Genotype of the CYBA promoter −930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: An observational study

Stiefel, Pablo; Miranda, María Luisa; Bellido, Lola M.; Luna, Jerónimo; Jiménez, Luís; Pamies, E.; Frutos, Pablo García de; Villar, José R.

doi:10.1016/j.medcli.2009.03.042

Cited by 27 publications

(16 citation statements)

References 29 publications

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“…Most recently, the meta-analysis by Xia et al (95) reported that the TT genotype compared with the CC and CT genotypes carried a significantly greater risk of preeclampsia (by 76%) among Asian women only, whereas in Caucasian women this increased risk was not evident. It is worth noting however that a much greater number of large-scale studies in this area have been conducted within Asian populations with far fewer studies conducted in Caucasian populations; a factor that limits Sohda et al (87) 425 Japan 2·5 (1·3, 4·8) Grandone et al (88) 225 Italy 1·8 (1·0, 3·5) Kupferminc (96) 144 Israel 2·9 (1·0, 8·5) Powers et al (97) 237 Caucasian women 1·28 (0·58, 2·79) Kobashi et al (98) 316 Japan 0·68 (0·30, 1·55) Laivuori et al (99) 216 Finland 0·50 (0·14, 1·77) Rigo et al (100) 221 Caucasian women 1·13 (0·38, 3·37) Morrison et al (101) 404 Scotland 1·00 (0·55, 1·82) Prasmusinto et al (102) 112 Germany and Croatia 0·28 (0·03, 2·47) Pegoraro et al (103) 609 South African (Black) 0·62 (0·06, 6·90) Perez-Mutul et al (91) 325 Mexico 0·94 (0·59, 1·49) Williams et al (104) 304 Peru 1·6 (0·7, 3·8) Yilmaz et al (105) 111 Turkey 0·84 (0·26, 2·67) Also-Rallo et al (79) 165 Spain 0·73 (0·31, 1·76) Hernandez-Diaz et al (86) 154 USA/Canada 3·0 (1·2, 7·7) Stiefel et al (106) 584 Spain 0·92 (0·50, 1·71) the extent to which different populations can be compared. An additional limitation is that genotype-driven recruitment is generally not undertaken in these studies, a feature that is reflected by the relatively small numbers of pregnant women with the TT genotype being investigated and these raised the concern that many such studies may be statistically underpowered.…”

Section: Role Of the Mthfr Genotype In Determining The Risk Of Hypertmentioning

confidence: 99%

MTHFR677TT genotype and disease risk: is there a modulating role for B-vitamins?

et al. 2013

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Methylenetetrahydrofolate reductase (MTHFR) is a critical folate-metabolising enzyme which requires riboflavin as its co-factor. A common polymorphism (677C→T) in the MTHFR gene results in reduced MTHFR activity in vivo which in turn leads to impaired folate metabolism and elevated homocysteine concentrations. Homozygosity for this polymorphism (TT genotype) is associated with an increased risk of a number of conditions including heart disease and stroke, but there is considerable variability in the extent of excess risk in various reports. The present review will explore the evidence which supports a role for this polymorphism as a risk factor for a number of adverse health outcomes, and the potential modulating roles for B-vitamins in alleviating disease risk. The evidence is convincing in the case which links this polymorphism with hypertension and hypertensive disorders of pregnancy, particularly preeclampsia. Furthermore, elevated blood pressure was found to be highly responsive to riboflavin intervention specifically in individuals with the MTHFR 677TT genotype. Future intervention studies targeted at these genetically predisposed individuals are required to further investigate this novel gene–nutrient interaction. This polymorphism has also been associated with an increased risk of neural tube defects (NTD) and other adverse pregnancy outcomes; however, the evidence in this area has been inconsistent. Preliminary evidence has suggested that there may be a much greater need for women with the MTHFR 677TT genotype to adhere to the specific recommendation of commencing folic acid prior to conception for the prevention of NTD, but this requires further investigation.

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Section: Role Of the Mthfr Genotype In Determining The Risk Of Hypertmentioning

confidence: 99%

MTHFR677TT genotype and disease risk: is there a modulating role for B-vitamins?

et al. 2013

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“…While in some populations including white women from Italy [5] and Japanese women [6,7] a significant association between maternal MTHFR C677T with severe preeclampsia through elevation of homocystein concentration has been suggested. Other studies from populations of United States [8], Spain [9], United Kingdom [11] and Brazil [10] failed to indicate an association between this polymorphism and the risk of preeclampsia or even a protective role for this polymorphism against preeclampsia among Mexican Maya-Mestizo population [12] has been suggested. In our population higher frequency of combined genotypes of MTHFR CT and TT in preeclamptic women compared to the same genotype in controls was not associated with the risk of severe preeclampsia.…”

Section: Discussionmentioning

confidence: 97%

“…There are several reports of association between MTHFR C677T polymorphism and the risk of preeclampsia in different populations with some inconsistencies [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

MTHFR C677T and eNOS G894T variants in preeclamptic women: Contribution to lipid peroxidation and oxidative stress

Rahimi

Malek-Khosravi

Rahimi

et al. 2013

Clinical Biochemistry

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“…The conclusions for those comparisons were robust to some extent. Stiefel et al 38 reported that apoE E3E4 and E4E4 genotypes had a worse lipoprotein profile characterized by higher plasma value of TG. Srivastava et al 39 found that higher TG level was observed in obese subjects with apoE e4 allele than individuals without apoE e4.…”

Section: Discussionmentioning

confidence: 99%

Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases

et al. 2013

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Apolipoprotein E (apoE), one of the major plasma lipoproteins, plays a major role in the transport and metabolism of lipids by acting as a ligand. apoE gene contains three potential alleles: e2, e3 and e4, forming six genotypes: E2E2, E2E3, E2E4, E3E3, E3E3 and E4E4. Association between apoE gene polymorphism and triglyceride (TG) is still controversial. There was no any meta-analysis to explore the association of apoE gene polymorphism with triglyceride level, and this meta-analysis was performed to evaluate the association between apoE gene polymorphism and triglyceride in patients with renal diseases. A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases. Twenty-four articles were identified for the analysis of association between apoE gene polymorphism and triglyceride level. Subjects with E2E3 or E3E4 had a higher TG than those with E3E3. Subjects with e4 had a higher TG than those with e3. Subjects with e2 had a slightly higher TG than those with e3, although there was no statistical difference. Interestingly, subjects with e4 had a much higher TG than those with e2. In conclusion, E2E3, E3E4 or e4 was associated with higher level of TG. However, more studies should be performed in the future.

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Genotype of the CYBA promoter −930A/G, polymorphism C677T of the MTHFR and APOE genotype in patients with hypertensive disorders of pregnancy: An observational study

Cited by 27 publications

References 29 publications

MTHFR677TT genotype and disease risk: is there a modulating role for B-vitamins?

MTHFR677TT genotype and disease risk: is there a modulating role for B-vitamins?

MTHFR C677T and eNOS G894T variants in preeclamptic women: Contribution to lipid peroxidation and oxidative stress

Relationship between apolipoprotein E gene polymorphism with triglyceride level in patients with renal diseases

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