Genotype f prevails in Venezuelan urban patients with chronic hepatitis B

Machado, Irma; Fortes, María del Pilar; Vargas-Lovelle, Berta; Trómpiz, Aleidy; López, D; León, Roberto; Senior, Marilyn B.; Dagher, Lucy; López, Carmen Esther; Pestana, Elena; Bacalao, Román; Garassini, M

doi:10.1016/s1665-2681(19)31657-6

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…Moreover, Venezuela is classified with an intermediate prevalence of hepatitis B surface antigen (HBsAg) in urban areas, while the Venezuelan Aboriginal population has a high prevalence of HBsAg [48,49]. HBV genotype F has been well-documented as the most prevalent [49,50].…”

Section: Hbv Genotypes In Latin Americamentioning

confidence: 99%

Distribution of HBV Genotypes in Latin America

Alvarado-Mora

Pinho

2005

Antiviral Therapy

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Approximately 2 billion people worldwide are infected with HBV, and 350 million people are chronic carriers. HBV is classified into nine genotypes (A to I). Genotype F is the most prevalent in the Spanish-speaking countries and in the Amerindian population in South America. HBV genotype F was primarily found in indigenous populations from South America and is divided into four subgenotypes (F1 to F4). Subgenotype F1 is further divided into F1a (found in Costa Rica and El Salvador) and F1b (found in in Alaska, Argentina and Chile). Subgenotypes F2 and F3 cocirculate in the north of South America: F2a is found in Brazil and Venezuela, F2b is described only in Venezuela, F3 is frequent in Colombia, Venezuela and Panama, and F4 is reported from the central and south areas of South America, including Bolivia, Argentina and southern Brazil. HBV genotypes and subgenotypes have distinct geographical distributions. It is currently under discussion whether they are associated with different prognoses, considering the patterns of severity of liver diseases in various populations. Furthermore, global human migrations affect the pattern of genotype distribution, introducing genotypes differing from those found in the original inhabitants.

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Section: Hbv Genotypes In Latin Americamentioning

confidence: 99%

Distribution of HBV Genotypes in Latin America

Alvarado-Mora

Pinho

2005

Antiviral Therapy

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“…Furthermore, we have previously reported that approximately 12% of our chronic hepatitis B population is HBe-antigen negative. This implies that they are harbouring precore/core HBV variants such as our patient [3,4].…”

Section: Discussionmentioning

confidence: 96%

Autoimmune Manifestations in Chronic Hepatitis B

Machado¹

2017

GHOA

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The chronic hepatitis B infection (CHB) has been associated to a variety of autoimmune manifestations, including circulating non-organ-specific autoantibodies, membranous proliferative glomerulonephritis, mixed cryoglobulinaemia and polyarteritis nodosa. The diagnosis and treatment depend on the affected organs and demonstration of viral activity. However, we should initially assess the probable clinical diagnosis in which its outcome and long-term resolution depend on the proper use of antiviral drugs. Herein, we reported an unusual clinical presentation of hepatitis B reactivation in an antigen e-negative CHB patient.

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“…Several studies have associated subgenotype F1b infection, particularly in Alaska and Peru, with an early and rapid progression of liver disease, and evolution to HCC ( Livingston et al, 2007 ; Machado et al, 2010 ; Mizushima et al, 2010 ; Pineau et al, 2018 ; Pujol et al, 2020 ; McMahon et al, 2021 ). However, despite the high prevalence of subgenotype F1b in Argentina ( Ledesma et al, 2015 ; Rodrigo et al, 2016 ), HBV infection is not frequently related with the development of HCC ( Fassio et al, 2009 ; Piñero et al, 2018 ), and an association of subgenotype F1b infection with a more severe progression of liver disease has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Molecular and biological characterization of hepatitis B virus subgenotype F1b clusters: Unraveling its role in hepatocarcinogenesis

et al. 2022

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Hepatitis B virus (HBV) subgenotype F1b infection has been associated with the early occurrence of hepatocellular carcinoma in chronically infected patients from Alaska and Peru. In Argentina, however, despite the high prevalence of subgenotype F1b infection, this relationship has not been described. To unravel the observed differences in the progression of the infection, an in-depth molecular and biological characterization of the subgenotype F1b was performed. Phylogenetic analysis of subgenotype F1b full-length genomes revealed the existence of two highly supported clusters. One of the clusters, designated as gtF1b Basal included sequences mostly from Alaska, Peru and Chile, while the other, called gtF1b Cosmopolitan, contained samples mainly from Argentina and Chile. The clusters were characterized by a differential signature pattern of eight nucleotides distributed throughout the genome. In vitro characterization of representative clones from each cluster revealed major differences in viral RNA levels, virion secretion, antigen expression levels, as well as in the localization of the antigens. Interestingly, a differential regulation in the expression of genes associated with tumorigenesis was also identified. In conclusion, this study provides new insights into the molecular and biological characteristics of the subgenotype F1b clusters and contributes to unravel the different clinical outcomes of subgenotype F1b chronic infections.

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Genotype f prevails in Venezuelan urban patients with chronic hepatitis B

Cited by 5 publications

References 21 publications

Distribution of HBV Genotypes in Latin America

Distribution of HBV Genotypes in Latin America

Autoimmune Manifestations in Chronic Hepatitis B

Molecular and biological characterization of hepatitis B virus subgenotype F1b clusters: Unraveling its role in hepatocarcinogenesis

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