Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice

Lin, Yan; Lin, Meng-Hsuan; Yeh, Ti-Yen; Lai, Yi-Syuan; Lu, Kuan-Hung; Huang, Huai-Syuan; Peng, Fu-Chuo; Liu, Shing‐Hwa; Sheen, Lee‐Yan

doi:10.1016/j.jtcme.2022.05.001

Cited by 10 publications

(3 citation statements)

References 40 publications

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“…It provides evidence of treatment-induced alteration in hematology, biochemical, and reflect organ morphology and histopathology. Generally this kind of the study helps for assessing the toxicity profile of a test substance (Loha et al, 2019;Lin et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Safety evaluation of a proprietary ayruveda-based polyherbal preparation (arthralgex) used for arthritis

Ukkinadka,

Badanthadka

2024

Braz. J. Biol.

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Arthralgex is a proprietary polyherbal preparation used in clinics to treat rheumatoid arthritis for decades. Its safety evaluation has not been reported. The study is aimed at evaluating the safety of arthralgex using Wistar rats, as per OECD guidelines. According to OECD 407, rats of either gender were separated into six groups (n= 6 each). The dose of arthralgex was decided based on an acute toxicity study. Under the treatment group, separate set of rats received arthralgex in three dose levels like - low, medium, and high (200, 400 & 800 mg/kg/day; p.o for 28 days). Satellite groups received high dose (800 mg/kg/day, p.o for 28 days), and control group received equal volume of vehicle. On day 28, blood samples were collected to estimate hematology and biochemistry parameters. Subsequently, rats were euthanized to collect organs for weighing and histopathology. Satellite groups were maintained for an additional 14 days post-treatment to assess toxicity reversibility and euthanized on day 43. Arthralgex did not show any signs of toxicity or major change in body weight in the acute toxicity study. Arthralgex has no significant adverse effect on general health status as confirmed by body weight, feed intake, hematology, biochemistry, urine analysis, internal organs, relative organ weight, and histopathological evaluation after 28 day treatment. Arthralgex could be considered safe for short-term treatment. Present findings may help researchers in dose fixing for sub-chronic and chronic toxicity studies, which is essential for safety evaluation for long-term use.

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Section: Discussionmentioning

confidence: 99%

Safety evaluation of a proprietary ayruveda-based polyherbal preparation (arthralgex) used for arthritis

Ukkinadka,

Badanthadka

2024

Braz. J. Biol.

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“…Previous preclinical toxicity studies suggested that garlic and its derivatives have a credible safety profile. 86,87 Thus, it provides prospective value for developing functional foods and dietary supplements for garlic in clinical practice.…”

Section: Summary Of Evidencementioning

confidence: 99%

Evidential support for garlic supplements against diabetic kidney disease: a preclinical meta-analysis and systematic review

Jiang,

Li,

Yue

et al. 2024

Food Funct.

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“…It has been demonstrated that garlic extract at higher doses is clastogenic in mice (Lin et al., 2022). Garlic toxicity in the liver can result from overconsumption (Ozma et al., 2022).…”

Section: Garlic (Allium Sativum)mentioning

confidence: 99%

Potential of Allium sativum in blood pressure control involves signaling pathways: A narrative review

et al. 2023

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The use of food products and functional foods to manage and treat several health conditions is expanding globally. Garlic (Allium sativum) consumption is commonly used for its potential therapeutic functions in numerous cardiometabolic disorders, including hypertension. The proposed blood pressure–reducing effects of garlic after its consumption influence several metabolic pathways, resulting in potentially beneficial health outcomes. The first postulated mechanism is nitric oxide (NO) activation, leading to vasodilation. Furthermore, garlic consumption was also shown to promote vasodilation by suppressing the renin–angiotensin–aldosterone system (RAAS) and the formation of prostaglandins, suppressing angiotensin‐converting enzyme activity. The mechanism of garlic‐related vasodilation is related to its high sulfur‐containing content associated with forming hydrogen sulfides (H2S). The H2S binds to and activates vascular ATP‐sensitive potassium channels (kATP), leading to hyperpolarization, which induces vasodilation. This review summarizes garlic's features and the mechanical paths that could contribute to blood pressure control.

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Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice

Cited by 10 publications

References 40 publications

Safety evaluation of a proprietary ayruveda-based polyherbal preparation (arthralgex) used for arthritis

Safety evaluation of a proprietary ayruveda-based polyherbal preparation (arthralgex) used for arthritis

Evidential support for garlic supplements against diabetic kidney disease: a preclinical meta-analysis and systematic review

Potential of Allium sativum in blood pressure control involves signaling pathways: A narrative review

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