Genotoxic effects of pesticide fipronil in somatic and generative cells of mice

Lovinskaya, A. V.; Kolumbayeva, S. Zh.; Коломиец, О. Л.; Абилев, С. К.

doi:10.1134/s1022795416050070

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…However, in the other organs this result was not observed. Previous studies suggested that fipronil generate genotoxic damage more through oxidative stress [ [48] , [49] , [50] ].The regression analysis showed that genotoxicity of fipronil is more related to CYP1A gene expression in the liver. This organ had the most increase of CYP1A gene expression with increasing fipronil dose and time of exposure.…”

Section: Discussionmentioning

confidence: 99%

“…There is no report about direct effect of fipronil metabolite (fipronil-desulfinyl and fipronil-sulfone), with higher toxicity compared to fipronil, on DNA. However, Lovinskaya et al [ 50 ] suggested that the increase in DNA damage in the mice liver cells 24 h after injection of fipronil compared to 6 h is probably due to the metabolism of fipronil and the formation of fipronil sulfone in these cells. Thus, this result might be related to CYP1A biotransformation activity, and fipronil metabolite might generate DNA damage directly.…”

Section: Discussionmentioning

confidence: 99%

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CYP1A gene expression as a basic factor for fipronil toxicity in Caspian kutum fish

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CYP1A gene expression as a basic factor for fipronil toxicity in Caspian kutum fish

et al. 2018

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An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Pisa

Goulson

Yang

et al. 2017

Environ Sci Pollut Res

190

144

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New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous Worldwide Integrated Assessment (WIA) in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods. Little new information has been gathered on soil organisms. The impact on marine and coastal ecosystems is still largely uncharted. The chronic lethality of neonicotinoids to insects and crustaceans, and the strengthened evidence that these chemicals also impair the immune system and reproduction, highlights the dangers of this particular insecticidal class (neonicotinoids and fipronil), with the potential to greatly decrease populations of arthropods in both terrestrial and aquatic environments. Sublethal effects on fish, reptiles, frogs, birds, and mammals are also reported, showing a better understanding of the mechanisms of toxicity of these insecticides in vertebrates and their deleterious impacts on growth, reproduction, and neurobehaviour of most of the species tested. This review concludes with a summary of impacts on the ecosystem services and functioning, particularly on pollination, soil biota, and aquatic invertebrate communities, thus reinforcing the previous WIA conclusions .

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Measurement of DNA damage by CellProfiler software in the liver of Caspian white fish exposed to environmental concentrations of fipronil

Ardeshir

Zolgharnien

Movahedinia

et al. 2019

Computational Toxicology

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Genotoxic effects of pesticide fipronil in somatic and generative cells of mice

Cited by 7 publications

References 17 publications

CYP1A gene expression as a basic factor for fipronil toxicity in Caspian kutum fish

CYP1A gene expression as a basic factor for fipronil toxicity in Caspian kutum fish

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Measurement of DNA damage by CellProfiler software in the liver of Caspian white fish exposed to environmental concentrations of fipronil

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