Genotypes of hepatitis B virus identified in patients tested prior to endoscopy from a Teaching Hospital in the Central Province of Sri Lanka

Jayasuriya, D G D; Noordeen, F.; Pitchai, Fathima Nuzra Nagoor

doi:10.4038/cmj.v60i2.8153

Cited by 2 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The least prevalent among this cohort was genotype A at 8% while C and D occurred at a prevalence of 16 and 12%, respectively. 21 A more recent study carried out by Jayasuriya et al (2015) 22 in Kandy in a small cohort of HBsAg positive individuals showed the presence of genotype A. These studies collectively show the presence of multiple genotypes of HBV in Sri Lanka 21,22 and this might have implications on the epidemiology of HBV infection in the future.…”

Section: Hbv Epidemiology In Sri Lankamentioning

confidence: 94%

A Review of Hepatitis B Virus Infection in Sri Lanka

Noordeen

Pitchai

Rafeek

2015

Sri Lankan J Infec Dis

Self Cite

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection is a major public health concern in many Southeast Asian, South Asian and African countries. HBV infection is transmitted sexually or by other parenteral routes. HBV causes an acute viral hepatitis or chronic infection, largely based on the age at which the infection is acquired. In the majority of infected infants, HBV causes a chronic protracted infection for decades without symptoms. After several decades, the infection might flare up to give rise to an active hepatitis followed by sero-conversion to anti-HBs. However, the vast majority of patients with chronic HBV (CHB) infection will have chronic liver disease. Some with CHB infection develop a primary liver cancer, hepatocellular carcinoma (HCC) later in life. Approximately 25 percent of chronically infected individuals die prematurely of cirrhosis or HCC. The prevalence of HBV infection in Sri Lanka is estimated to be less than 2%. Sri Lanka is therefore considered a country of low endemicity. This prevalence rate of HBV in Sri Lanka is very different to that in many other South Asian countries such as India and Bangladesh. Diagnosis of HBV infection in Sri Lanka is carried out in many private and state laboratories using immunochromatography based rapid assays or ELISAs for HBV surface antigen (HBsAg) detection. Those with latter stages of CHB are treated with currently available nucleotide / nucleoside analogues in some private sector hospitals where testing facilities for virus load during different stages of treatment is available. Sri Lanka has a policy of immunizing healthcare workers (HCW) who are at risk of acquiring HBV occupationally. Sri Lanka included HBV immunization in the Expanded Program of Immunization (EPI) with effect from 2003. In all HBsAg immunization programmes for HCW, testing for the protective anti-HBs response is mandatory in those who receive a complete course of immunization in order to ensure immunity in responders and to re-vaccinate non-responders.

show abstract

Section: Hbv Epidemiology In Sri Lankamentioning

confidence: 94%

A Review of Hepatitis B Virus Infection in Sri Lanka

Noordeen

Pitchai

Rafeek

2015

Sri Lankan J Infec Dis

Self Cite

View full text Add to dashboard Cite

show abstract

“…The HBV genome is described as a partially double stranded circular DNA molecule, 3200 base pairs long (Guettouche & Hnatyszyn, 2005;Jayasuriya, Noordeen, & Pitchai, 2015). Sequencing and phylogenetic investigations of the genome demonstrate the presence of eight distinct genotypes (A-H) and various sub-types of HBV (Guirgis, Abbas, & Azzazy, 2010).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic strategy for occult hepatitis B virus infection and its clinical implications among patients at Upper Egypt

El-Adly

Meshaal

Mekky

et al. 2020

Journal of Radiation Research and Applied Sciences

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection is an important health problem and the major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) especially in Upper Egypt. The aim of this study was to estimate the prevalence of HBV among Assiut governorate patients. Our study examined 1085 patients for HBsAg at Assiut governorate, Egypt. Out of the 1085 population tested for HBsAg, 623 (57.5%) were males whereas 462 (42.5%) were females. A total of 165 out 1085 were seropositive for HBsAg (15.2%). The highest seropositive of HBsAg were recorded in 106/623 males (17.1%) compared as 59/462 females (12.8%). HBsAg seropositive were decreased with grassing age, the highest seroprevalence of HBsAg 62/165 (37.6%) was recorded in age ranges between 21 and 30 years, while the lowest seroprevalence of HBsAg 8/165 (4.8%) was recorded in age >60 year. All patients were divided into four groups according to HBV-DNA. Seroprevalence of HBsAg was increased with group 2 (Low titer of HBV-DNA <2000 IU/mL) (46.1%), where highest prevalence of HBsAg was recorded in males (37.6%) compared to as females (8.5%). The lowest seroprevalence of HBsAg were recoded with group 3 (high titer of HBV-DNA > 2000 IU/mL) (14.5%). HBV was common in rural versus urban community areas (78.2% versus 21.8%, respectively). Screening of HBV infection to monitor liver disease progression in HBV carriers by using molecular, biochemical, and serological markers, so that effective treatment can be initiated early before the development of advanced liver disease.

show abstract

Genotypes of hepatitis B virus identified in patients tested prior to endoscopy from a Teaching Hospital in the Central Province of Sri Lanka

Cited by 2 publications

References 6 publications

A Review of Hepatitis B Virus Infection in Sri Lanka

A Review of Hepatitis B Virus Infection in Sri Lanka

Diagnostic strategy for occult hepatitis B virus infection and its clinical implications among patients at Upper Egypt

Contact Info

Product

Resources

About