Genomics of Preterm Birth

Swaggart, Kayleigh A.; Pavličev, Mihaela; Muglia, Louis J.

doi:10.1101/cshperspect.a023127

Cited by 29 publications

(27 citation statements)

References 104 publications

(100 reference statements)

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“…A major reason for this may be the complexity in the etiology of PTB. So far, it is known that this disorder can be linked to conditions as diverse as infection, inflammation, stress, and genetic mutations (5, 6). Moreover, these conditions are often not diagnosed before preterm labor begins.…”

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confidence: 99%

Bitter taste receptors as targets for tocolytics in preterm labor therapy

et al. 2017

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Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity, with few prevention and treatment options. Uterine contraction is a central feature of PTB, so gaining new insights into the mechanisms of this contraction and consequently identifying novel targets for tocolytics are essential for more successful management of PTB. Here we report that myometrial cells from human and mouse express bitter taste receptors (TAS2Rs) and their canonical signaling components ( G-protein gustducin and phospholipase C β2). Bitter tastants can completely relax myometrium precontracted by different uterotonics. In isolated single mouse myometrial cells, a phenotypical bitter tastant (chloroquine, ChQ) reverses the rise in intracellular Ca concentration ([Ca]) and cell shortening induced by uterotonics, and this reversal effect is inhibited by pertussis toxin and by genetic deletion of α-gustducin. In human myometrial cells, knockdown of TAS2R14 but not TAS2R10 inhibits ChQ's reversal effect on an oxytocin-induced rise in [Ca] Finally, ChQ prevents mouse PTBs induced by bacterial endotoxin LPS or progesterone receptor antagonist mifepristone more often than current commonly used tocolytics, and this prevention is largely lost in α-gustducin-knockout mice. Collectively, our results reveal that activation of the canonical TAS2R signaling system in myometrial cells produces profound relaxation of myometrium precontracted by a broad spectrum of contractile agonists, and that targeting TAS2Rs is an attractive approach to developing effective tocolytics for PTB management.-Zheng, K., Lu, P., Delpapa, E., Bellve, K., Deng, R., Condon, J. C., Fogarty, K., Lifshitz, L. M., Simas, T. A. M., Shi, F., ZhuGe, R. Bitter taste receptors as targets for tocolytics in preterm labor therapy.

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Bitter taste receptors as targets for tocolytics in preterm labor therapy

et al. 2017

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“…На сегодняшний день определено большое число факторов, наиболее вероятно способствующих наступлению преждевременных родов при многоплодии. к значимым причинам отнесены перерастяжение матки, несвоевременные структурные изменения шейки матки, инфекционные процессы, приводящие к выбросу каскада воспалительных цитокинов и хемокинов, которые, с одной стороны, приводят к развитию маточных сокращений, с другойк ослаблению плодных оболочек и преждевременному излитию околоплодных вод [12,13].…”

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Challenges and prospects of preterm birth prediction in multiple pregnancies

et al. 2018

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For today, twins make up about 1.5% of the population of our planet. It is more than one hundred million people, which in number corresponds to the population of two Frances. The number of twins born relative to the total number of newborns in different countries and on different continents is different, but the overall trend is that it continues to grow. In recent years, the percentage of multiple pregnancy has increased almost 2.5 times, which is associated with the widespread use of assisted reproductive technologies.At the same time, pregnancy in multiple births is an extremely important problem in modern obstetrics, as it is accompanied by a high level of complications for both the mother and the fetuses. Multiple pregnancy contributes significantly to the formation of adverse perinatal outcomes, which is primarily due to the high rate of preterm birth. Premature twins are at high risk of neurological and neuropsychiatric disorders, respiratory distress, endocrine and metabolic disorders, which subsequently become the cause of disability and social maladaptation of children. In this regard, the reduction in the number of premature births is today a priority task, the solution of which is possible only through timely and correct forecasting. The multifactority of pathogenic mechanisms determines the necessity of diagnostic search strategies that can identify markers of various pathogenetic ways of preterm birth. (For citation: Kosyakova OV, Bespalova ОN. Challenges and prospects of preterm birth prediction in multiple pregnancies. Journal of Obstetrics and Women’s Diseases. 2018;67(4):48-59. doi: 10.17816/JOWD67448-59).

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“…The pathophysiology of PTB is unknown; however, various causes including activation of the maternal/fetal (hypothalamic-pituitary axis), inflammation or infection, decidual hemorrhage, and abnormal uterine distension [7][8][9]. Unexplained spontaneous PTB (SPTB) is the main cause of preterm labor [10]. Nowadays, evidence of genetic factor thought to affect the duration of gestation [11].…”

Section: Introductionmentioning

confidence: 99%

Utility of Placental Leucine Aminopeptidase/Oxytocinase in the Prediction of Preterm Delivery in Pregnant Women With Threatened Preterm Labor

Hassan

Kadir

Mohammed

2019

Asian J Pharm Clin Res

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Objective: The study objective was to assess the utility of placental leucine aminopeptidase (P-LAP) marker for the prediction of delivery in patients presented with threatened preterm labor (TPL). Setting: This study was conducted at the Obstetrics and Gynaecology Department of Al-Yarmouk Teaching Hospital in the period from March 2017 to June 2018. Type of Study: This is a prospective case control study. Methods: This study included 90 pregnant women with gestational age from (28-36+6) weeks; 45 of them who presented with preterm uterine contractions were considered as the study group which was further subdivided into three subgroups according to gestational age 28–31+6 weeks, 32– 33+6 weeks, and 34–36+6 weeks. The other 45 pregnant women who presented to the hospital for regular antenatal care visit at comparable gestational age to the study group were considered as the control group. Hence, this study aimed to assess the serum level of P-LAP in both groups and compare it between those delivered preterm from term to assess its applicability as a predictor of preterm labor. Results: Serum level of P-LAP in pregnant women presented with TPL was found to be significantly lower in those delivered preterm (p<0.001), compared to those continued to term and control group especially in gestational ages ≥32 weeks, while the study found P-LAP level to be statistically insignificant in gestational age <32 weeks (p=0.052). The cutoff point for P-LAP serum level was = 21 (IU/ml) that below it, the pregnant women with TPL most probably deliver before 37 weeks of gestation with Sensitivity (85.7%) Specificity (90.3%), Positive predictive value (80.0%) Negative predictive (93.3%). Conclusion: The serum level of P-LAP was lower in women delivered preterm than those delivered at term, so it can be used as one of the markers for the prediction of preterm delivery, especially at gestational age >32 weeks.

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Genomics of Preterm Birth

Cited by 29 publications

References 104 publications

Bitter taste receptors as targets for tocolytics in preterm labor therapy

Bitter taste receptors as targets for tocolytics in preterm labor therapy

Challenges and prospects of preterm birth prediction in multiple pregnancies

Utility of Placental Leucine Aminopeptidase/Oxytocinase in the Prediction of Preterm Delivery in Pregnant Women With Threatened Preterm Labor

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