Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients

Abstract

Abstrak Metode: Penelitian dilakukan dengan teknik PCR-RFLP menggunakan enzim restriksi Bgl II pada gen TCR-β. Analisis PCR-RFLP gen TCR-β digunakan untuk mendeterminasi alotip gen TCR-β pada penderita KNF dan kontrol dan pada kelompok etnis Cina dan pribumi dalam populasi Indonesia. Hasil: Hasil penelitian menunjukkan bahwa distribusi alotip gen TCR-β pada penderita KNF dan kontrol tidak berbeda bermakna (p > 0,05). Frekuensi alel A meningkat pada penderita KNF. Distribusi alotip gen TCR-β antara etnis Cina dan kelompok pribumi tidak memperlihatkan perbedaan bermakna (p> 0,05). Kesimpulan: Distribusi alel gen TCR-β antara kelompok KNF dengan kelompok kontrol tidak menunjukkan perbedaan. Distribusi alel gen TCR-β antara etnis Cina dan pribumi tidak menunjukkan perbedaan. Polimorfi sme gen TCR-β tidak berhubungan dengan KNF dan etnis pada populasi Indonesia. (Med J Indones 2011; 20:171-7) AbstractBackground: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-β gene contribute to the incidence of NPC. This study investigates the association of TCR-β gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups.

Effect of Seahorse (Hippocampus comes L.) Extract on Population and Apoptotic of Spermatogenic and Leydig Cells in Rats After Depot Medroxyprogesterone Acetate Induction

“…Other research has reported that DMPA doses of 1.25 mg/kg body weight could influence gonadotropin and testosterone secretion. 13 The reduction in testosterone that occurs in hypogonadism could activate the mechanism of apoptosis within spermatogenic cells. Research reported that DMPA-treated rats could affect increased apoptosis of spermatogonia (20%), spermatocytes (30%), and 50% of spermatids.…”