Genotoxicity of urban air particulate matter: Correlations between mutagenicity data, airborne micropollutants, and meteorological parameters

Crebelli, Riccardo; Fuselli, Sergio; Baldassarri, Luigi Turrio; Ziemacki, Giovanni; Carere, A.; Benigni, Romualdo

doi:10.1080/09603129509356830

Cited by 22 publications

(10 citation statements)

References 39 publications

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“…Firstly, this study confirms previous investigations (Crebelli et al 1992(Crebelli et al , 1994) which highlighted, as seasonal, the variation in air mutagenicity level resulting mainly from the increased content of organic matter in airborne particles. This effect, inversely related to ambient temperature, dominates on more subtle variations in the specific mutagenic activity of particle extracts during the cold season (Barale et al 1991).…”

Section: Discussionsupporting

confidence: 91%

Volatile organic compounds (VOCs) and air mutagenicity: Results of one year monitoring at an urban site

Fuselli

Benigni

Conti

et al. 1995

International Journal of Environmental Health Research

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The concentrations of four volatile organic compounds (VOCs: benzene, toluene, ethylbenzene and xylenes) and the levels of inhalable (< 10 µm) airborne particles were monitored during 1 year at a site with intense vehicular traffic in the city of Rome. VOCs as well as airborne particulate matter were sampled every alternate day and pooled in fortnightly samples representative of the first and second half of each month. Some meteorological parameters (mean temperature, heliophany, air pressure and relative humidity) were concurrently recorded. Air particulate extracts were tested for mutagenicity in the Salmonella reversion system with tester strain TA98. Air mutagenicity levels were compared to air concentrations of benzene and alkylbenzenes, putative indicators of vehicular traffic, in order to elucidate their interrelationships. The results of multivariate statistical analyses show that seasonal variations in air mutagenicity are mainly dependent on the increased content of organic matter in airborne particles, possibly resulting from the increased deposition rate of semivolatile compounds with low ambient temperature. A weaker association was observed between air mutagenicity level and VOCs concentrations.

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Section: Discussionsupporting

confidence: 91%

Volatile organic compounds (VOCs) and air mutagenicity: Results of one year monitoring at an urban site

Fuselli

Benigni

Conti

et al. 1995

International Journal of Environmental Health Research

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“…These concentrations are in accordance with the ambient air levels recorded in Europe during recent years, which ranged from 0.1 to 20 ng/m 3 (34,35). Air temperature plays an important role, modulating particulate pollutant air levels and the composition of the organic matter adsorbed on air particles (36). The shift of this distribution towards the particulate phase at low temperatures is one of the explanations for the increase in the relative abundance found for pyrene during the winter season (37,38).…”

Section: Discussionmentioning

confidence: 99%

Exposure to carcinogenic air pollutants among policemen working close to traffic in an urban area

Maı̂tre¹,

Soulat²,

Masclet³

et al. 2002

Scand J Work Environ Health

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“…As it has been proved, there is an inverse relationship between the mutagenicity and ambient temperature, and the maximum mutagenicity values are reached under winter conditions [12].…”

Section: Salmonella Assaymentioning

confidence: 99%

Cytotoxicity and genotoxicity properties of particulate matter fraction 2.5 μm

et al. 2017

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Abstract. In the ambient is more than 2,000 chemical substances, some of them are absorbed on the surface of the particulate matter and may causes many health problems. Air pollution is responsible for more than 3.2 million premature deaths which classifies it as a second place environmental risk factor. Especially dangerous for health are polycyclic aromatic hydrocarbons and their nitro-and amino derivatives which shows mutagenic and carcinogenic properties. Air pollutions were also classified by International Agency for Research on Cancer to group which carcinogenic properties on human were proved by available knowledge. Air pollutions, including particulate matter are one of the biggest problem in Polish cities. World Health Organization in report published in May 2016 set many of Polish cities on the top of the list most polluted in European Union. The article presents results of mutagenicity, genotoxicity and cytotoxicity researches conducted on a particulate matter fraction 2.5 µm collected during all year long in Wroclaw agglomeration. The material were collected on filters using high-flow air aspirator and extracted using dichloromethane. Additionally it was fractionated into 2 parts containing: all pollutants and only polycyclic aromatic hydrocarbons. Dry residue of this fractions were dissolving in DMSO and tested using biological methods. Biological methods include mutagenicity properties which are investigated by Salmonella assay (Ames assay). Other biological method was comet assay and 4 parameter cytotoxicity test PAN-I assay. Results of the conducted experiments shows differences in mutagenic, genotoxic and cytotoxic properties between seasons of collection and between volume of dust pollutions fractions. The worst properties shows particles collected in autumn and winter season and this containing only polycyclic aromatics hydrocarbons. Results showed also some correlations in results obtained during different methods and properties.

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Genotoxicity of urban air particulate matter: Correlations between mutagenicity data, airborne micropollutants, and meteorological parameters

Cited by 22 publications

References 39 publications

Volatile organic compounds (VOCs) and air mutagenicity: Results of one year monitoring at an urban site

Volatile organic compounds (VOCs) and air mutagenicity: Results of one year monitoring at an urban site

Exposure to carcinogenic air pollutants among policemen working close to traffic in an urban area

Cytotoxicity and genotoxicity properties of particulate matter fraction 2.5 μm

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