Genotype and allele frequencies of polymorphisms in ABCG2, PPARGC1A and OLR1 genes in indigenous cattle breeds in Turkey

Abstract

This study was carried out to determine polymorphisms of four genes in South Anatolian Red (SAR) and East Anatolian Red (EAR) indigenous cattle breeds in Turkey. Single nucleotide polymorphisms (SNPs) monitored in this study are Y581S in ATP binding cassette sub family G member 2 (ABCG2) gene, c.1892T>C and c.3359A>C in peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) gene and g.8232C>A in oxidized low-density lipoprotein receptor 1 (OLR1) gene. The frequency of the ancestral allele A of the ABCG2 gene Y581S polymorphism was found to be very high (SAR: 0.63; EAR: 0.64) in both cattle breeds. The CC genotypes of PPARGC1A gene c.1892T>C (SAR: 0.65; EAR: 0.80) and OLR1 gene g.8232C>A polymorphisms (SAR: 0.82; EAR: 0.86), which are associated with high milk fat percentage, had higher frequencies than those of the other genotypes. In conclusion, we might suggest that the allele distribution of the ABCG2 gene Y581S polymorphism can be the evidence indicating autosomal gene flow from zebu cattle to SAR and EAR cattle breeds.

Genome Analysis Reveals Genetic Admixture and Signature of Selection for Productivity and Environmental Traits in Iraqi Cattle

“…Interestingly, genetic studies in Anatolian cattle (Anatolian Black, South Anatolian Red, Anatolian Southern Yellow, and Turkish Grey) have also revealed taurine × zebu admixture (Ateş et al, 2014). Also, Karimi et al (2016) have mentioned that indigenous Iranian cattle from the western part of the country, near the Iraqi border, have more taurine genetic background than southwest Iranian cattle on the south-east border with Iraq, which are more indicine in their genetic background.…”

“…However, the cattle genomes of the Fertile Crescent (including Iraq) have not yet been characterized. The available studies are a microsatellite study (Ates¸ et al, 2014) and mitochondrial DNA analysis for a few breeds (Freeman et al, 2006a, Freeman et al, 2006b; Edwards et al, 2007; Ateş et al, 2014). These studies show evidence of zebu introgression within the Near East taurine, in particular within the Iraqi and Anatolian breeds.…”

Association of Polymorphism of Choosen Genes With Production Traits in Dairy Cattle

“…It has also been proven that PGC1-α is involved in the expression of genes related to oxidative metabolism, adipogenesis and gluconeogenesis (Puigserver and Spiegelman 2003). Ates et al (2014) note that the impact of only two polymorphisms of the PPARGC1A gene on the production characteristics of dairy cattle was confirmed. One of these polymorphisms is c.1892T> C, which results from the substitution of threonine by cysteine in position.…”

Molecular Characterization Of Autochtonus Slavonian Syrmian Podolian Cattle

“…In order to preserve the remaining purebred animals urgent measures are needed, and apart from creating special systems of breeding, it is necessary to solve spatial limitations by moving the animals and, if necessary, to obtain some unrelated high-quality breeding animals from other breeders [2]. In addition, the recent researches [20,21] point at the usefulness of one complement study about effects of certain gene polymorphisms on the improvement of fat deposition and milk yield traits. Any possible following projects on crossbreeding, in order to increase beef and milk production, primarily require breeding of 'purebred' animals and the data collected in this study can undoubtedly contribute to this.…”