Genotype-by-Sex Interaction in the Regulation of High-Density Lipoprotein: The Framingham Heart Study

Mosher, M. J.; Martin, Lisa J.; Cupples, L. Adrienne; Yang, Qiong; Dyer, Thomas D.; Williams, Jeff T.; North, Kari E.

doi:10.1353/hub.2006.0017

Cited by 10 publications

(10 citation statements)

References 68 publications

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“…In this regard, several genes have been shown to exert a gender-specific effect on the susceptibility to MS [24,25]. In addition, in [26], making conceivable a substantial difference between men and women in large population studies. Moreover, the frequency of these polymorphisms is strongly influenced by the ethnicity [20], thus different mechanisms related both to genetic or environmental factors could play a role in the susceptibility to autoimmune diseases in different populations.…”

Section: Discussionmentioning

confidence: 99%

Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis

Galimberti¹,

Scalabrini²,

Fenoglio³

et al. 2008

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 99%

Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis

Galimberti¹,

Scalabrini²,

Fenoglio³

et al. 2008

Journal of the Neurological Sciences

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“…Therefore, the possibility of an interaction between gender and genetic factors has been explored in several studies ( 227,228 ). Recently, a GWA study of 18,245 women from a population-based prospective cohort identifi ed a novel locus for HDL-C at 2q24.3 near the genes COBLL1 and GRB14 ( 154 ).…”

Section: Family Studies In Investigation Of Private Variantsmentioning

confidence: 99%

Genetic causes of high and low serum HDL-cholesterol

Weissglas‐Volkov

Pajukanta

2010

Journal of Lipid Research

174

132

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“…These studies suggest that genetic factors are important in determining CVD. In adult cohorts, however, there is increasing evidence that in addition to genetic risk factors influ-encing lipid and coagulation factor levels, modifiable environmental factors such as smoking, alcohol consumption, diet, or exercise are likely to contribute to the pathogenesis of CVD (Czerwinski et al 2004; Middelberg et al 2002; Mosher et al 2005; Perusse et al 1997). Developing statistical methodology allows investigation of traits whose susceptibility to familial influences impinges on the risk of diseases at interest (Almasy and Blangero 1998).…”

mentioning

confidence: 99%

Genetics of Hemostasis: Differential Effects of Heritability and Household Components Influencing Lipid Concentrations and Clotting Factor Levels in 282 Pediatric Stroke Families

Nowak‐Göttl

Langer

Bergs³

et al. 2008

Environ Health Perspect

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BackgroundThe identification of heritable and environmental factors possibly influencing a condition at risk should be a prerequisite for the search for the proportion of variance attributable for shared environmental effects (c2) modulating the risk of disease. Such epidemiologic approaches in families with a first acute ischemic stroke during early childhood are lacking.ObjectivesOur goal was to estimate the phenotypic variation within lipid concentrations and coagulation factor levels and to estimate the proportions attributable to heritability (h2r) and c2 in pediatric stroke families.MethodsBlood samples were collected from 1,002 individuals from 282 white stroke pedigrees. We estimated h2r and c2 for lipoprotein (a) [Lp(a)], cholesterol, high-density lipoprotein, low-density lipoprotein (LDL), fibrinogen, factor (F) II, FV, FVIIIC, von Willebrand factor (vWF), antithrombin, protein C, protein S, plasminogen, protein Z, total tissue factor pathway inhibitor (TFPI), prothrombin fragment F1.2, and D-dimer, using the variance component method in sequential oligogenetic linkage analysis routines.ResultsWhen incorporating h2r and c2 in one model adjusted for age, blood group, sex, smoking, and hormonal contraceptives, significant h2r estimates were found for Lp(a), LDL, fibrinogen, protein C, and protein Z. In addition to the significant h2r estimates, c2 showed a significant effect on phenotypic variation for fibrinogen, protein C, and protein Z. A significant c2 effect was found for cholesterol, and plasma levels of FII, FV, vWF, antithrombin, protein S, plasminogen, and TFPI, ranging from 9.3% to 33.2%.ConclusionsOur research stresses the importance of research on the genetic variability and lifestyle modifications of risk factors associated with pediatric stroke.

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Genotype-by-Sex Interaction in the Regulation of High-Density Lipoprotein: The Framingham Heart Study

Cited by 10 publications

References 68 publications

Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis

Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis

Genetic causes of high and low serum HDL-cholesterol

Genetics of Hemostasis: Differential Effects of Heritability and Household Components Influencing Lipid Concentrations and Clotting Factor Levels in 282 Pediatric Stroke Families

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