Genotype-dependent characteristics of behavior in mice in cognitive tests. The effects of Noopept

Belnik, A. P.; Ostrovskaya, R. U.; Полетаева, И. И.

doi:10.1007/s11055-008-9095-1

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…These differences manifest themselves in cognitive performances where strain-dependent differences have been observed in various spatial memory and contextual conditioning tasks. Specifically, DBA mice are outperformed by BL6 mice in Barnes maze [ 98 ], Morris water maze [ 99 ] and contextual fear conditioning [ 63 ]. Together, our data suggest that chronic exposure to stress could lead to impairments in HC-dependent social and cognitive behavior, comparable to what is seen in various stress-related psychopathologies [ 78 , 90 , 100 , 101 ].…”

Section: Discussionmentioning

confidence: 99%

Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains

et al. 2017

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Alterations in the social and cognitive domain are considered important indicators for increased disability in many stress-related disorders. Similar impairments have been observed in rodents chronically exposed to stress, mimicking potential endophenotypes of stress-related psychopathologies such as major depression disorder (MDD), anxiety, conduct disorder, and posttraumatic stress disorder (PTSD). Data from numerous studies suggest that deficient plasticity mechanisms in hippocampus (HC) and prefrontal cortex (PFC) might underlie these social and cognitive deficits. Specifically, stress-induced deficiencies in neural plasticity have been associated with a hypodopaminergic state and reduced neural plasticity persistence. Here we assessed the effects of unpredictable chronic mild stress (UCMS) on exploratory, social and cognitive behavior of females of two inbred mouse strains (C57BL/6J and DBA/2J) that differ in their dopaminergic profile. Exposure to chronic stress resulted in impaired circadian rhythmicity, sociability and social cognition in both inbred strains, but differentially affected activity patterns and contextual discrimination performance. These stress-induced behavioral impairments were accompanied by reduced expression levels of brain derived neurotrophic factor (BDNF) in the prefrontal cortex. The strain-specific cognitive impairment was coexistent with enhanced plasma corticosterone levels and reduced expression of genes related to dopamine signaling in hippocampus. These results underline the importance of assessing different strains with multiple test batteries to elucidate the neural and genetic basis of social and cognitive impairments related to chronic stress.

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Section: Discussionmentioning

confidence: 99%

Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains

et al. 2017

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“…It should be noted that administration of Noopept 24 h after learning has the same effect [5]. In the water maze task (another type of hippocampus-dependent behavior), administration of Noopept before learning improved memory retrieval under conditions of spatial memory deficit due to cholinergic receptor blockade [2]. This effect was observed in the early and delayed period (24 h and 10 days after learning, respectively).…”

Section: Resultsmentioning

confidence: 99%

Noopept stimulates the expression of NGF and BDNF in rat hippocampus

et al. 2008

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We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus. Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis. Taking into account the fact that pharmacological activity of Noopept is realized after both acute and chronic treatment, we studied the effect of single and long-term treatment (28 days) with this drug. Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression. In the hippocampus, expression of mRNA for both neurotrophins increased after acute administration of Noopept. Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect. These changes probably play a role in neuronal restoration. We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer's disease, but also at the stage of mild cognitive impairment (pre-disease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer's disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer's disease.

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Finding the right motivation: Genotype-dependent differences in effective reinforcements for spatial learning

Youn¹,

Ellenbroek²,

Eck³

et al. 2012

Behavioural Brain Research

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Genotype-dependent characteristics of behavior in mice in cognitive tests. The effects of Noopept

Cited by 4 publications

References 16 publications

Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains

Unpredictable chronic mild stress differentially impairs social and contextual discrimination learning in two inbred mouse strains

Noopept stimulates the expression of NGF and BDNF in rat hippocampus

Finding the right motivation: Genotype-dependent differences in effective reinforcements for spatial learning

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