Genotoxic and mutagenic effects of mycotoxins: a review

Aydın, Muhsin; Rencüzoğulları, Eyyüp

doi:10.31594/commagene.633418

Cited by 2 publications

(2 citation statements)

References 320 publications

(279 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For QSAR mutagenicity model development, the endpoint Bacterial Reverse Mutation Test (Ames test) (OECD test guideline 471) was selected ( Figure 7 ), considered the first outcome to assess the possible mutagenicity of a substance [ 67 , 68 ]. We scanned several high-quality databases (Carcinogenic Potency Database CEBS, CCRIS Mutagenicity assay, Vega, QSAR Toolbox, EFSA OpenFoodTox, ECVAM, etc.)…”

Section: Methodsmentioning

confidence: 99%

“…We scanned several highquality databases (Carcinogenic Potency Database CEBS, CCRIS Mutagenicity assay, Vega, QSAR Toolbox, EFSA OpenFoodTox, ECVAM, etc.) as well as the scientific literature [68] for data of the compounds of our previously generated mycotoxin database. For each compound, CAS number, isomeric SMILES, and experimental data expressed as active (1) or inactive (0) were compiled in a table.…”

Section: Mycotoxin Mutagenicity Qsar Modelmentioning

confidence: 99%

See 1 more Smart Citation

MicotoXilico: An Interactive Database to Predict Mutagenicity, Genotoxicity, and Carcinogenicity of Mycotoxins

Tolosa,

Serrano Candelas,

Vallés Pardo

et al. 2023

Toxins

View full text Add to dashboard Cite

Mycotoxins are secondary metabolites produced by certain filamentous fungi. They are common contaminants found in a wide variety of food matrices, thus representing a threat to public health, as they can be carcinogenic, mutagenic, or teratogenic, among other toxic effects. Several hundreds of mycotoxins have been reported, but only a few of them are regulated, due to the lack of data regarding their toxicity and mechanisms of action. Thus, a more comprehensive evaluation of the toxicity of mycotoxins found in foodstuffs is required. In silico toxicology approaches, such as Quantitative Structure–Activity Relationship (QSAR) models, can be used to rapidly assess chemical hazards by predicting different toxicological endpoints. In this work, for the first time, a comprehensive database containing 4360 mycotoxins classified in 170 categories was constructed. Then, specific robust QSAR models for the prediction of mutagenicity, genotoxicity, and carcinogenicity were generated, showing good accuracy, precision, sensitivity, and specificity. It must be highlighted that the developed QSAR models are compliant with the OECD regulatory criteria, and they can be used for regulatory purposes. Finally, all data were integrated into a web server that allows the exploration of the mycotoxin database and toxicity prediction. In conclusion, the developed tool is a valuable resource for scientists, industry, and regulatory agencies to screen the mutagenicity, genotoxicity, and carcinogenicity of non-regulated mycotoxins.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Mycotoxin Mutagenicity Qsar Modelmentioning

confidence: 99%

MicotoXilico: An Interactive Database to Predict Mutagenicity, Genotoxicity, and Carcinogenicity of Mycotoxins

Tolosa,

Serrano Candelas,

Vallés Pardo

et al. 2023

Toxins

View full text Add to dashboard Cite

show abstract

Estrogenic, androgenic, and genotoxic activities of zearalenone and deoxynivalenol in in vitro bioassays including exogenous metabolic activation

Yu,

Oskarsson,

Alexander

et al. 2024

Mycotoxin Res

View full text Add to dashboard Cite

Zearalenone (ZEN) and deoxynivalenol (DON) and their derivatives are well-known mycotoxins, which can occur not only in crops but also in water bodies, including drinking water sources. In vitro bioassays can be used to detect biological effects of hazardous compounds in water. To this, when studying biological effects and toxicity in vitro, metabolism is important to consider. In this study, ZEN, α-zearalenol (α-ZEL), DON, 3-acetyl DON, and 15-acetyl DON were evaluated in vitro for hormone receptor–mediated effects (estrogen receptor [ER] and androgen receptor [AR]) and genotoxicity (micronucleus assay) in the presence of an exogenous metabolic activation system (MAS). The ER bioassay proved to be a highly sensitive method to detect low concentrations of the ZEN compounds (EC10 values of 31.4 pM for ZEN, 3.59 pM for α-ZEL) in aqueous solutions. In the presence of the MAS, reduced estrogenic effects were observed for both ZEN compounds (EC10 values of 6.47 × 103 pM for ZEN, 1.55 × 102 pM for α-ZEL). Of the DON compounds, only 3-acetyl DON was estrogenic (EC10 of 0.31 µM), and the effect was removed in the presence of the MAS. Anti-androgenic effects of the ZEN compounds and androgenic effects of the DON compounds were detected in the micromolar range. No induction of genotoxicity was detected for ZEN or DON in the presence of the MAS. Our study highlighted that inclusion of exogenous MAS is a useful tool to detect biological effects of metabolites in in vitro bioassays.

show abstract

Genotoxic and mutagenic effects of mycotoxins: a review

Cited by 2 publications

References 320 publications

MicotoXilico: An Interactive Database to Predict Mutagenicity, Genotoxicity, and Carcinogenicity of Mycotoxins

MicotoXilico: An Interactive Database to Predict Mutagenicity, Genotoxicity, and Carcinogenicity of Mycotoxins

Estrogenic, androgenic, and genotoxic activities of zearalenone and deoxynivalenol in in vitro bioassays including exogenous metabolic activation

Contact Info

Product

Resources

About