Genomics Meets Histamine Receptors: New Subtypes, New Receptors

Hough, Lindsay B.

doi:10.1124/mol.59.3.415

Cited by 292 publications

(232 citation statements)

References 42 publications

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“…It is well recognized that the cellular responses of histamine are mediated through a family of histamine receptors (H 1 , H 2 , H 3 , and H 4 ) variably expressed in different cell types (30). Human endothelial cells predominantly express H 1 R, which are involved in histamine-mediated hypersensitivity reactions and inflammatory responses (9,31).…”

Section: Figurementioning

confidence: 99%

Histamine Directly and Synergistically with Lipopolysaccharide Stimulates Cyclooxygenase-2 Expression and Prostaglandin I2 and E2 Production in Human Coronary Artery Endothelial Cells

Tan

Essengue

Talreja

et al. 2007

The Journal of Immunology

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Although histamine plays an essential role in inflammation, its influence on cyclooxygenases (COX) and prostanoid homeostasis is not well understood. In this study, we investigated the effects of histamine on the expression of COX-1 and COX-2 and determined their contribution to the production of PGE2, prostacyclin (PGI2), and thromboxane A2 in human coronary artery endothelial cells (HCAEC). Incubation of HCAEC monolayers with histamine resulted in marked increases in the expression of COX-2 and production of PGI2 and PGE2 with no significant change in the expression of COX-1. Histamine-induced increases in PGI2 and PGE2 production were due to increased expression and function of COX-2 because gene silencing by small interfering RNA or inhibition of the catalytic activity by a COX-2 inhibitor blocked prostanoid production. The effects of histamine on COX-2 expression and prostanoid production were mediated through H1 receptors. In addition to the direct effect, histamine was found to amplify LPS-stimulated COX-2 expression and PGE2 and PGI2 production. In contrast, histamine did not stimulate thromboxane A2 production in resting or LPS-activated HCAEC. Histamine-induced increases in the production of PGE2 and PGI2 were associated with increased expression of mRNA encoding PGE2 and PGI2 synthases. The physiological role of histamine on the regulation of COX-2 expression in the vasculature is indicated by the findings that the expression of COX-2 mRNA, but not COX-1 mRNA, was markedly reduced in the aortic tissues of histidine decarboxylase null mice. Thus, histamine plays an important role in the regulation of COX-2 expression and prostanoid homeostasis in vascular endothelium.

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Section: Figurementioning

confidence: 99%

Histamine Directly and Synergistically with Lipopolysaccharide Stimulates Cyclooxygenase-2 Expression and Prostaglandin I2 and E2 Production in Human Coronary Artery Endothelial Cells

Tan

Essengue

Talreja

et al. 2007

The Journal of Immunology

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“…These actions are mediated by the activation of specific histamine receptors, namely H 1 , H 2 , H 3 and H 4 . Histamine levels in cells and in tissues are regulated by the activity of histidine decarboxylase (HDC), that is the only enzyme responsible for the generation of histamine from L-histidine [1]. Therefore, HDC can serve as a specific marker for the biosynthesis of histamine.…”

Section: Introductionmentioning

confidence: 99%

Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage

et al. 2005

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“…Functional analyses in these studies were also controversial, describing no effect of the H3R antagonist thioperamide on histamine-induced IL-12p70 suppression (10,13) or suppression of IL-12p70 by the H3R agonist R-␣-methylhistamine (R-␣-MeH) (12). However, the compounds that were used to address the H3R also bind to the H4R and, therefore, do not allow the discrimination of the two receptors (6).…”

Section: Endritic Cells (Dc)mentioning

confidence: 99%

“…Histamine is another factor that is likely to get in contact with DC, e.g., in the skin during hypersensitivity reactions. The effects of histamine are mediated via at least four different G protein-coupled receptors, H1R, H2R, H3R, and H4R (5,6). Recent studies demonstrated the expression of H1R and H2R and effects of histamine on cells of the adaptive immune system, in particular, T cells and DC (7).…”

Section: Endritic Cells (Dc)mentioning

confidence: 99%

Histamine H4 Receptor Stimulation Suppresses IL-12p70 Production and Mediates Chemotaxis in Human Monocyte-Derived Dendritic Cells

Gutzmer

Diestel

Mommert

et al. 2005

The Journal of Immunology

221

249

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There is increasing evidence that histamine as an important mediator of immediate type allergic reactions also effects professional APCs. Recent reports showed effects of histamine on human monocyte-derived dendritic cells (MoDC) mediated primarily via histamine H1 receptors (H1R) and H2R. We show here that MoDC also express H3R and H4R at the mRNA and protein level. mRNA of the H3R is down-regulated and mRNA of the H4R is up-regulated during the differentiation from monocytes to MoDC. H4R or H2R stimulation suppressed IL-12p70 production in MoDC. Induction of cAMP was necessary for IL-12p70 inhibition mediated via the H2R. In contrast, H4R stimulation did not affect cAMP production but induced the transcription factor AP-1, and U0126, an inhibitor of AP-1 transactivation and MEK, rescued H4R mediated IL-12p70 suppression. Moreover, MoDC responded to a H4R agonist (and also to a H2R agonist) with increased F-actin polymerization and migration in modified Boyden chamber assays, suggesting a chemotactic effect of histamine via the H2R and the H4R. Thus, H4R stimulation on MoDC results in immunomodulatory and chemotactic effects. Histamine induces chemotaxis and IL-12p70 suppression via different receptors using different signaling pathways, which might be important for the pathogenesis of and therapeutic interventions in allergic diseases.

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Genomics Meets Histamine Receptors: New Subtypes, New Receptors

Cited by 292 publications

References 42 publications

Histamine Directly and Synergistically with Lipopolysaccharide Stimulates Cyclooxygenase-2 Expression and Prostaglandin I2 and E2 Production in Human Coronary Artery Endothelial Cells

Histamine Directly and Synergistically with Lipopolysaccharide Stimulates Cyclooxygenase-2 Expression and Prostaglandin I2 and E2 Production in Human Coronary Artery Endothelial Cells

Histamine and histidine decarboxylase up-regulation in colorectal cancer: correlation with tumor stage

Histamine H4 Receptor Stimulation Suppresses IL-12p70 Production and Mediates Chemotaxis in Human Monocyte-Derived Dendritic Cells

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