Genotoxic properties of materials used for endoprostheses: Experimental and human data

Qin, Hongmin; Herrera, Denise E.; Liu, Dianfeng; Chen, Chao-Qian; Nersesyan, Armen; Mišík, Miroslav; Knasmueller, Siegfried

doi:10.1016/j.fct.2020.111707

Cited by 2 publications

(2 citation statements)

References 130 publications

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“…The authors indicated and early genotoxicity in the bladder and cautioned the use of metal-on-metal implants for their genotoxicity per se and their wear debris. In a recent review by Qin et al (22) , which investigated data from experimental and human data on the genotoxicity of materials used in endoprostheses, induction of chromosomal aberrations was reported with certain implant materials in vitro and in vivo; this damage was accredited to the release of metal ions and particles from the implant. The authors concluded that patients hosting artificial implants could be at a higher risk of DNA damage that could probably initiate carcinogenicity.…”

Section: Resultsmentioning

confidence: 99%

Review of Selected Orthopaedic Implants for their Genotoxicity Potential

George¹,

Naveen²,

Murali³

et al. 2023

IJST

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Background/Objectives: Orthopaedic implants are intended to be part of a biological system for a considerable amount of time, hence its essential to test for their genotoxicity. This review investigates the genotoxicity associated with various orthopaedic implant materials. Methods: We collected genotoxicity studies conducted on twenty different types of orthopedic implant materials in our laboratory from 2015 to 2022, along with their accompanying reports. Based on these reports, the implants were categorized into groups according to their materials of construction. This paper includes a thorough evaluation of the findings from the genotoxicity tests obtained from the Bacterial Reverse Mutation Assay, Chromosomal Aberration Assay, and Micronucleus Assay conducted on orthopedic implant materials in our laboratory. Findings: A total of 20 different orthopedic implants were tested in our laboratory for their genotoxic potential. These 20 implants were made of four different materials viz., titanium alloys, ultra-high molecular weight polyethylene, stainless steel and Cobalt chromium molybdenum alloys. All these implants were tested on Ames test, chromosome aberration test and or in vivo micronucleus tests. None of the materials showed any evidence of mutagenicity. Novelty: This is the first open paper highlighting the results of genotoxicity testing of selected orthopedic implant materials.

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Section: Resultsmentioning

confidence: 99%

Review of Selected Orthopaedic Implants for their Genotoxicity Potential

George¹,

Naveen²,

Murali³

et al. 2023

IJST

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“…These additives increase the strength properties of polyethylene, but there is a need for additional research aimed at determining the biocompatibility of the resulting composite materials when they are used as one of the parts of enoprostheses. There are approaches to increase the wear resistance of UHMWPE by applying various protective coatings on its surface based on polyrroles with carbon nanotubes [28], metal compositions [29], organic and organometallic compounds [30], but the resulting material also requires additional research in terms of its compatibility with the human body during its implantation [30].…”

Section: Introductionmentioning

confidence: 99%

Effect of Atmospheric Pressure Plasma in Inert Gases on Orthopedic Ultra-High Molecular Weight Polyethylene

Василец

Velyaev

Mosunov

et al. 2022

KEM

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In this work, studies have been conducted on the treatment of ultrahigh molecular weight polyethylene (UHMWPE), which is one of the structural materials used in the endoprostheses, with atmospheric pressure plasma in high-purity argon and helium. For this purpose, an installation consisting of a high-voltage pulsed generator, voltage and current measuring devices and a reaction quartz chamber with electrodes, in which UHMWPE samples were placed, was developed and constructed. It is shown that processing under certain conditions in Ar plasma and He at atmospheric pressure leads to the appearance of terminal double bonds in the structure of the processed polyethylene, as evidenced by the appearance of a peak of 880 cm-1, in the attenuated total reflection IR spectrum. This peak is observed both for samples treated in helium and argon plasma. The formation of such bonds is a consequence of the generation of active radicals in the UHMWPE surface layer under plasma treatment, which, during recombination, also form intermolecular crosslinking, thereby increasing the strength characteristics of the material as a whole. The modification of the surface of the treated samples begins within the first minute of processing and reaches its peak values 10-20 minutes after treatment in plasma.

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Genotoxic properties of materials used for endoprostheses: Experimental and human data

Cited by 2 publications

References 130 publications

Review of Selected Orthopaedic Implants for their Genotoxicity Potential

Review of Selected Orthopaedic Implants for their Genotoxicity Potential

Effect of Atmospheric Pressure Plasma in Inert Gases on Orthopedic Ultra-High Molecular Weight Polyethylene

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