Genotype-specific prevalence of human papillomavirus infection in asymptomatic Peruvian women: a community-based study

Abstract

Objective To determine the general and genotype-specific prevalence of HPV and to identify potential risk factors for the infection in a population-based screening of Peruvian women. Results A total of 524 samples were analyzed by PCR and a total of 100 HPV positive samples were found, of which 89 were high-risk, 19 were probably oncogenic, 9 were low-risk and 27 other HPV types. The 26–35 and 36–45 age groups showed the highest proportion of HPV positive samples with a total of 37% (37/100) and 30% (30/100), respectively. Moreover, high-risk HPV was found in 33.7% of both groups and probably oncogenic HPV in 52.6% and 31.6%, respectively. High-risk HPV were the most frequent types identified in the population studied, being HPV-52, HPV-31 and HPV-16 the most commonly detected with 17.6%, 15.7% y 12.9%, respectively. Demographic characteristics and habits were assessed in the studied population. A total of 62% high-risk HPV were detected in married/cohabiting women. Women with two children showed the highest proportion (33.8%) of high-risk HPV, followed by women with only one child (26.9%). Those women without history of abortion had a higher frequency of high-risk HPV (71.9%), followed by those with one abortion (25.8%).

Prevalence of coinfections in a cross-sectional cohort of women screened for multiple pathogens in Peru

“…For example, in 2018 Ponce‐Benavente et al found that 30.48% samples were positive for HPV, of which 63.6% were high-risk genotypes, 23.1% were of probable oncogenic risk, and 7.4% were low risk [ 27 ]. Another study carried out in Cajamarca also found that the most frequent genotypes were high risk, with HPV-52, HPV-31 and HPV-16 being the most prevalent [ 28 ]. Likewise, a study from Brazil found a prevalence of 33.8% of HPV, where 59.1% were high risk, 16.9% probable oncogenic risk and 24% low risk [ 29 ].…”

Retrospective Analysis of The 3-Year Outcomes of High-Risk HPV Frequency and Genotype Distribution in Female Patients Admitted to A University Hospital

“…Genital HPV genotipleri kanser yapma potansiyellerine göre yüksek risk (HR) ve düşük risk (LR) gruplarına ayrılmaktadır (2) . HPV enfeksiyonları dünya çapında en yaygın cinsel yolla bulaşan enfeksiyonlardandır (STI) ve her iki cinsiyet içinde, cinsel olarak aktif bireylerin en az %50'sini hayatlarının bir noktasında etkiler (3) . GLOBOCAN'ın 2018 istatistiklerine göre, servikal kanserler kadınlarda en sık saptanan kanserler arasında dördüncü sırada görülmektedir.…”

Review Article: Immune Landscape and Immunotherapy Options in Cervical Carcinoma

“…From these genera, types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68 have been identified as high risk and types 6, 11, 42, and 44 have been identified as low-risk HPV types. In 90% of cervical cancer cases, HPV types 16 and 18 are found to be involved [ 2 ]. In a study conducted worldwide, the prevalence rate of HPV genotypes associated with cervical cancer were HPV16 (61%), HPV18 (10%), HPV31 (4%), and HPV33.…”