Genotoxic damages in zebrafish submitted to a polymetallic gradient displayed by the Lot River (France)

Comparative genotoxicity of aluminium and cadmium in embryonic zebrafish cells

“…Cadmium is well known to induce oxidative stress, which generates DNA lesions such as base damage and SSBs, both in humans and in fish [20,41]. Indeed, it was suggested that the inhibitory effect of cadmium on BER, NER and MMR repair systems can be involved in a conversion of base damage into numerous SSBs that could be involved in DSB production [8,15].…”

Metal detoxification and gene expression regulation after a Cd and Zn contamination: An experimental study on Danio rerio

“…Also, some studies have demonstrated the absence of MT synthesis in response to metal contamination in the brain of D. rerio . Orieux et al (2011) showed a very rapid response against the oxidative stress involving sod and sodmt genes, in the brain of D. rerio exposed for 3 d to a contaminated site exhibiting Cd concentrations of 11.2 lg L À1 . Their results suggest a fast adaptive response in the brain to limit metallic damages.…”

Recovery capabilities of Xenopus laevis after exposure to Cadmium and Zinc

“…Additionally, the induction of the cytoplasmic superoxide dismutase involved in the oxidative stress response was reported. Some authors (Cambier et al, 2010;Orieux et al, 2011) reported recently that mitochondria were the first target of trace metal impacts and that ROS generation could be at the origin of various secondary effects, such as DNA damage, lipid peroxidation or modification of the translation machinery capabilities. In the remaining tissues, the induction of the tap gene is also observed.…”