Genomics offers new possibilities for global health through international collaboration

Williams, Tiffany J.

doi:10.1242/dmm.005215

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…1,2 Scientific leaders suggest that genomic discovery may hold particular promise for improving global health. 3,4 For example, advances in the understanding of the genomes of insect vectors likely will inform the development of more effective vaccines that may lead to widespread improvements in the prevention and control of many infectious diseases in the developing world.…”

Section: Introductionmentioning

confidence: 99%

The Association of Beliefs About Heredity with Preventive and Interpersonal Behaviors in Communities Affected by Podoconiosis in Rural Ethiopia

Ayode

McBride

Heer

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Little is known about how beliefs about heredity as a cause of health conditions might influence preventive and interpersonal behaviors among those individuals with low genetic and health literacy. We explored causal beliefs about podoconiosis, a neglected tropical disease (NTD) endemic in Ethiopia. Podoconiosis clusters in families but can be prevented if individuals at genetically high risk wear shoes consistently. Adults (N = 242) from four rural Ethiopian communities participated in qualitative assessments of beliefs about the causes of podoconiosis. Heredity was commonly mentioned, with heredity being perceived as (1) the sole cause of podoconiosis, (2) not a causal factor, or (3) one of multiple causes. These beliefs influenced the perceived controllability of podoconiosis and in turn, whether individuals endorsed preventive and interpersonal stigmatizing behaviors. Culturally informed education programs that increase the perceived controllability of stigmatized hereditary health conditions like podoconiosis have promise for increasing preventive behaviors and reducing interpersonal stigma.

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Section: Introductionmentioning

confidence: 99%

The Association of Beliefs About Heredity with Preventive and Interpersonal Behaviors in Communities Affected by Podoconiosis in Rural Ethiopia

Ayode

McBride

Heer

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Early Detection of Pediatric Cardiomyopathy Disease Using Window Based Correlation Method from Gene Micro Array Data

Jayanthi

Mahesh

Arthi³

et al. 2021

Journal of Sensors

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Disease prediction through gene is a challenging task. Researchers have proposed algorithms to identify disease from genes. Traditional algorithms prioritize through annotation and combines the structures in biological process or molecular functions and compared with annotations of known disease genes for classification. Pediatric Cardiomyopathy is a disease due to disorder in heart muscle and identification at early stage is a challenging problem. In this paper, the above problem solves through Window Based Correlation (WBC). In WBC, Global data is reduced to spatial data using block reduction technique. After Data reduction, strong relationship analysis between the genes is identified through RMSE values between the genes. This RMSE values helps to detect the pediatric cardiomyopathy at early stage using Window based correlation method. From the results, ablation study proves an accuracy of prediction is about 85%.

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Historical evolution of cancer genomics research in Latin America: a comprehensive visual and bibliometric analysis until 2023

Lozada-Martinez,

Cabarcas-Martinez

et al. 2024

Front. Genet.

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Background: Cancer genomics, as an interdisciplinary research area within the Global Cancer Research agenda, genomics and precision medicine, its important in research and clinical practice in Latin America. To date, there has been no study investigating evolution of this area in this region. The aim of this study was to evaluate for first time, the historical evolution of cancer genomics research in Latin America.Methods: Bibliometric cross-sectional study of documents on cancer genomics published by Latin American authors until 2023 in Scopus was performed. Statistical and visual analysis was performed with R programming language.Results: A total of 1534 documents were obtained. The first document of cancer genomics research was published in 1997, marking the inception of a 26-year evaluation period that extended until 2023. Among the documents, 74.3% (n = 1140) constituted original articles, followed by 22.7% (n = 349) classified as reviews. International collaboration was observed in 6.5% (n = 100) of the articles. Within the compilation of the ten most prolific authors in this region, 90% of them are from Brazil. This observed pattern extends to affiliations as well, wherein the Universidade de São Paulo emerges as the most active institution (n = 255 documents). This arrangement firmly establishes Brazil’s prominence as the preeminent country in the region concerning cancer genomics research, showcasing robust collaboration networks both regionally and intercontinentally. An important transition in the studied hot topics over the last 20 years was identified, from the exploration of the human genome and the characterization of genomic and proteomic cancer profiles (1997–2010) to an in-depth investigation of cancer stem cells and personalized medicine (2011–2023). Among the array of cancer types under study, predominant attention has been directed towards breast, lung, prostate, and leukemia.Conclusion: Over the course of the past 26 years, a favorable and notable evolution has characterized cancer genomics research within Latin America, with Brazil leading the way, which possess a robust network of regional and intercontinental collaboration. Furthermore, the lines of research and hot topics have change in harmony with the region’s objectives, strategies, and requisites.

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Genomics offers new possibilities for global health through international collaboration

Cited by 3 publications

References 6 publications

The Association of Beliefs About Heredity with Preventive and Interpersonal Behaviors in Communities Affected by Podoconiosis in Rural Ethiopia

The Association of Beliefs About Heredity with Preventive and Interpersonal Behaviors in Communities Affected by Podoconiosis in Rural Ethiopia

Early Detection of Pediatric Cardiomyopathy Disease Using Window Based Correlation Method from Gene Micro Array Data

Historical evolution of cancer genomics research in Latin America: a comprehensive visual and bibliometric analysis until 2023

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