Genotoxicity assessment of human peripheral Lymphocytes induced by thallium(I) and thallium(III)

Rodríguez‐Mercado, Juan José; Mosqueda-Tapia, Gabriela; Altamirano-Lozano, Mario

doi:10.1080/02772248.2017.1307377

Cited by 28 publications

(11 citation statements)

References 33 publications

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“…Thallium (Tl) is a toxic metal that may pose a serious threat to human and environmental health, both as monovalent Tl(I) and as trivalent Tl(III) (Rodríguez-Mercado et al, 2017). Over the common environmental pH-Eh range, Tl mainly occurs in the Tl(I) oxidation state (Vink, 1993).…”

Section: Introductionmentioning

confidence: 99%

Thallium and co-genetic trace elements in hydrothermal Fe-Mn deposits of Central Spain

Garrido

García-Guinea

López-Arce

et al. 2020

Science of The Total Environment

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Section: Introductionmentioning

confidence: 99%

Thallium and co-genetic trace elements in hydrothermal Fe-Mn deposits of Central Spain

Garrido

García-Guinea

López-Arce

et al. 2020

Science of The Total Environment

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“…Decreases in the mitotic index and replicative index in vitro were demonstrated by Rodríguez-Mercado et al. [ 20 , 21 ], who suggested that Tl +1 induces genetic damage and is cytotoxic. The genotoxic effects of Tl 2 SO 4 [600 μM] in this in vivo study are evidence of the potential effects of Tl 2 SO 4 that have been reported in in vitro studies at [1.8–369.8 μM] [ 21 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…[ 20 , 21 ], who suggested that Tl +1 induces genetic damage and is cytotoxic. The genotoxic effects of Tl 2 SO 4 [600 μM] in this in vivo study are evidence of the potential effects of Tl 2 SO 4 that have been reported in in vitro studies at [1.8–369.8 μM] [ 21 , 42 ]. The differences found in this study might be attributed to the compound's absorption distribution, metabolism, and excretion (ADME) of this metal salt when administered in vivo .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, very few studies evaluate Tl compound genotoxicity in vitro and in vivo [ 19 ]. We assessed the in vitro genotoxic effect of TlCH 3 COO and Tl 2 SO 4 in human leucocytes cultured at [0.5, 1, 5, 10, 50 and 100 μg/mL] based on structural and numerical chromosome aberrations, sister chromatid exchange and comet assays (pH > 13 and 12.1) and showed that both salts have effects on the mitotic index, exert cytotoxic, cytostatic, and clastogenic activity and cause DNA damage [ 20 , 21 ]. Given these previous results, the aim of this study is to gain insight into the possible in vivo genotoxicity of TlCH 3 COO and Tl 2 SO 4 through an alternative animal test that uses the insect Drosophila melanogaster to realize the wing somatic mutation and recombination test (SMART) standard cross (ST) with Cyp450 basal levels [ 22 ] by pairwise comparison with negative dissolvent control results.…”

Section: Introductionmentioning

confidence: 99%

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Genotoxicity and cytotoxicity evaluation of two thallium compounds using the Drosophila wing somatic mutation and recombination test

Reyes-Rodríguez

Santos-Cruz

García-Castro

et al. 2021

Heliyon

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Thallium (Tl) is a heavy and toxic metal and a byproduct of several human activities, such as cement production, mining, and coal combustion. Thallium is found in fruits, vegetables, and animal fodder with high Tl contamination; therefore, it is an environmental pollution issue and a toxicological contamination problem for human beings and other organisms when exposed to it. The mutagenic potential of Tl and its compounds is controversial, and there are few in vivo studies on its effects. We conducted the animal bioassay Drosophila wing somatic mutation and recombination test (SMART) to test for genotoxicity and assessed the genotoxic effects of Tl acetate (TlCH 3 COO) and Tl sulfate (Tl 2 SO 4 ) on Drosophila melanogaster. Third instar larvae from the SMART standard cross (ST) were fed Tl acetate [0.2, 2, 20, 200, 600 and 1200 μM] and Tl sulfate [0.2, 2, 20, 200, and 600 μM]. Hexavalent chromium [CrO 3 , 500 μM] served as the positive control, and Milli-Q water served as the negative control. Only the high Tl 2 SO 4 [600 μM] concentration resulted in genotoxicity with 87.6% somatic recombination, and both salts disrupted cell division of wing imaginal disc cells, showing the expected cytotoxic effects. Genotoxic risks due to high metal levels by bioaccumulation of Tl þ1 or its compounds require further evaluation with other in vivo and in vitro assays.

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“…Thallium (Tl) is a metal that can exhibit high potential cytotoxicity and genotoxicity in its two main oxidation states (I and III) to humans (Rodríguez-Mercado et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Historical roasting of thallium- and arsenic-bearing pyrite: Current Tl pollution in the Riotinto mine area

López-Arce

Garrido

García-Guinea

et al. 2019

Science of The Total Environment

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Samples of an open-air pyrite roasting heap from the 19 th century in the Riotinto mine area (SW Spain) and surrounding sediments and soil along a seasonal surface runoff channel were analyzed to study thallium (Tl) phase transformations during historical roasting of Tl-bearing arsenian pyrite, secondary weathering processes, Tl dispersion and current environmental pollution. Results from Electron Probe Microanalyses (EPMA) indicate an even distribution of Tl in pyrite grains of an ore sample (22 mg kg-1 total Tl), suggesting that Tl is incorporated in the pyrite structure rather than in discrete Tl-sulfide microparticles. The roasting residue (122 mg kg-1 total Tl) consists mainly of hematite. EPMA suggested that Tl in the roasting residue and contaminated soil was cooccuring with Fe oxide particles, with a mean Tl point concentration of 0.12% in samples from the roasting residues. Total concentrations of Tl in soil samples decrease with distance from the roasting heap to 14 mg kg-1. X-ray absorption near-edge structure (XANES) spectra collected on pyrite roasting residue and a soil sample suggest that most Tl is Tl(I) substituting K in jarosite. Sequential extractions show that most Tl (85-99%) in the soil and sediment samples is concentrated in the residual fraction and, thus, is rather strongly bound. Lastly, water extracts indicate that colloidal particles (i.e. <1 µm size) may contribute to the dispersion of Tl around and away from the roasting heaps.

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Genotoxicity assessment of human peripheral Lymphocytes induced by thallium(I) and thallium(III)

Cited by 28 publications

References 33 publications

Thallium and co-genetic trace elements in hydrothermal Fe-Mn deposits of Central Spain

Thallium and co-genetic trace elements in hydrothermal Fe-Mn deposits of Central Spain

Genotoxicity and cytotoxicity evaluation of two thallium compounds using the Drosophila wing somatic mutation and recombination test

Historical roasting of thallium- and arsenic-bearing pyrite: Current Tl pollution in the Riotinto mine area

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