Genotoxicity of polar and apolar extracts obtained from Qualea multiflora and Qualea grandiflora

Santos, Fábio V.; Nasser, Ana Lúcia Martiniano; Biso, Fabiana Izilda; Moreira, Leonardo Marmo; Santos, Vanessa J. S. V.; Vilegas, Wagner; Varanda, Eliana Aparecida

doi:10.1016/j.jep.2011.08.062

Cited by 9 publications

(7 citation statements)

References 31 publications

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“…A sample was considered mutagenic when MI ≥ 2 for at least one of the tested doses and if the response was dose dependent. 21,22…”

Section: Methodsmentioning

confidence: 99%

“…2 for at least one of the tested doses and if the response was dose dependent. 21,22 Animals A total of 56 male mice of Swiss line (26 -30 g) with six weeks were housed individually in plastic cages for one week prior to the experiment. The animals were fed with a standard commercial diet (Purina w Labina, Campinas -SP, Brazil) and control ad libitum.…”

Section: Ames Mutagenicity Assaymentioning

confidence: 99%

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Evaluation of healing wound and genotoxicity potentials from extracts hydroalcoholic of Plantago major and Siparuna guianensis

Thomé

Santos

et al. 2012

Exp Biol Med (Maywood)

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Despite the large use of the Plantago major and Siparuna guianensis in traditional medicine, there are no studies demonstrating the effectiveness from extracts of these plants in the healing process by the present methodology. This study reported the effects and toxicity of the P. major and S. guianensis extracts in the wound healing compared with a commercial product used in Brazil by macroscopic and microscopic analysis. Following injury in cervical dorsal area of the mice, the extract from P. major and S. guianensis and ointment was applied after an injury in cervical dorsal area of the mice. Wound healing rates were calculated at 4, 9, 15 and 21 d after the wounding, and tissues were obtained on the ninth day for histological analysis. Moreover, mutagenic assay of extracts was performed. Mutagenicity studies carried out with plant extracts showed not mutagenic with or without metabolic activations. Reduction of the wound area occurred earlier in mice treated with P. major and control treatment. On the 15th day, the complete wound closure occurred in P. major-treated wounds. Throughout ointment and S. guianensis treatment it was not observed the wound closured. Microscopic analyses of the wound, on the ninth day, showed the more efficient formation of the neoepithelium and skin appendages in animals treated with S. guianensis and P. major, while ointment treatment presented no re-epithelialization and absent skin appendages in wound. Thus, P. major extract showed good effects on wound healing processes rendering it a promising candidate for the treatment of wounds what also justified its traditional usage in wound treatment.

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“…A sample was considered mutagenic when MI ≥ 2 for at least one of the tested doses and if the response was dose dependent. 21,22…”

Section: Methodsmentioning

confidence: 99%

Section: Ames Mutagenicity Assaymentioning

confidence: 99%

Evaluation of healing wound and genotoxicity potentials from extracts hydroalcoholic of Plantago major and Siparuna guianensis

Thomé

Santos

et al. 2012

Exp Biol Med (Maywood)

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“…É característica de cerrado sensu stricto, ocorrendo nos estados da Bahia, Goiás, Minas Gerais, Mato Grosso, Mato Grosso do Sul, Piauí, Tocantins e São Paulo (Barônio 2012). É utilizada na medicina popular para o tratamento de úlceras, gastrites, amebíase, diarreia com sangue, cólicas intestinais e inflamações (Santos et al 2011). Em relação a sua fenologia, segundo Silvério e Lenza (2010), em cerrado sensu stricto, a espécie apresenta floração retardada (floração durante a estação chuvosa) e sua polinização é entomófila (Rissi & Cavassan 2013), a dispersão de sementes ocorre tanto no período seco quanto chuvoso e a síndrome de dispersão é anemocórica, pois as sementes são oblongas com ala lateral (Rissi & Cavassan 2013).…”

Section: Espécie Estudadaunclassified

FENOLOGIA REPRODUTIVA E VEGETATIVA DE Qualea multiflora MART. EM CERRADÃO

et al. 2020

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O conhecimento advindo da fenologia vegetal em ecossistemas naturais promove o entendimento da biodiversidade, produtividade, organização das comunidades vegetais e sobre as interações das plantas com a fauna, sendo de grande importância em programas de conservação. Entretanto, informações fenológicas de algumas espécies são insuficientes, este é o caso de Qualea multiflora Mart. Diante do exposto, este estudo teve o objetivo de descrever a sua fenologia reprodutiva e vegetativa em fitofisionomia de Cerradão, Estado de Goiás, Brasil. Para tal, foram marcados 15 indivíduos que foram visitados mensalmente entre julho de 2016 e junho de 2018 e os eventos reprodutivos (botão floral, antese, fruto imaturo e fruto maduro) e vegetativos (broto foliar, folha jovem, folha adulta e senescência) foram registrados. A intensidade e sincronia foram avaliadas e testada a sazonalidade e correlação de Spearman da fenologia com variáveis climáticas locais. A floração ocorreu na transição do período seco para o chuvoso e durante as chuvas. A frutificação foi registrada durante todos os meses de estudo e a maturação dos frutos na época mais seca. A brotação foliar, produção de folhas e senescência ocorreram na maioria dos meses de observação, com maior intensidade em meses secos e quentes. A folhagem adulta esteve presente durante todo o estudo. Este estudo evidencia que mesmo que Q. multiflora apresente comportamento fenológico semelhante ao já encontrado na literatura para espécies arbóreas do cerradão, há algumas particularidades, principalmente no corpo vegetativo. Palavras-chave: floração; frutificação; pau-terra-liso; sazonalidade; sincronia. REPRODUCTIVE AND VEGETATIVE PHENOLOGY OF Qualea multiflora MART. IN CERRADÃO. Knowledge of plant phenology in natural ecosystems promotes the understanding of biodiversity, productivity, organization of plant communities, and interactions between plants and fauna, being of great importance in conservation programs. However, phenological information of some species is insufficient, which is the case of Qualea multiflora Mart. In this context, this study describes reproductive and vegetative phenology

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“…(QG), a large tree belonging to the Vochysiaceae family is one of the most common tree species in the Brazilian Cerrado [1]. Many studies using QG extracts have reported several therapeutic aspects such as the cure and prevention of gastric mucosa damage, central nervous system depressant, analgesic effect, anticonvulsant, anti-inflammatory, antimicrobial, and active in the treatment of wounds [2,3,4,5,6]. These researches show that the QG has components with important pharmacological activities, however, studies involving the plant in question are still scarce.…”

Section: Introductionmentioning

confidence: 99%

Effects of Qualea grandiflora Extract on the Expression of MMP-14 and HIF-1α in Cultured Fibroblasts and Preosteoblasts

Oliveira

Tokuhara

Oliveira

et al. 2021

Braz. arch. biol. technol.

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Genotoxicity of polar and apolar extracts obtained from Qualea multiflora and Qualea grandiflora

Cited by 9 publications

References 31 publications

Evaluation of healing wound and genotoxicity potentials from extracts hydroalcoholic of Plantago major and Siparuna guianensis

Evaluation of healing wound and genotoxicity potentials from extracts hydroalcoholic of Plantago major and Siparuna guianensis

FENOLOGIA REPRODUTIVA E VEGETATIVA DE Qualea multiflora MART. EM CERRADÃO

Effects of Qualea grandiflora Extract on the Expression of MMP-14 and HIF-1α in Cultured Fibroblasts and Preosteoblasts

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