Genotoxicity study of photolytically treated 2-chloropyridine aqueous solutions

Vlastos, Dimitris; Skoutelis, Charalambos G.; Theodoridis, Ioannis T.; Stapleton, David R.; Papadaki, Maria

doi:10.1016/j.jhazmat.2009.12.117

Cited by 23 publications

(14 citation statements)

References 33 publications

(60 reference statements)

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“…27,28,[34][35][36] As can be seen in the ESI † ( Fig. In general, the tested mixtures that induce MN may do so because they induce chromosome breakage (clastogenic effect), a chromosome loss (aneugenic effect), or a combination of the two.…”

Section: Significant Enhancement Of the Genotoxic Effect By Mwcnts + Hamentioning

confidence: 99%

Induction of micronuclei by multi-walled carbon nanotubes interacting with humic acids in cultured human lymphocytes

Vidali

Bletsa

Kouloumpis

et al. 2016

Environ. Sci.: Nano

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Mixtures of multi-walled carbon nanotubes (MWCNTs) with natural humic acids (Leonardite humic acid, LHA) or humic acid-like polycondensates (HALP) were evaluated, for the first time, about their potential genotoxic and cytotoxic effects in cultured human lymphocytes. The genotoxic evaluation of the tested materials, either separately or in combination, for the detection of micronuclei (MN) in the cytoplasm of interphase cells, was performed using the cytokinesis block micronucleus (CBMN) assay. A comparative analysis of the genotoxicity and cytotoxicity reveals that in the tested concentrations, the [MWCNTs + LHA] mixture is more genotoxic and slightly more cytotoxic than the [MWCNTs + HALP] mixture. MN induction observed in human lymphocytes demonstrates that humic substances enhance the genotoxic effects of MWCNTs. In addition, the present data highlight aso far unforeseenpotential genotoxic effect as the result of both clastogenic and aneugenic actions of the particular mixtures on human lymphocytes.Environ. Sci.: Nano This journal is A genotoxicity mechanism of multi-walled carbon nanotubes (MWCNTs) interacting with humic acids (HAs) is revealed. The interfacial properties of MWCNT-HA formations were characterized with ATR-FTIR, Atomic Force Microscopy and Dynamic Light Scattering. Using natural and synthetic/metal-free humic polymers, the mechanisms of colloidal dispersion are correlated with the revealed genotoxicity. Moreover, the geno-vs. cytotoxicity phenomena are quantitatively distinguished. These phenomena originate from the action of humic macromolecules as "chaperones" that shuttle MWCNTs into the cell compartments.

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Section: Significant Enhancement Of the Genotoxic Effect By Mwcnts + Hamentioning

confidence: 99%

Induction of micronuclei by multi-walled carbon nanotubes interacting with humic acids in cultured human lymphocytes

Vidali

Bletsa

Kouloumpis

et al. 2016

Environ. Sci.: Nano

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“…More recently, photochemical oxidation processes using ultrasound irradiation (Stapleton et al, 2006) and photolytic/photocatalytic techniques (Stapleton et al, 2008; Stapleton et al, 2010) have also been applied. Reaction intermediates have been thoroughly analysed (Vlastos et al, 2010) because they are not innocuous. For example, 2‐pyridinol has been found as the main byproduct in the photolytic degradation of 2CP (Stapleton et al, 2009b).…”

Section: Resultsmentioning

confidence: 99%

Hydrolysis of imidazole and 2‐chloropyridine under subcritical and supercritical water conditions

et al. 2012

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Imidazole and 2-chloropyridine were used as model molecules to investigate the acid hydrolysis kinetics of agrochemicals in high-temperature water in a batch reactor system at 28 MPa. Pseudo-first-order hydrolysis reaction rate constants for the acid hydrolysis of Imidazole and 2-chloropyridine were determined in the temperature ranges 200-600 and 400-575 • C, respectively, at 28 MPa. Rate constants for both compounds increased with temperature with a local maximum observed at around 400 • C due to changes in the physical properties of the solvent. Imidazole and 2-chloropyridine conversions of 0.95 and 0.99999 were respectively attained at the highest temperature after 30 min of reaction.

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“…A mild hypotonic treatment with 3:1 solution of Ham's medium and milli-q H 2 O was left for 3 min at room temperature which was followed by 10 min fixation (for at least 3 times) with a fresh 5:1 solution of methanol/acetic acid. Cells were stained for 10 min with 7% Giemsa, as described by Vlastos et al (2010). In total, 2000 binucleated (BN) cells with preserved cytoplasm were scored per experimental point (1000 cells per culture of each donor) to calculate the MN frequency according to standard criteria (Fenech, 1997).…”

Section: Cbmn Assay In Human Lymphocytes In Vitromentioning

confidence: 99%

Is physicochemical evaluation enough to characterize olive mill waste compost as soil amendment? The case of genotoxicity and cytotoxicity evaluation

Chowdhury

Konstantinou

Damati

et al. 2015

Journal of Cleaner Production

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Genotoxicity study of photolytically treated 2-chloropyridine aqueous solutions

Cited by 23 publications

References 33 publications

Induction of micronuclei by multi-walled carbon nanotubes interacting with humic acids in cultured human lymphocytes

Induction of micronuclei by multi-walled carbon nanotubes interacting with humic acids in cultured human lymphocytes

Hydrolysis of imidazole and 2‐chloropyridine under subcritical and supercritical water conditions

Is physicochemical evaluation enough to characterize olive mill waste compost as soil amendment? The case of genotoxicity and cytotoxicity evaluation

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