Genotoxic and antimicrobial studies of the leaves of Psidium guajava

Ofodile, L. N.; Nwakanma, N. M. C.; Mordi, Michael; Ademolu, Oluwakemi; Ezimoke, Isabella; Owoso, Jokotade

doi:10.5053/ejobios.2013.7.0.8

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…Usman et al (2010) indicated the plant contains essential oils, and this could be responsible for it broad us in treatment by traditional folks. Crude extract from Psidium guajava exhibited similar finding as in the present study (Ofodile et al, 2013;Biswas et al, 2013). Essential oil of Cymbopongon citrates has also been reported as potential source of bacteriostatic, fungistatic and microbicide agents against a wide range of infectious organisms (Soares et al, 2013;Vazirian et al, 2012;Lodhia et al, 2009).…”

Section: Discussionsupporting

confidence: 86%

In vitro antimicrobial activity of Antibact, an herbal medicinal product against standard and clinical bacterial isolates

Mills-Robertson¹,

Onyeka²,

Tay³

et al. 2015

J. Med. Plants Res.

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In vitro antimicrobial activities of ethanol and aqueous "Antibact", herbal products consisting of a combination of the leaves and branches of four different plants were evaluated against twenty one pathogenic bacteria. Saponins, reducing sugars, phenolics, polyuronides, and triterpenes were the major phyto-constituents of both the aqueous and ethanol "Antibact". The LD 50 analysis revealed the products were safe (LD 50 >5000 mg/kg bodyweight) for in vivo use. All the isolates (100%) were resistant to at least five of the 12 antibiotics used in the study. In total, the aqueous "Antibact" inhibited the growth of 5 out of the 21 (23.81%) microbes used with an average zone of inhibition of 9.73 ± 0.35 mm. Thirteen (61.90%) out of the 21 microbes used were susceptible to the ethanol "Antibact", registering an average inhibition zone of 10.80 ± 0.18 mm. In the case of the minimum inhibitory concentration (MIC), the aqueous "Antibact" exhibited MIC range of 4.00 to 32.00 mg/ml and 0.50 to 8.00 mg/ml, while the ethanol "Antibact" recorded MIC range of 2.00 to 8.00 and 1.00 to 2.00 mg/ml for the wild and standard strains, respectively. The average minimum bactericidal concentration (MBC) for the aqueous "Antibact" was 32.00 mg/ml while the ethanol "Antibact" had MBC range of 4.00 to 16.00 mg/ml and 4.00 to 8.00 mg/ml for the wild and standard strains, respectively. In conclusion, both "Antibact" were safe for human use and effective against some pathogenic bacteria in vitro. However, ethanol "Antibact" showed better antimicrobial activity.

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Section: Discussionsupporting

confidence: 86%

In vitro antimicrobial activity of Antibact, an herbal medicinal product against standard and clinical bacterial isolates

Mills-Robertson¹,

Onyeka²,

Tay³

et al. 2015

J. Med. Plants Res.

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“…It is widely accepted that extracts having activities where MIC values are below 8 mg/ml are considered to possess some antimicrobial activity [ 16 , 130 ] and natural products with MIC values below 1 mg/ml are considered noteworthy [ 16 , 131 , 132 ]. Some publications reported antimicrobial activities of Nigerian medicinal plant extracts with MIC less than or equal to 1 mg/ml against selected organisms [ 42 , 49 , 51 , 53 , 54 , 58 , 71 , 103 , 104 , 114 , 121 , 133 , 134 - 148 ] [ Table 1 ]. Inhibitory zone diameter (IZD) is measured in millimeter (mm) when DD or AWD assays is used [ 76 , 149 , 150 ].…”

Section: Antimicrobial Investigation On Nigerian Plant Extractsmentioning

confidence: 99%

Antimicrobial activity of Nigerian medicinal plants

Anyanwu¹,

Okoye²

2017

J Intercult Ethnopharmacol

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Antimicrobial resistance (AMR) is currently one of the major threats facing mankind. The emergence and rapid spread of multi- and pan-drug-resistant organisms (such as vancomycin-, methicillin-, extended-spectrum β-lactam-, carbapenem- and colistin-resistant organisms) has put the world in a dilemma. The health and economic burden associated with AMR on a global scale are dreadful. Available antimicrobials have been misused and are almost ineffective with some of these drugs associated with dangerous side effects in some individuals. Development of new, effective, and safe antimicrobials is one of the ways by which AMR burden can be reduced. The rate at which microorganisms develop AMR mechanisms outpaces the rate at which new antimicrobials are being developed. Medicinal plants are potential sources of new antimicrobial molecules. There is renewed interest in antimicrobial activities of phytochemicals. Nigeria boasts of a huge heritage of medicinal plants and there is avalanche of researches that have been undertaken to screen antimicrobial activities of these plants. Scientific compilation of these studies could provide useful information on the antimicrobial properties of the plants. This information can be useful in the development of new antimicrobial drugs. This paper reviews antimicrobial researches that have been undertaken on Nigerian medicinal plants.

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“…The later study indicated the effectiveness of P. guajava as antibacterial and antifungal activity. Moreover, Ofodile et al [5] described the antimicrobial and genotoxic effects of the P. guajava leaf extracts. The last work mentioned that the leaf ethanolic and the crude water extracts of guava leaf showed stronger antibacterial than antifungal activity, whereas, A. fumigatus was the least susceptible organism to leaf ethanolic extract.…”

Section: Ta B L Ementioning

confidence: 99%

“…Their biological activity in terms of pharmacological study could be related to its major components such as essential oils, flavonoids, carotenoids, polyphenolic compounds, pentacyclic triterpenoids, esters, aldehydes etc. [2,[3][4][5].…”

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In vitro leaves and twigs antimicrobial properties of Psidium guajava L. (Myrtaceae)

2015

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The complex [Cu(en) 2 (H 2 O)](sy) 2 (en)(H 2 O) 2 has been synthesized and characterized by its electronic and vibrational spectra. The molecular structure of the complex has been determined by X-ray diffraction methods. The complex crystallizes in the orthorhombic space group Pnma with unit-cell parameters a = 10.7236 (5), b = 20.4660(10), c = 14.4523(11)Å and Z = 4. In the cation, the Cu(II) ion has a distorted square pyramidal coordination with two bidendate (en) ligands forming the basal plane and a H 2 O molecule in the apical position. The complex cations and syringate anions constitute chains along the b axis in -A-B-A-fashion. The members of the chains are linked by through N-H···O hydrogen bonds. The (en) molecules are responsible for connecting adjacent layers.

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Genotoxic and antimicrobial studies of the leaves of Psidium guajava

Cited by 8 publications

References 20 publications

In vitro antimicrobial activity of Antibact, an herbal medicinal product against standard and clinical bacterial isolates

In vitro antimicrobial activity of Antibact, an herbal medicinal product against standard and clinical bacterial isolates

Antimicrobial activity of Nigerian medicinal plants

In vitro leaves and twigs antimicrobial properties of Psidium guajava L. (Myrtaceae)

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