Genotoxicity and toxicological effects of acrylamide on reproductive system in male rats

Yang, Hye Jin; Lee, Sang Hyun; Jin, Yong; Choi, Jin Hyang; Han, Chang Hoon; Lee, Mun Han

doi:10.4142/jvs.2005.6.2.103

Cited by 63 publications

(38 citation statements)

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“…The TEM also showed degenerative changes in the spermatogenic epithelium as well as in Leydig cells. These data were in agreement with results of previous studies [5,6,24]. Yang et al [6] used different doses of acrylamide to test its reproductive toxicity on rats.…”

Section: Discussionsupporting

confidence: 92%

“…These data were in agreement with results of previous studies [5,6,24]. Yang et al [6] used different doses of acrylamide to test its reproductive toxicity on rats. They reported that the changes were dose-dependent and that they were marked with the highest dose (60 mg/kg/day).…”

Section: Discussionsupporting

confidence: 92%

“…Thickening of the boundary tissue of the spermatogenic epithelium, which was also reported by Yang et al [6], occurs most probably secondary to the toxic effect of acrylamide, which leads to inflammatory reaction and fibrosis. This toxic effect also stimulates the release of chemical mediators after tissue damage, resulting in vascular congestion [30].…”

Section: Discussionmentioning

confidence: 79%

“…Curcumin was dissolved in distilled water and was given by oral intubation. Group 3 animals were treated with acrylamide (Winlab Ltd., UK) at a dose of 60 mg/kg body weight/day for 5 days [6]. Acrylamide (supplied as a powder) was dissolved in distilled water and was also given by oral intubation.…”

Section: Methodsmentioning

confidence: 99%

“…Reproductive toxicity of acrylamide has been tested in animals [5,6]. In addition to the occurrence of testicular damage, DNA breakage during specific germ cell stages was also reported [7].…”

Section: Introductionmentioning

confidence: 96%

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Curcumin protects against testicular damage and genotoxicity induced by acrylamide in male albino mice

Gouda

Khalil

Naim

2011

The Egyptian Journal of Histology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 3 more Smart Citations

Curcumin protects against testicular damage and genotoxicity induced by acrylamide in male albino mice

Gouda

Khalil

Naim

2011

The Egyptian Journal of Histology

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Toxicological effect of emodin in mouse testicular gene expression profile

Oshida

Hirakata

Maeda

et al. 2011

J of Applied Toxicology

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Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a herbal medicine extracted from the rhizomes of Rheum palmatum, and is known as an inhibitor of casein kinase II (CK2). The CK2α' knockout mice are known to be male-infertile; however, there have been no reports on the toxicity of emodin in male reproductive organs/tissues. To evaluate the toxicological effects of emodin on differential gene expression profiles of the testis as compared with acrylamide, mice were orally administered emodin and acrylamide for 5 days at a dose of 1000 and 50 mg kg(-1) per day, respectively, and euthanized 24 h after the final administration. Both chemicals induced hypospermatogenesis, eosinophilic change and apoptosis of germ cell. A DNA microarray analysis showed that the IGF-1 receptor signaling was most closely related to the above testicular toxicity induced by emodin, and the RhoA regulation, TGF/WNT and cytoskeletal remodeling, TNFR1 signaling and adenosine A2A receptor signaling were commonly associated with the two chemicals. We selected 36 genes associated with CK2, apoptosis and spermatogenesis and determined their expression by quantitative reverse transcription-polymerase chain reaction (qPCR). Both chemicals perturbed the expression of genes associated with CK2. Genes related to spermatogenesis were also affected, as evidenced by hypospermatogenesis, and eosinophilic change and apoptosis of germ cell. The results suggest that emodin causes testicular toxicity, including apoptosis with related the IGF-1 receptor signaling pathway, and the two chemicals commonly affect CK2, spermatogenesis and sperm motility via four pathways, such as TNFR1 signaling.

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Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12 weeks

Takami

Imai

Cho

et al. 2011

J of Applied Toxicology

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Acrylamide (AA), a neurotoxic, testicular toxic, genotoxic and carcinogenic chemical, has been reported to be formed in processed food, and sensitivity to AA intoxication in childhood is a concern. In the present study, to clarify the general toxicological profile of AA in juvenile rats, subchronic toxicity was evaluated in F344 rats administered AA in the drinking water at 0 (control), 10, 20 and 40 ppm, presented to the dams (three per group) immediately after the birth of their litters, through lactation (3 weeks), and directly to the offspring in their drinking water after weaning for a further 9 weeks (12 weeks total). Treatment with AA caused a decrease in body weights in 20 and 40 ppm F(1) females, compared with the controls. Average AA intake throughout the treatment period for the 10, 20 and 40 ppm groups after weaning was equivalent to 1.0, 2.1 and 4.4 mg kg(-1) body weight per day, respectively, in males and 1.2, 2.5 and 4.9 mg kg(-1) body weight per day, respectively, in females. No toxicologically significant organ weight changes were observed. AA-induced histopathological changes were limited to focal degeneration and necrosis of the seminiferous epithelium in the testes and desquamated epithelium in the ducts of epididymides, noted only in 40 ppm males. Taken together with previous reports, juvenile rats are not necessarily more susceptible to AA-induced toxicity as compared with young adults.

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Genotoxicity and toxicological effects of acrylamide on reproductive system in male rats

Cited by 63 publications

References 0 publications

Curcumin protects against testicular damage and genotoxicity induced by acrylamide in male albino mice

Curcumin protects against testicular damage and genotoxicity induced by acrylamide in male albino mice

Toxicological effect of emodin in mouse testicular gene expression profile

Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12 weeks

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