Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats

Silva, Victor Hugo Pereira da; Moura, Carolina Foot Gomes de; Ribeiro, Flávia Andressa Pidone; César, Augusto; Pereira, Camilo Dias Seabra; Silva, Marcelo José Dias; Vilegas, Wagner; Ribeiro, Daniel Araki

doi:10.1007/s11356-014-3261-5

Cited by 8 publications

(6 citation statements)

References 50 publications

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“…After drying the slides, they were stained with Giemsa (MerckÔ, Darmstadt, Germany). For liver MN test, paraffin sections (3 mm) were stained by Feulgen and counterstained with Fast Green (Sigma-AldrichÔ) (da Silva et al, 2014). A total of one thousand polychromatic erythrocytes or hepatocytes were analyzed per animal (de Moura et al, 2014).…”

Section: Micronucleus Testmentioning

confidence: 99%

Genotoxicity and mutagenicity induced by acute crack cocaine exposure in mice

Yujra

Moretti

Cláudio

et al. 2015

Drug and Chemical Toxicology

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Section: Micronucleus Testmentioning

confidence: 99%

Genotoxicity and mutagenicity induced by acute crack cocaine exposure in mice

Yujra

Moretti

Cláudio

et al. 2015

Drug and Chemical Toxicology

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“…The classification was based on score levels, considering the area of necrosis and changes such as eosinophilia, the presence of intracytoplasmic vacuoles, congestive vessels, and loss of structure established by Silva et al [37] and described in Table 6.…”

Section: Methodsmentioning

confidence: 99%

Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet

et al. 2019

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Juçara berry is a potential inflammatory modulator, rich in dietary fiber, fatty acids, and anthocyanins. Considering this, we evaluated the high-fat diet (HFD) intake supplemented with different doses of freeze-dried juçara pulp on the TLR4 pathway. Twenty-seven male Wistar rats with ad libitum access to food and water were divided into four experimental groups: control standard chow group (C); high-fat diet control group (HFC); high-fat diet juçara 0.25% group (HFJ0.25%); and high-fat diet juçara 0.5% group (HFJ0.5%). The inflammatory parameters were analyzed by ELISA and Western blotting in liver and retroperitoneal adipose tissue (RET). The HFJ0.25% group had the energy intake, aspartate transaminase (AST) levels, and liver triacylglycerol accumulation reduced; also, the tumor necrosis factor α (TNF-α) and TNF receptor-associated factor 6 (TRAF6) expression in RET were reduced. However, there were no changes in other protein expressions in liver and adipose tissue. Adiposity and pNFκBp50 had a positive correlation in HFC and HFJ0.5%, but not in the C group and HFJ0.25%. The necrosis hepatic score did not change with treatment; however, the serum (AST) levels and the hepatic triacylglycerol were increased in HFC and HFJ0.5%. These results demonstrated that one week of HFD intake triggered pro-inflammatory mechanisms and liver injury. Additionally, 0.25% juçara prevented inflammatory pathway activation, body weight gain, and liver damage

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“…Hepatic apoptotic bodies (A.B.) were quantified under fluorescence microscopy as preconized by Ong et al and described by Da Silva et al…”

Section: Methodsmentioning

confidence: 99%

Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats

Samelo

Medeiros

Cavalcante

et al. 2019

Environmental Toxicology

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Arsenic (As) can contaminate air, soil, water, and organisms through mobilization of natural mineralogical deposits or anthropogenic actions. Inorganic‐As compounds are more toxic and widely available in aquatic environments, including drinking water reservoir catchments. Since little is known about its effects on prepubertal mammals, the present study focused on it. Hence, As was administered through drinking water to male Wistar rats from postnatal day 23 to 53. Negative control group received vehicle only (filtered water); As 1 group received AsNaO2 at 0.01 mg L−1 and As2 group received AsNaO2 at 10 mg L−1. It was investigated hepatic and renal toxicity of AsNaO2 (ie, histopathology and apoptosis analysis), as well as its mutagenicity (ie, micronucleus test in liver and bone marrow), cytotoxicity (ie, frequency and type of erythrocytes in blood), and genotoxicity (ie, comet assay in blood). Also, As determination was performed in hepatic and renal tissues. Data obtained revealed that immature organisms present a pattern of arsenic accumulation similar to that observed in adults, suggesting similarity in metabolic processes. In addition, liver showed to be an important target tissue for As toxicity in these experimental conditions, exhibiting infiltrate of defense cells, DNA damages, and increased apoptosis rates.

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Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats

Cited by 8 publications

References 50 publications

Genotoxicity and mutagenicity induced by acute crack cocaine exposure in mice

Genotoxicity and mutagenicity induced by acute crack cocaine exposure in mice

Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet

Low concentrations of sodium arsenite induce hepatotoxicity in prepubertal male rats

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