Genomics of Performance

Hill, Emmeline W.; Katz, Lisa; MacHugh, David E.

doi:10.1002/9781118522158.ch17

Cited by 1 publication

(2 citation statements)

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“…Horses have been domesticated for working, riding, recreation, sport, and racing, and the development of specific breeds has resulted in the selection of athletic phenotypes [ 21 ]. Exercise and performance are important factors in the selection of horses because the value of the domesticated animal is determined by its abilities to show improved performance [ 16 ]. The Warmblood breed, which has been used for dressage and show jumping, was selected based on its good athletic performance [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Exercise and performance are important factors in the selection of horses because the value of the domesticated animal is determined by its abilities to show improved performance [ 16 ]. The Warmblood breed, which has been used for dressage and show jumping, was selected based on its good athletic performance [ 16 ]. It has generally been accepted that equine genetics and genomics have a critical role in determination of the horse's capabilities [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Integrated analysis of microRNA and mRNA expressions in peripheral blood leukocytes of Warmblood horses before and after exercise

Kim

et al. 2018

J Vet Sci

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Exercise capacity is a valuable trait in horses, and it has been used as a horse selection criterion. Although exercise affects molecular homeostasis and adaptation in horses, the mechanisms underlying these effects are not fully described. This study was carried out to identify changes in the blood profiles of microRNAs (miRNAs) and mRNAs induced by exercise in horse leukocytes. Total RNAs isolated from the peripheral blood leukocytes of four Warmblood horses before and after exercise were subjected to next-generation sequencing (NGS) and microarray analyses to determine the miRNA and mRNA expression profiles, respectively. The expressions of 6 miRNAs, including 4 known and 2 novel miRNAs, were altered by exercise. The predicted target genes of the differentially expressed miRNAs identified by NGS were matched to the exercise-induced mRNAs determined by microarray analysis. Five genes (LOC100050849, LOC100054517, KHDRBS3, LOC100053996, and LOC100062720) from the microarray analysis were matched to the predicted target genes of the 6 miRNAs. The subset of mRNAs and miRNAs affected by exercise in peripheral blood leukocytes may be useful in elucidating the molecular mechanisms of exercise-associated physiology in horses.

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Section: Introductionmentioning

confidence: 99%