Genotype-by-environment interactions govern fitness changes associated with adaptive mutations in two-component response systems
Brittany R. Sanders,
Jordan E. Miller,
Noor Ahmidouch
et al.
Abstract:Introduction: Two-component response systems (TCRS) are the main mechanism by which prokaryotes acclimate to changing environments. These systems are composed of a membrane bound histidine kinase (HK) that senses external signals and a response regulator (RR) that activates transcription of response genes. Despite their known role in acclimation, little is known about the role TCRS play in environmental adaptation. Several experimental evolution studies have shown the acquisition of mutations in TCRS during ad… Show more
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