Genotype Frequencies of 50 Polymorphisms for 241 Japanese Non-cancer Patients.

Abstract

This paper lists the genotype frequencies of 50 polymorphisms of 37 genes (ALDH2, ADRB2, ADRB3, COMT, CD36, CXCR2, CCND1, COX2, CYP2A6, CYP17, CYP19, IGF1, IL-1A, IL-1B, IL-1RN, IL-1R1, IL-6, IL-8, IL-10, LEP, Le, L-myc, MPO, MTR, MTHFR, MAO-A, NQO1, OGG1, p53, p73, Se, SRD5A2, TGF-B, TNF-A, TNF-B, XPD, and XRCC1) and 6 sets of combined genotype frequencies for 241 non-cancer Japanese outpatients. Though the genotype frequencies of 25 polymorphisms have already been reported in our previous papers, 15 polymorphisms (CD36 A52C, CXCR2 C785T, CCND1 G870A, IGF1 C/T at intron 2 and G2502T, IL-1A 46-bp VNTR, IL-1R1 C-116T, IL-6 Ins/Del 17C, IL-8 A-278T and C74T, IL- 10 T-819C, LEP A-2548G, SRD5A2 2-bp VNTR, XPD Lys751Gln, and XRCC1 Arg399Gln) and six sets of combined genotype frequencies (IL-1B C-31T and IL-1A C-889T, IL-1B C-31T and IL-1RN 86-bp VNTR, IL-1B C-31T and IL-1R1 C-116T, TNF-A G-308A and TNF-B A252G, SRD5A2 Val89Leu and 2-bp VNTR, and XRCC1 Arg399Gln and XPD Lys751Gln) were reported in this paper for the first time for Japanese. Although microarray technology will produce this kind of information in near future, this is the first document that reports the genotype/allele frequencies among Japanese for an archival purpose.

Association of leptin genetic polymorphism -2548 G/A with gestational diabetes mellitus

“…These findings proved to be consistent with allele frequencies reported recently for the German and French population (Mammes et al, 2000, Nieters et al, 2002. The A allele in the Japanese population showed essentially higher frequency (60.8%, Hamajima et al, 2002) than in the Czech Republic, which confirms previous findings.…”

DNA repair gene XRCC1 and XPD polymorphisms and the risk of idiopathic azoospermia in a Chinese population

“…On the basis of analyzing 171 idiopathic azoospermia patients and 247 frequency-matched controls in a Chinese population, we found that the XPD 751 Gln/Gln genotype was rarely observed in the controls, which was in agreement with previous reports that the Gln/Gln genotype was uncommon in China (18), South Korea (19), and Japan (20). However, the Gln allele was common in Europe and North America; approximately 50% carried the heterozygous Lys/Gln genotype and 10-15% had the homozygous Gln/Gln genotype (21).…”

Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes

“…The first group included 241 outpatients with no history of cancer who participated in an H. pylori eradication program (HPE group) at Aichi Cancer Center Hospital in 1999 [4], and whose genotype background was reported for 50 polymorphisms [21]. The group included 97 patients who were stated to be receiving medication (a total of 107 diseases; for gastric/duodenal ulcer, in 23; so-called gastritis, in 23; hypertension, in 16; and for other 123 miscellaneous diseases).…”