,…”

Section: Hpv Vaccination Challenges In Ethiopiamentioning

confidence: 67%

Human Papillomavirus Related Cervical Cancer and Anticipated Vaccination Challenges in Ethiopia

Gebremariam

2016

IJHS

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Cervical cancer is the leading cause of cancer deaths among women in Ethiopia. This may be due to the high prevalence of high-risk human papillomavirus (HR-HPV) genotypes in the population. So far, few studies have been done that showed the presence of HR-HPV genotypes. The HR-HPV-16, -18, -52, -56, -31 and -58 were the most common genotypes reported in Ethiopia. The introduction of HPV vaccines in Ethiopia is likely to go a long way in reducing cervical cancer deaths. However, there are few challenges to the introduction of the vaccines. The target population for HPV vaccination is at the moment not well-defined. Besides, the current HPV vaccines confer only type-specific (HPV-16 and -18) immunity, leaving a small proportion of Ethiopian women unprotected against other HR-HPV genotypes such as 52, 56, 31 and 58. Thus, future HPV vaccines such as the nanovalent vaccine may be more useful to Ethiopia as they will protect women against more genotypes.

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“…The different subregions were fairly well represented, except for Middle Africa, with only one study from the Democratic Republic of Congo. HPV prevalence ranged between 3.2% in Sudan [10] and 47.9% in Guinea [11]. Although the reason for this is not very clear, this wide distribution could be explained by methodological differences between the studies, resulting in inclusion of study populations that show different risk for the presence of HPV, such as age or sexual behaviour.…”

Section: Cervical Hpv Infection and Type Distribution In Sub-saharmentioning

confidence: 99%

The Burden of Human Papillomavirus Infections and Related Diseases in Sub-Saharan Africa

Vuyst

Alemany

Lacey

et al. 2013

Vaccine

197

228

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Despite the scarcity of high quality cancer registries and lack of reliable mortality data, it is clear that human papillomavirus (HPV)-associated diseases, particularly cervical cancer, are major causes of morbidity and mortality in sub-Saharan Africa (SSA). Cervical cancer incidence rates in SSA are the highest in the world and the disease is the most common cause of cancer death among women in the region. The high incidence of cervical cancer is a consequence of the inability of most countries to either initiate or sustain cervical cancer prevention services. In addition, it appears that the prevalence of HPV in women with normal cytology is higher than in more developed areas of the world, at an average of 24%. There is, however, significant regional variation in SSA, with the highest incidence of HPV infection and cervical cancer found in Eastern and Western Africa. It is expected that, due to aging and growth of the population, but also to lack of access to appropriate prevention services and the concomitant human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemic, cervical cancer incidence and mortality rates in SSA will rise over the next 20 years. HPV16 and 18 are the most common genotypes in cervical cancer in SSA, although other carcinogenic HPV types, such as HPV45 and 35, are also relatively more frequent compared with other world regions. Data on other HPV-related anogenital cancers including those of the vulva, vagina, anus, and penis, are limited. Genital warts are common and associated with HPV types 6 and 11. HIV infection increases incidence and prevalence of all HPV-associated diseases. Sociocultural determinants of HPV-related disease, as well as the impact of forces that result in social destabilization, demand further study. Strategies to reduce the excessive burden of HPV-related diseases in SSA include age-appropriate prophylactic HPV vaccination, cervical cancer prevention services for women of the reproductive ages, and control of HIV/AIDS.

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Genotypes of human papilloma virus in Sudanese women with cervical pathology

Cited by 24 publications

References 17 publications

Circulation of human papillomavirus (HPV) genotypes in women from Córdoba, Argentina, with squamous intraepithelial lesions

Circulation of human papillomavirus (HPV) genotypes in women from Córdoba, Argentina, with squamous intraepithelial lesions

Human Papillomavirus Related Cervical Cancer and Anticipated Vaccination Challenges in Ethiopia

The Burden of Human Papillomavirus Infections and Related Diseases in Sub-Saharan Africa

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