Genotoxicity of Some Essential Oils Frequently Used in Aromatherapy

Mezzoug, Nadya; Idaomar, Mohamed; Baudoux, Dominique; Debauche, Pascal; Liemans, V; Zhiri, Abdesselam

doi:10.4236/abb.2016.72008

Cited by 4 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nausea can cause disruption of daily activities, such conditions bring pregnant women to unpleasant situations. Seeing the effects of nausea can be said that nausea is one of the problems in the life of pregnant women who forced them to use various ways to prevent the occurrence of nausea in pregnancy (16,17) .…”

Section: Discussionmentioning

confidence: 99%

Aromatherapy Cajuput Oil for Emesis Gravidarum

Kusparlina¹

2019

View full text Add to dashboard Cite

Emesis Gravidarum can be very disturbing activity and impact on the maternal and fetal maternal obstacles. The incidence of emesis gravidarum in the world is 70-80% of the number of pregnant women, one non-pharmacological method that can reduce the intensity of nausea vomiting by cajuput oil. This research purposes to determine whether there is an influence of aromatherapy cajuput oil on emesis gravidarum in the first trimester pregnant women. This research used cross sectional approach. Population in this research is the first trimester pregnant woman which amounted to 17 pregnant women taken by using total sampling. The data were analyzed by univariate analysis with independent variable frequency distribution and dependent and bivariate analysis using Wilcoxon sign rank test. P-value value: 0.000 and alpha 0.005 Statistical test results show that cajuput oil has a significant effect on emesis gravidarum intensity. It can be concluded that there is an effect of Aromatherapy cajuput oil on emesisgravidarum in the first trimester pregnant woman, so it is expected that cajuput oil can be one of alternative non pharmacological method that can help to reduce the intensity of emesis gravidarum. Keywords: Pregnancy, Emesis gravidarum, Cajuput oil

show abstract

Section: Discussionmentioning

confidence: 99%

Aromatherapy Cajuput Oil for Emesis Gravidarum

Kusparlina¹

2019

View full text Add to dashboard Cite

show abstract

“…In parallel with the in vivo antioxidant evaluation, the Wistar rats' liver and kidney samples were used for determining the selected YY and CCP EOs' antigenotoxic activities by means of the comet assay (Tables 6-8) [128,165]. While, to the best of the authors' knowledge, no genotoxicity and/or antigenotoxicity study has been reported for YY EO, the CCP EO isolated from the bark of Cinnamomum burmanii was already assessed using doxorubicininduced Chinese Hamster Ovary (CHO-K1) cells using micronucleus assay [166], Ames Salmonella reversion assay, Bacillus subtilis DNA-repair test (Rec-assay), Escherichia coli WP2uvrA reversion test [167], and Drosophila melanogaster Somatic Mutation and Recombination Test [168]. Herein, the antigenotoxicity of EOs was evaluated against the rCCl 3 OO • that could cause the formation of rMDA and transform the DNA into the aberrant adducts, like M 1 G, M 1 A, and M 1 C (Scheme 2, purple pathway, bold arrows, 28, 29 and 30), which root the transversions and transitions of bases and, upon the quantitative ring-opening, ultimately form N 2 -oxopropenyl-dG, N 2 -oxopropenyl-dA, and N 2 -oxopropenyl-dC adducts (Scheme 2, purple pathway, bold arrows, 31, 32 and 33), leading to the DNA-DNA interstrand cross-links or DNA-protein inter-strand crosslinks [169] to which the comet assay is sensitive [128,165].…”

Section: Eos Antigenotoxic Activity In Vivomentioning

confidence: 99%

In Vitro Antioxidant and In Vivo Antigenotoxic Features of a Series of 61 Essential Oils and Quantitative Composition–Activity Relationships Modeled through Machine Learning Algorithms

Mladenović,

Astolfi,

Tomašević

et al. 2023

Antioxidants

View full text Add to dashboard Cite

The antioxidant activity of essential oils (EOs) is an important and frequently studied property, yet it is not sufficiently understood in terms of the contribution of EOs mixtures’ constituents and biological properties. In this study, a series of 61 commercial EOs were first evaluated as antioxidants in vitro, following as closely as possible the cellular pathways of reactive oxygen species (ROS) generation. Hence, EOs were assessed for the ability either to chelate metal ions, thus interfering with ROS generation within the respiratory chain, or to neutralize 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and lipid peroxide radicals (LOO•), thereby halting lipid peroxidation, as well as to neutralize 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid cation radicals (ABTS•+) and hydroxyl radicals (OH•), thereby preventing the ROS species from damaging DNA nucleotides. Showing noteworthy potencies to neutralize all of the radicals at the ng/mL level, the active EOs were also characterized as protectors of DNA double strands from damage induced by peroxyl radicals (ROO•), emerging from 2,2′-azobis-2-methyl-propanimidamide (AAPH) as a source, and OH•, indicating some genome protectivity and antigenotoxicity effectiveness in vitro. The chemical compositions of the EOs associated with the obtained activities were then analyzed by means of machine learning (ML) classification algorithms to generate quantitative composition–activity relationships (QCARs) models (models published in the AI4EssOil database available online). The QCARs models enabled us to highlight the key features (EOSs’ chemical compounds) for exerting the redox potencies and to define the partial dependencies of the features, viz. percentages in the mixture required to exert a given potency. The ML-based models explained either the positive or negative contribution of the most important chemical components: limonene, linalool, carvacrol, eucalyptol, α-pinene, thymol, caryophyllene, p-cymene, eugenol, and chrysanthone. Finally, the most potent EOs in vitro, Ylang-ylang (Cananga odorata (Lam.)) and Ceylon cinnamon peel (Cinnamomum verum J. Presl), were promptly administered in vivo to evaluate the rescue ability against redox damage caused by CCl4, thereby verifying their antioxidant and antigenotoxic properties either in the liver or in the kidney.

show abstract