Genomics of Rhodococcus

Cappelletti, Martina; Zampolli, Jessica; Gennaro, Patrizia Di; Zannoni, Davide

doi:10.1007/978-3-030-11461-9_2

Cited by 14 publications

(22 citation statements)

References 153 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed Rhodococcus spp. are known to be extraordinarily diversified in terms of genomic contents, metabolic pathways, and evolutionary adaptations, even when considering strains of the same species (Cappelletti et al 2019b ). In this respect, different Rhodococcus spp.…”

Section: Discussionmentioning

confidence: 99%

“…strains produce biosurfactants in response to the presence of water-insoluble substrates (e.g., hydrocarbons) (Whyte et al 1999 ; Cappelletti et al 2019a ), and in some cases also on water-soluble substances (e.g., ethanol and glucose) (Table 1 ) (Pirog et al 2004 ; Ciapina et al 2006 ). The formation of biosurfactants is believed to improve the utilization (bioavailability) of these water-insoluble compounds as growth substrates by facilitating their entry into cells (Lang and Philp 1998 ; Yakimov et al 1999 ; Philp et al 2002 ; Peng et al 2007 ; Cappelletti et al 2019b ).…”

Section: Biosurfactantsmentioning

confidence: 99%

“…strains, but it is also a source of fatty acids. Further, the alkanes that are incorporated into cellular lipids are not completely degraded to acetyl-CoA (Alvarez 2003 ; Cappelletti et al 2019b ). These studies highlighted the possibility to drive lipid storage to specific branched-chain and odd-numbered fatty acids in R. opacus by only changing the growth substrate, making this species a valuable TAG producer for next-generation biofuels (Tsitko et al 1999 ).…”

Section: Intracellular Accumulation Of Storage Compoundsmentioning

confidence: 99%

“…Rhodococcus genus belongs to the Actinobacteria phylum and comprises genetically and physiologically diverse bacteria, which are distributed in various water, soil, and marine habitats, also including harsh ecological niches such as arctic, desert, and heavily contaminated sites (Cappelletti et al 2019a , 2019b ). The wide distribution of Rhodococcus spp.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Biotechnology of Rhodococcus for the production of valuable compounds

Cappelletti

Presentato

Piacenza

et al. 2020

Appl Microbiol Biotechnol

Self Cite

106

View full text Add to dashboard Cite

Bacteria belonging to Rhodococcus genus represent ideal candidates for microbial biotechnology applications because of their metabolic versatility, ability to degrade a wide range of organic compounds, and resistance to various stress conditions, such as metal toxicity, desiccation, and high concentration of organic solvents. Rhodococcus spp. strains have also peculiar biosynthetic activities that contribute to their strong persistence in harsh and contaminated environments and provide them a competitive advantage over other microorganisms. This review is focused on the metabolic features of Rhodococcus genus and their potential use in biotechnology strategies for the production of compounds with environmental, industrial, and medical relevance such as biosurfactants, bioflocculants, carotenoids, triacylglycerols, polyhydroxyalkanoate, siderophores, antimicrobials, and metal-based nanostructures. These biosynthetic capacities can also be exploited to obtain high value-added products from low-cost substrates (industrial wastes and contaminants), offering the possibility to efficiently recover valuable resources and providing possible waste disposal solutions. Rhodococcus spp. strains have also recently been pointed out as a source of novel bioactive molecules highlighting the need to extend the knowledge on biosynthetic capacities of members of this genus and their potential utilization in the framework of bioeconomy. Key points • Rhodococcus possesses promising biosynthetic and bioconversion capacities. • Rhodococcus bioconversion capacities can provide waste disposal solutions. • Rhodococcus bioproducts have environmental, industrial, and medical relevance.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Biosurfactantsmentioning

confidence: 99%

Section: Intracellular Accumulation Of Storage Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Biotechnology of Rhodococcus for the production of valuable compounds

Cappelletti

Presentato

Piacenza

et al. 2020

Appl Microbiol Biotechnol

Self Cite

106

View full text Add to dashboard Cite

show abstract

“…IBP_PD630 reported the PD630 genome to be composed by one chromosome and nine plasmids (two circular and seven linear plasmids). This result was divergent from the typical number of extrachromosomal elements reported for genomes of this genus, five being the maximum number of extrachromosomal elements described in a single Rhodococcus strain (Cappelletti et al, 2019). Despite the assembly-related issues, IBP_PD630 has been used as reference genome in many works involving -omics analyses for the detection of genetic determinants involved in aromatics tolerance and conversion into lipids (DeLorenzo et al, 2018;Kim et al, 2019;Chen et al, 2013;Yoneda et al, 2016;Henson et al, 2018).…”

Section: Introductionmentioning

confidence: 93%