Genotype‐Guided Model for Prediction of Tacrolimus Initial Dosing After Lung Transplantation
Wenwen Du,
Xiaoxing Wang,
Dan Zhang
et al.
Abstract:The determination of the appropriate initial dose for tacrolimus is crucial in achieving the target concentration promptly and avoiding adverse effects and poor prognosis. However, the trial‐and‐error approach is still common practice. This study aimed to establish a prediction model for an initial dosing algorithm of tacrolimus in patients receiving a lung transplant. A total of 210 lung transplant recipients were enrolled, and 26 single nucleotide polymorphisms (SNP) from 18 genes that could potentially affe… Show more
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