Genotoxicity, oxidative stress and lysozyme induction in Clarias gariepinus chronically exposed to water-soluble fraction of burnt tire ash

Iheanacho, Stanley; Adeolu, Adewale I.; Nwose, Roseline; Ekpenyong, Joshua; Offu, Peter; Amadi-Eke, Akunna; Iheanacho, Angus C.; Ogunji, Johnny O.

doi:10.1007/s10646-021-02474-7

Cited by 17 publications

(3 citation statements)

References 53 publications

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“…The hyperglycemia in petroleum hydrocarbons-exposed fish is compatible with that observed in Prochilodus lineatus exposed to water-soluble fractions of gasoline 41 , implying a compensatory reactivity to deal with the extensive metabolic requirements and subsequent stress 39 . This secondary stress response could be due to the augmented output of cortisol mobilizing glucose from its cellular stores by activating gluconeogenesis and glycogenolysis pathways to deal with the extra energy requests 42 .…”

Section: Discussionsupporting

confidence: 65%

“…The rise in the activity of hepatic metabolizing enzymes following the exposure to hydrophobic components of gasoline corresponds to the findings in Clarias gariepinus cultivated in aquaria contaminated with benzene 22 . This outcome could be due to stimulation of gluconeogenesis from amino acid precursors in intoxicated fish 39 . It also could point to an interruption of intrahepatic and extrahepatic bile passage and hepatobiliary breakdown 40 .…”

Section: Discussionmentioning

confidence: 99%

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Prefeeding of Clarias gariepinus with Spirulina platensis counteracts petroleum hydrocarbons-induced hepato- and nephrotoxicity

Sayed,

Khalil,

Alghriany

et al. 2024

Sci Rep

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Petroleum aromatic hydrocarbons are considered one of the most dangerous aquatic pollutants due to their widespread across water bodies, persistence, and extension to the food chain. To our knowledge, there hasn’t been any research investigating the hepatorenoprotective effects of Spirulina platensis (SP) against toxicity induced by these environmental toxicants in fish. Thus, we decided to explore its potential safeguarding against benzene and toluene exposure in adult Clarias gariepinus. To achieve this objective, fish were divided into five groups (60 per group; 20 per replicate). The first group served as a control. The second and third groups were intoxicated with benzene and toluene at doses of 0.762 and 26.614 ng/L, respectively for 15 days. The fourth and fifth groups (SP + benzene and SP + toluene, respectively) were challenged with benzene and toluene as previously mentioned following dietary inclusion of SP at a dose of 5 g/kg diet for 30 days. The marked increase in liver metabolizing enzymes, glucose, total protein, albumin, globulin, albumin/globulin ratio, and creatinine confirmed the hepato- and nephrotoxic impacts of benzene and toluene. These outcomes were coupled with cytopathological affections and excessive collagen deposition. The incorporation of SP in ration formulation, on the contrary, restored the previously mentioned toxicological profile due to its antioxidant and cytoprotective attributes. Regardless of SP intervention, the renal tissues still displayed histo-architectural lesions, because of insufficient dose and timeframe. Additional research will be required to identify the ideal SP remediation regimen.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Prefeeding of Clarias gariepinus with Spirulina platensis counteracts petroleum hydrocarbons-induced hepato- and nephrotoxicity

Sayed,

Khalil,

Alghriany

et al. 2024

Sci Rep

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show abstract

“…Fish is an important bio-indicator to measure the toxicological impacts of diverse xenochemical-induced toxicity (Iheanacho et al 2021;Iheanacho et al 2022). Freshwater sh, C. carpio is a hardy and disease-resistant organism, and hence can be adopted as a candidate for ecotoxicological assays.…”

Section: Introductionmentioning

confidence: 99%

Documentation of phytochemicals, bio-toxicity and haemato-physiological responses at sub-lethal concentrations of Parthenium hysterophorus hydroethanolic extract in Cyprinus carpio: a concept of waste valorization as a phyto-ichthyotoxin

Khan

Sharma

Sonkar

et al. 2023

Environ Sci Pollut Res

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In the present study, phytoextraction was performed through aqueous, alcoholic and hydroethanolic (80%) solvents followed by phytochemical pro ling and evaluation of median lethal concentration (LC 50 ) of hydroethanolic extract in Common carp, Cyprinus carpio. The haemato-immunological and biochemical response was evaluated at sub-lethal concentrations (T1: 0.395 mg l -1 and T2: 0.79 mg l -1 and control: devoid of extract) at three intervals (24, 48 and 96 h). The study revealed the presence of toxic constituents in extracts namely saponin, rotenone, tannin and alkaloid. Moreover, phytochemical typing exhibited the superior ability of hydroethanolic solvent and the extract was chosen for further biological activities. The anti-bacterial assay revealed the inhibitory capacity, whereas, phyto-haemagglutination revealed clumping of blood cells due to parthenium extract exposure. The haemagglutination limit test revealed the minimum concentration of extract causes agglutination was 1/96 and the haemolytic activity result exhibited clear lysis of sh RBCs. LC 50 of parthenium was found to be 18.99 mg l -1 . The study revealed that signi cant (p < 0.05) reduction in haematoimmunological indices alongside serum biochemical parameters. The results presented in the study emphasise locally available weed plant gajar ghas, P. hysterophorus as a non-chemical phyto-ichthyotoxin.

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Toxicological insight of magnetite nanogel: neuro-ethological, hepato-renal, antioxidant, and histopathological traits in Clarias gariepinus

Kamel,

Ahmed,

Elsayyad

et al. 2024

Aquacult Int

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Assessment of acute toxicity of magnetic nanogel (MNG) is crucial to conclude the safe applicable dose and to warrant its application in aquaculture. Therefore, the current study is a novel step to assess behavior, neuro-stress response, hepato-renal, oxidative, and histopathological variations produced by MNG’ acute toxicity in Clarias gariepinus. Two experiments were conducted: the first was a determination of the 96-h lethal concentration 50 (LC50) of MNG in C. gariepinus. Meanwhile, the second was an assessment of the toxicological impacts of three different concentrations of MNG in C. gariepinus following a 10-day exposure period and a subsequent 10-day depuration trial. One hundred and eighty fish were allotted to four groups exposed to 0, 1/10, 1/8, or 1/5 96-h LC50 of MNG. The outcomes exhibited that 96-h LC50 of MNG for C. gariepinus was 44 mg/L. The subjected group to MNG induced a concentration-dependent elevation in the serum values of cortisol, alanine transaminase, aspartate transaminase, urea, and creatinine following MNG exposure. Marked elevation in the oxidative stress indicators (catalase (CAT), glutathione S-transferase activity (GST), and superoxide dismutase (SOD)) was also evident. Meanwhile, the value of the neurological biomarker, acetylcholinesterase (AChE), was markedly reduced in a concentration-dependent way. These biochemical changes were complemented by pathological alterations in the hepato-renal architecture. Interestingly, in response to the 10-day depuration period, most of the tested parameters were eliminated in C. gariepinus exposed to 1/10 of LC50. Conclusively, MNG can induce numerous adverse effects only at higher doses (1/5 and 1/8 of LC50). Meanwhile, the lowest tested concentration of MNG (1/10 of LC50) was safe for application in aquaculture practices with only mild disruptions in the bio-indices. In addition, a retrieval period of 10 days was sufficient to renovate these alterations only in fish exposed to the same concentration.

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Genotoxicity, oxidative stress and lysozyme induction in Clarias gariepinus chronically exposed to water-soluble fraction of burnt tire ash

Cited by 17 publications

References 53 publications

Prefeeding of Clarias gariepinus with Spirulina platensis counteracts petroleum hydrocarbons-induced hepato- and nephrotoxicity

Prefeeding of Clarias gariepinus with Spirulina platensis counteracts petroleum hydrocarbons-induced hepato- and nephrotoxicity

Documentation of phytochemicals, bio-toxicity and haemato-physiological responses at sub-lethal concentrations of Parthenium hysterophorus hydroethanolic extract in Cyprinus carpio: a concept of waste valorization as a phyto-ichthyotoxin

Toxicological insight of magnetite nanogel: neuro-ethological, hepato-renal, antioxidant, and histopathological traits in Clarias gariepinus

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