Genotype-phenotype correlations in hepatocellular adenoma: an update of MRI findings

Thomeer, Marteen G.; Bröker, Mirelle; Lussanet, Quido de; Biermann, Katharina; Dwarkasing, Roy S.

doi:10.5152/dir.2013.13315

Cited by 21 publications

(20 citation statements)

References 39 publications

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“…Independently from the subtype, we noted that approximatively 70% of HCA did not display OATPB1/B3 expression. Thus, our results suggest that the “no HBP uptake” criterion proposed in several radiological papers is indeed generally helpful to separate FNH from the majority of HCA . These observations are in accordance with those reported in a systematic review, showing that FNH have iso‐ or high signal, while most HCA has low signal on HBP as compared to the background liver .…”

Section: Discussionsupporting

confidence: 90%

OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd‐EOB‐DTPA uptake and correlates with risk of malignancy

Sciarra

Schmidt

Pellegrinelli

et al. 2018

Liver International

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Section: Discussionsupporting

confidence: 90%

OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd‐EOB‐DTPA uptake and correlates with risk of malignancy

Sciarra

Schmidt

Pellegrinelli

et al. 2018

Liver International

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“…The present study showed that a pooled proportion of fatty degeneration in HCA of 37% (95% CI: 0.27-0.49).The MRI sign is only found in the H-HCA pathological subtype 10. Grazioli L and Purysko AS et al 5-6 reported that fatty tissues are also found in FNH, and could not actually differentiate HCA from FNH just according to the presence of fatty tissues in the tumor 18-19.…”

Section: Discussioncontrasting

confidence: 56%

Diagnostic Value of Gd-EOB-DTPA-MRI for Hepatocellular Adenoma: A Meta-Analysis

Guo

Xie

et al. 2017

J. Cancer

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Objective: This study aimed to systematically review the gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) findings of hepatocellular adenoma (HCA), especially focusing on the diagnostic value of low signal intensity (SI) in the hepatocyte-phase (HBP) for differentiating HCA from focal nodular hyperplasia (FNH).Methods: A thorough literature search was conducted in PubMed, Excerpta Medica Database (EMBASE) and China National Knowledge Infrastructure databases (CNKI) to identify studies evaluating Gd-EOB-DTPA-MRI presentations of HCA. Published studies using pathological examinations as the gold standard were included. The pooled proportions of low SI in the HBP, arterial-phase, portal venous-phase (PVP) in HCA were calculated, as well as pooled proportions of bleeding, fatty degeneration, and central scar. Meta-analysis was used to evaluate the diagnostic value of low SI in the HBP for HCA.Results: The search yielded 90 studies, with 8 assessing a total of 256 HCA cases included in this study, total of 229 lesions showed low signal in the HBP. Pooled proportions of low SI in the arterial-phase, PVP, and HBP were 2% (95% CI: 0.01-0.05), 39% (95% CI: 0.25-0.55), and 89% (95% CI: 0.80-0.94), respectively. Pooled proportions of bleeding, fatty degeneration, and central scar in HCA were 11% (95% CI: 0.03-0.19), 37% (95% CI: 0.27-0.49), and 10% (95% CI: 0.03-0.27), respectively. The meta-analysis revealed the following characteristics of low SI in the HBP for HCA diagnosis: 1) pooled sensitivity, 0.917 (95% CI: 0.86-0.96); 2) pooled specificity, 0.952 (95% CI: 0.91-0.98); 3) pooled positive likelihood ratio, 15.028 (95% CI: 7.10-31.82); 4) pooled negative likelihood ratio, 0.105 (95% CI: 0.07-0.17); 5) area under the ROC, 0.9802 (Q value of 0.9375), The sensitivity analysis showed that no single study was found to influence the overall pooled estimates significantly, which indicated the stability of the meta-analysis results were good.Conclusions: Low SI on the HBP of Gd-EOB-DTPA-MRI was helpful for the diagnosis of HCA and differentiating from FNH, but it was overvalued, especially for some HCA pathological subtypes. Combining low SI in the HBP with routine MRI presentations and the risk factors of liver diseases could substantially improve its diagnosis value for HCA as well as differential diagnosis.

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“…MRI should be preferred in such cases and presence of scar on T2-weighted images and hyperintensity on hepatobiliary phase T1-weighted images after injection of hepatocyte specific agents can be helpful in making the diagnosis (Fig. 8b, 8c) (16,17). Metastasis can mimic focal fat and fat sparing.…”

Section: Mimickersmentioning

confidence: 99%

Imaging of aberrant left gastric vein and associated pseudolesions of segments II and III of the liver and mimickers

Ünal¹,

Ozmen²,

Akata³

et al. 2015

Diagn Interv Radiol

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We present imaging findings of aberrant left gastric vein (ALGV) and associated pseudolesions and mimickers including metastases and focal nodular hyperplasia. ALGV is formed due to interrupted involution of anastomotic omental veins, and it can drain into left portal vein or segments II and III of the liver as third inflow. Focal fat, focal fat sparing, and perfusion changes can be seen due to the presence of ALGV, which can mimic metastasis in cancer patients. ALGV may also serve as a pathway for direct tumor spread into the liver in patients with gastric cancer. Magnetic resonance imaging can be used as a problem solving tool in the presence of equivocal findings on ultrasonography and computed tomography. Pseudolesions of the liver are a well-known issue and have been reported in the literature. These pseudolesions are caused by aberrant hepatopedal venous flow other than portal venous system, also known as third inflow. Third inflow is most commonly due to aberrant right gastric, paraumbilical, and cholecystic veins (1-3). Pseudolesions caused by aberrant left gastric vein (ALGV) are considered to be a more rare entity (4).The purpose of this study is to illustrate ALGV drainage into the liver and associated pseudolesions of segments II and III of the liver. In addition, we illustrate imaging findings of the mimickers of these pseudolesions. Embryology and anatomyThe left gastric vein receives branches of the inferior paraesophageal region and minor curvature of the stomach. Thereafter, it runs along the hepatogastric ligament and merges with the left aspect of the portal vein or confluence of the portal and splenic veins. The right gastric vein also receives blood from minor curvature of the stomach and merges with the right aspect of the portal vein.Aberrant left and right gastric veins develop due to morphogenetic changes during the developmental process in the early embryonic life (5). The main cause is interrupted involution of the anastomotic omental veins, so that typical left gastric vein does not form. Anastomotic omental veins are the anastomoses between primitive foregut venous plexus and ductus venosus, which normally exist during early embryonic life (5, 6).

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Genotype-phenotype correlations in hepatocellular adenoma: an update of MRI findings

Cited by 21 publications

References 39 publications

OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd‐EOB‐DTPA uptake and correlates with risk of malignancy

OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd‐EOB‐DTPA uptake and correlates with risk of malignancy

Diagnostic Value of Gd-EOB-DTPA-MRI for Hepatocellular Adenoma: A Meta-Analysis

Imaging of aberrant left gastric vein and associated pseudolesions of segments II and III of the liver and mimickers

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