Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane

Belitsky, Gennady A.; Lytcheva, T.A.; Khitrovo, I. A.; Safaev, R. D.; Vs, Zhurkov; Vyskubenko, I.F.; Sytshova, L. P.; Salamatova, Olga; Feldt, E.G.; Khudoley, V. V.; Mizgirev, I. V.; Khovanova, E M; Ugnivenko, E.G.; Tanirbergenov, T B; Malinovskaya, K. I.; Revazova, Yu. A.; Ingel, Faina I.; Bratslavsky, V. A.; Terentyev, A. B.; Shapiro, A. A.; Williams, Gary M.

doi:10.1007/bf00756766

Cited by 10 publications

(2 citation statements)

References 29 publications

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“…Only 1,2-dibromopropane was mutagenic and showed similar mutagenic activity with and without activation. Belitsky et al 40) studied the genotoxicity of 1,2-dibromopropane (DBP) and 1,1,3-tribromopropane (TBP) in seven assays. DBP was active in DNA repair in primary rat hepatocyte culture, the somatic mutation and recombination assay in Drosophilia melanogaster, and micronucleus formation assay in mouse.…”

Section: Comparison Of Toxicity In Related Bromohydrocarbonsmentioning

confidence: 99%

A Review on Toxicity of 2‐Bromopropane: Mainly on its Reproductive Toxicity

Takeuchi

Ichihara

Kamijima

1997

Journal of Occupational Health

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A Review on Toxicity of 2‐Bromopropane : Mainly on its Reproductive Toxicity: Yasuhiro Takeuchi, et al. Department of Hygiene, Nagoya University School of Medicine—2‐Bromopropane has been used mostly as an intermediate for medicines, pesticides and other chemicals in closed systems. Recently it has come to be used as an alternative solvent in open systems instead of ozone layer depleting chlorofluorocarbons. An outbreak of reproductive and hematopoietic disorders occurred in workers exposed to solvents containing 2‐bromopropane in a Korean factory in 1995. After that some animal experiments revealed that 2‐bromopropane has a severe toxic effect on the female and male reproductive organs and hematopoietic organs. We reviewed the toxicity of 2‐bromopropane based on the recent data obtained in epidemiological surveys and animal experiments. Toxicities of structurally related bromopropanes were compared with that of 2‐bromopropane and its risk assessment was discussed. The conclusions are as follows: 1. 2‐Bromopropane has a specific reproductive and hematopoietic toxicity in both sexes in humans and experimental animals. 2. It could impair the testes, especially spermatogonia in males. 3. It could impair the ovarian function, resulting in a disturbed estrous cycle and loss of oocytes in females. 4. It could impair the bone marrow, resulting in pancytopenia. 5. It has a weak potent mutagenicity in bacterial mutation assays. 6. A risk assessment suggests that around 0.3‐10 ppm might be recommended as an occupational exposure limit for 2‐bromopropane.

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Section: Comparison Of Toxicity In Related Bromohydrocarbonsmentioning

confidence: 99%

A Review on Toxicity of 2‐Bromopropane: Mainly on its Reproductive Toxicity

Takeuchi

Ichihara

Kamijima

1997

Journal of Occupational Health

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“…However, brominated and mixed chlorinated and brominated propanes have been examined in a number of assays. Positive results in sister chromatid exchange and bacterial reversion assays have been observed with di-and tribromopropanes and DBCP (Belitsky et al, 1994;Lag et al, 1994;Ratpan and Plaumann, 1988). However, the addition of fluorine to the propane molecule tends to stabilize and reduce the genotoxic potential of these compounds.…”

Section: Discussionmentioning

confidence: 99%

Developmental Toxicity and Genotoxicity Studies of 1,1,1,3,3,3-Hexachloropropane (HCC-230fa) in Rats

Brock¹

2003

Toxicological Sciences

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The potential developmental toxicity and the in vitro and in vivo genotoxicity of HCC-230fa were assessed. In the developmental toxicity study, groups of 25 mated Crl:CD(R)(SD)BR rats were exposed (whole body) by inhalation to HCC-230fa over days 7-21 of gestation; the day of confirmed mating was designated as gestation day 1 (GD1). Exposures were 6 h per day at concentrations of 0, 0.5, 2.5, or 25 ppm. Body weight, food consumption, and clinical observation data were collected during the study. On day 22 of gestation, the dams were euthanized and examined grossly. The fetuses were removed and subsequently weighed, sexed, and examined for external, visceral, head, and skeletal alterations. Evidence of maternal and developmental toxicity was observed at 25 ppm and was noted as significant, compound-related reductions in mean maternal body weight, weight change, and food consumption. Significant fetal effects also were observed at 25 ppm as compound-related reductions in mean fetal weight and increased fetal malformations (filamentous tail, situs inversus, absent vertebrae) and variations (rudimentary cervical ribs, delayed sternebral ossification). There was no evidence of either maternal or developmental toxicity at 0.5 or 2.5 ppm. The genotoxicity of HCC-230fa was examined in a bacterial reversion assay and in erythrocyte micronucleus studies in two species by different routes of administration. No increases in the number of revertants were observed in the bacterial reversion assay. In one micronucleus study, HCC-230fa was administered by inhalation to rats as part of a 90-day study at doses indicated above. For the second study, ICR mice were given a single ip dose at 0, 166, 330, or 660 mg/kg. In both micronucleus studies, a significant increase in micronucleated erythrocytes was observed. The results of these studies suggest that HCC-230fa affects rapidly dividing cells and may have long-term consequences for occupational exposures.

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1,2‐Dibrom‐3‐chlorpropan [MAK Value Documentation in German language, 2002]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 34. Lieferung, Ausgabe 2002 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Genotoxicity and carcinogenicity testing of 1,2-dibromopropane and 1,1,3-tribromopropane in comparison to 1,2-dibromo-3-chloropropane

Cited by 10 publications

References 29 publications

A Review on Toxicity of 2‐Bromopropane: Mainly on its Reproductive Toxicity

A Review on Toxicity of 2‐Bromopropane: Mainly on its Reproductive Toxicity

Developmental Toxicity and Genotoxicity Studies of 1,1,1,3,3,3-Hexachloropropane (HCC-230fa) in Rats

1,2‐Dibrom‐3‐chlorpropan [MAK Value Documentation in German language, 2002]

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