Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde

Costa, Solange; Coelho, Patrícia; Costa, Carla; Silva, Susana; Mayan, Olga; Santos, Luís S.; Gaspar, Jorge; Teixeira, João Paulo

doi:10.1016/j.tox.2008.07.056

Cited by 111 publications

(89 citation statements)

References 78 publications

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“…After adjustment for age and other confounding factors, we found that MN frequencies from samples taken before (67 worker study) and after (67 and 178 worker studies) the workday FA exposure were significantly increased with the number of work years, consistent with the findings of Costa et al 12) and Jiang et al 11) in 48 pathology/anatomy workers and 151 plywood workers, respectively. However, in contrast to the findings of the two earlier studies by Costa et al 15) and Jiang et al…”

Section: Discussioncontrasting

confidence: 75%

“…On the other hand, Ying et al 14) found that the frequencies of lymphocyte micronuclei in students did not significantly increase after exposure to 0.508 mg/m 3 FA over an 8-week period of anatomy classes. Moreover, debates about the correlation between chromosome damage and FA exposure levels are also found in the literature 15,16) . Contradictory results were also reported for DNA-protein crosslinks (DPCs), another important genetic damage that has been extensively evaluated in FA-exposed rodents and mammalian cells in vitro 17−20) .…”

Section: Occupational Exposure To Formaldehyde and Genetic Damage In mentioning

confidence: 99%

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Occupational Exposure to Formaldehyde and Genetic Damage in the Peripheral Blood Lymphocytes of Plywood Workers

Lin

Guo

Yi³

et al. 2013

Journal of Occupational Health

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Occupational Exposure to Formaldehyde and Genetic Damage in the Peripheral Blood Lymphocytes of Plywood Workers: Dafeng LIN, et al. Institute of Occupational Medicine and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, China— Objectives We sought to clarify the association of occupational formaldehyde exposure with DNA strand breaks, chromosome damage and DNA‐protein crosslinks (DPCs) in the peripheral blood (PB) lymphocytes of plywood workers. Methods We determined Olive tail moment (OTM) values, micronucleus (MN) frequencies and DPC rates of the PB lymphocytes in 178 workers divided into control and lower and higher exposure groups according to their current formaldehyde exposure levels and examined the association of each end point with formaldehyde exposure levels and with the number of work years. We also examined each end point in an additional 62 workers before and after an 8‐hour formaldehyde exposure for validating the association. Results OTM values increased significantly in the two exposure groups compared with those in the control group (p<0.05 for both) and were associated with increasing formaldehyde exposure levels =0.002), while MN frequencies increased with (ptrend increasing numbers of work years (p<0.001). The trend dynamic study showed that OTM values and DPC rates increased after an 8‐hour formaldehyde exposure compared with those before the exposure (p<0.001, p=0.019, respectively), that, in a dose‐dependent manner, OTM values were associated with formaldehyde exposure levels during work hours (p=0.005) and that MN frequencies before and after the 8‐hour work exposure were associated with numbers of work years (p=0.029, p<0.001, respectively). Conclusions We found a dose‐response relationship between the current formaldehyde exposure levels and DNA strand breaks and between duration of exposure and chromosome damage in the PB lymphocytes of plywood workers.

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Section: Discussioncontrasting

confidence: 75%

Section: Occupational Exposure To Formaldehyde and Genetic Damage In mentioning

confidence: 99%

Occupational Exposure to Formaldehyde and Genetic Damage in the Peripheral Blood Lymphocytes of Plywood Workers

Lin

Guo

Yi³

et al. 2013

Journal of Occupational Health

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“…Polymorphism of the repair genes XRCC1 and XRCC3 can contribute to increase the genetic damage in susceptible subjects with chronic exposure to cytostatic drugs (Laffon et al 2005;Cornetta et al 2008). Formaldehyde, an endogenous cellular aldehyde often used in pathology and anatomy laboratories is a well-known human mutagenic carcinogen although evidence of genotoxic effects in human PBLs is insufficient (Costa et al 2008;Jakab et al 2010). In our study a significant increase of CA yields and apoptotic capacity was observed among the exposed donors .…”

Section: Gene and Environmental Interactionsmentioning

confidence: 44%

“…Speit et al (2000) investigating the base excision and crosslink repairs suggested that a disturbed excision repair can have more severe consequences with regards of CA formation after formaldehyde exposure than a disturbed crosslink repair. Costa et al (2008) found no significant effect of genetic polymorphism of DNA repair enzymes on the investigated genotoxic end points (micronuclei, SCE, and primary DNA lesions determined by the comet assay).…”

Section: Gene and Environmental Interactionsmentioning

confidence: 69%

Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment

Tompa¹,

Major²,

Jakab³

2011

DNA Repair and Human Health

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“…It is widely found in indoor living or working environments. (1)(2)(3)(4) FA is also produced in natural processes. For example, it is a natural metabolite of living organisms and is found in bodily fluids, tissues, and cells.…”

Section: Introductionmentioning

confidence: 99%

Direct Measurement of Gaseous Formaldehyde from Food with a Fiber-Optic Biochemical Gas Sensor (Bio-sniffer)

Toma¹,

Miyajima²,

Shin‐ichi³

et al. 2016

Sensors and Materials

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In this work, we assessed the ability of a fiber-optic biochemical gas sensor (bio-sniffer) to directly and nondestructively measure gaseous formaldehyde (FA) released from food. In the biosniffer, formaldehyde dehydrogenase (FALDH) was immobilized in a hydrophilic fluoropolymer membrane in which an enzymatic reaction producing nicotinamide adenine dinucleotide (NADH) occurred. The resultant NADH was excited with ultraviolet (UV) light irradiated from the optical fiber end in the bio-sniffer and the emitted fluorescence was coupled back to the fiber end and detected. In experiments to characterize the bio-sniffer using standard gaseous FA samples, the capability of continuous measurement (a coefficient of variation of 3.4% for five successive measurements) and high sensitivity (a limit of detection of 1.1 ppb) were validated. Then a demonstration of direct gaseous FA from food was carried out using Shiitake mushrooms (Lentinula edodes). Owing to the use of the enzyme, the bio-sniffer was able to selectively measure FA, and clear differences in FA concentrations were observed depending on the state of the mushrooms, i.e., dried, rehydrated with deionized water or with γ-GTPase inhibitor. These results indicated that the bio-sniffer allowed the direct monitoring of FA naturally produced in food or the evaluation of the metabolism of living organisms.

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Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde

Cited by 111 publications

References 78 publications

Occupational Exposure to Formaldehyde and Genetic Damage in the Peripheral Blood Lymphocytes of Plywood Workers

Occupational Exposure to Formaldehyde and Genetic Damage in the Peripheral Blood Lymphocytes of Plywood Workers

Application of UV-Induced Unscheduled DNA-Synthesis Measurements in Human Genotoxicological Risk Assessment

Direct Measurement of Gaseous Formaldehyde from Food with a Fiber-Optic Biochemical Gas Sensor (Bio-sniffer)

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