Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke

Effects of NAD(P)H quinone oxidoreductase 1 polymorphisms on stable warfarin doses in Korean patients with mechanical cardiac valves

“…The results from rs1800566 polymorphism are supported by previous in vitro and in vivo data that variants have loss of enzyme activity and decreased levels of clotting factors [13,15]. Our study results demonstrate that patients with variant homozygotes required 15.7 % reduced dose and those with heterozygotes required 4.9 % reduced dose, as compared to those with wild-type homozygotes.…”

“…However, their result was opposite to our findings; warfarin doses were higher in patients with variant alleles. Referring to this discrepancy authors of the study admitted, their results were also contrary to the finding from other in vivo studies [14,15]. Previous in vitro and in vivo data showed that variants in rs1800566 had loss of enzyme activity and decreased levels of clotting factors.…”

“…In the clinical setting, a previous study in Taiwanese populations showed that carriers of the C609T polymorphism of NQO1 had lower levels of blood coagulation factors than those with wild type [15]. The frequency of NOQ1 polymorphism (rs1800566) exhibited ethnic variation, with the highest minor allele frequency occurring in Asian populations [16].…”

ANALYSIS OF γ-GLUTAMYL CARBOXYLASE GENE rs2592551 POLYMORPHISM ASSOCIATION WITH ISCHEMIC ATHEROTHROMBOTIC STROKE

“…Доcлідники виявили про-тективний ефект зазначених поліморфізмів відносно ризику розвитку ішемічного ін-сульту. Синергізм досліджуваних локусів був більш вираженим у пацієнтів, які не були курцями та не вживали спиртних напоїв [27]. Подібний протективний ефект щодо розвитку ішемічного інсульту також був знайдений нами в представленому дослідженні у жінок з гетерозиготним генотипом за поліморфним локусом 9-го екзона гена GGCX.…”

VKORC1 rs2359612 and rs9923231 polymorphisms correlate with high risks of cardiovascular and cerebrovascular diseases

“…Finally, 10 clinical case-control studies (Watzka et al, 2007;Arnold et al, 2008;Lemmens et al, 2008;Shyu et al, 2010;Zhang and Zhang, 2012;Li, 2013;Ragia et al, 2013;Wang et al, 2006Wang et al, , 2013Niu and Wei, 2014), published from 2006 to 2014 and representing 7329 patients with CCVD and 7951 healthy controls, were selected for this meta-analysis. Genotype distribution in the metaanalysis was consistent with Hardy-Weinberg equilibrium (HWE) (all P > 0.05).…”