Genotoxic effects of dioxolane and trioxane in mice evaluated by the micronucleus test

Pipoxolan inhibits proliferation of HL‐60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase

“…Our results demonstrate that pipoxolan is most effective in arresting cell cycle progression and inducing apoptosis in HL‐60 cells. It is believed that products containing a dioxolan moiety induce apoptosis of cancer cells 12,13 . Pipoxolan contains a dioxolan moiety and this may explain its induction of apoptosis in HL‐60 cells.…”

“…It is believed that products containing a dioxolan moiety induce apoptosis of cancer cells. 12,13 Pipoxolan contains a dioxolan moiety and this may explain its induction of apoptosis in HL-60 cells.…”

“…Pipoxolan has attracted considerable attention during the past decade because it displays a wide range of biological activities, including as an antispasmodic as well as acting to relieve painful digestion and migraine headache 10,11 . Many products containing a dioxolan moiety have been reported to induce apoptosis in cancer cells 12,13 . Therefore, the aim of the present study was to explore the effect of pipoxolan on cytotoxicity in a human leukaemia cell line and to investigate the molecular mechanism through which pipoxolan induces cell death.…”

“…10,11 Many products containing a dioxolan moiety have been reported to induce apoptosis in cancer cells. 12,13 Therefore, the aim of the present study was to explore the effect of pipoxolan on cytotoxicity in a human leukaemia cell line and to investigate the molecular mechanism through which pipoxolan induces cell death.…”

Methyl acrylate [MAK Value Documentation, 1993]

“…Positive results were obtained in a micronucleus test in male mice given two i.p. doses of 37.5 -300 mg/kg, 24 hours apart [26]. In contrast, a second micronucleus test in the mouse yielded negative results [25].…”