Genomics‐based re‐examination of the taxonomy and phylogeny of <i>human</i> and <i>simian Mastadenoviruses</i>: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis

Kang, June; Ismail, Ashrafali Mohamed; Dehghan, Shoaleh; Rajaiya, Jaya; Allard, Marc W.; Lim, Haw Chuan; Dyer, David W.; Chodosh, James; Seto, Donald

doi:10.1111/cla.12422

Cited by 14 publications

(15 citation statements)

References 79 publications

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“…These analyses, combined with their distinct genome sizes, and the differences in nucleotide composition warrant the human AdVs, the gorilla AdVs, and the combined group of bonobo and chimpanzee AdVs to be considered as clades of different taxa. These data confirm and extend the results of Kang and collaborators who used full genome sequence analyses of a large set of human and simian adenoviruses to provide a proposal for a more consistent and revised taxonomy for the primate adenoviruses [ 32 ]. Based on the observation that many of the clades encompass AdV isolates from humans as well as from non-human primates, they propose the designation of all AdVs isolated from humans and from non-human primates as ‘primate adenoviruses’ (PrAdV).…”

Section: Discussionsupporting

confidence: 85%

“…This clade includes all AdVs isolated from humans and from simians. The human-, gorilla-, chimpanzee-, and bonobo-derived AdVs that are conventionally grouped in the HAdV-C species are proposed to be reclassified as three distinct species: PrAdV-C (the human-derived HAdV-C types such as C1, C2, C5, C6, and C57), PrAdV-K (gorilla-derived isolates as SAdV-43 and SAdV45), and PrAdV-S (bonobo- and chimpanzee-derived isolates such as SAdV-34 and SAdV-44) [ 32 ]. This PrAdV classification is fully supported by the analyses of the HAdV-C isolates presented in our study.…”

Section: Discussionmentioning

confidence: 99%

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Genome Analyses of Ten New Ape Adenoviruses with Similarity to Human Mastadenovirus C

Bots

Kemp

Dautzenberg

et al. 2022

IJMS

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The adenoviruses (AdVs) isolated from humans are taxonomically grouped in seven different species in the Mastadenovirus genus (HAdV-A through G). AdVs isolated from apes are often included in one of the human AdV species. Here we describe the sequence analyses of ten new AdVs that are related to the HAdV-C species and that were isolated from healthy western lowland gorillas, bonobos, chimpanzees, and orangutans kept in Dutch zoos. We analyzed these viruses and compared their genome sequences to those of human- and ape-derived AdV sequences in the NCBI GenBank database. Our data demonstrated that the ape-derived viruses clustering to HAdV-C are markedly distinct from the human HAdV-C species in the size and nucleotide composition (%GC) of their genome, differ in the amino-acid sequence of AdV proteins, and have longer RGD-loops in their penton-base proteins. The viruses form three well-separated clades (the human, the gorilla, and the combined group of the bonobo and chimpanzee viruses), and we propose that these should each be given species-level ranks. The Ad-lumc005 AdV isolated from orangutans was found to be very similar to the gorilla AdVs, and bootstrap inference provided evidence of recombination between the orangutan AdV and the gorilla AdVs. This suggests that this virus may not be a genuine orangutan AdV but may have been transferred from a gorilla to an orangutan host.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Genome Analyses of Ten New Ape Adenoviruses with Similarity to Human Mastadenovirus C

Bots

Kemp

Dautzenberg

et al. 2022

IJMS

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“…Ads are non-enveloped doublestranded DNA viruses most commonly responsible for mild selflimiting respiratory and ocular infections in humans 27 . Over 150 primate Ads have been characterized, with many Ads in development for vaccine purposes 28,29 . Like mRNA vaccines, Ad vaccines are a relatively new technology, although Ads have been used as gene delivery vehicles since the earliest days of gene therapy.…”

Section: Adenoviral Vector Vaccinesmentioning

confidence: 99%

Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic

et al. 2021

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Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases, and their ability to induce a potent and balanced immune response made them logical candidates to apply to the COVID-19 pandemic. The unique molecular characteristics of these vectors enabled the rapid development of vaccines with advanced designs capable of overcoming the biological challenges faced by early adenoviral vector systems. These successes and the urgency of the COVID-19 situation have resulted in a flurry of candidate adenoviral vector vaccines for COVID-19 from both academia and industry. These vaccines represent some of the lead candidates currently supported by Operation Warp Speed and other government agencies for rapid translational development. This review details adenoviral vector COVID-19 vaccines currently in human clinical trials and provides an overview of the new technologies employed in their design. As these vaccines have formed a cornerstone of the COVID-19 global vaccination campaign, this review provides a full consideration of the impact and development of this emerging platform.

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“…We reported SAdV-F-like AdVs for the first time in freeroaming NHPs and after ~six decades from captive NHPs. The detection of SAdV-Flike AdVs and SAdV-F/SAdV-17/18 in related host species (AGMs and grivet monkeys, respectively, genus Chlorocebus) mirrored the hypothesis that AdVs have a narrow host range [1][2][3][4]14,15,17]. SAdV-F/SADV-17 and -18 were detected in the intestinal contents of grivet monkeys [47], whilst the SAdV-F-like AdVs from AGMs were identified in both fecal/rectal and nasal samples.…”

Section: Discussionmentioning

confidence: 93%

“…On the other ha the origin of KNA-S6 appear to be complex, with a SAdV-F/SAdV-18-like Pol, and a he and a penton base that was more closely related to HAdV-F/HAdV-40(HAdV-F/HA 40-like) and SAdV-F/SAdV-17, respectively. The AdV hexon has been proposed to b active site for recombination events [3,[14][15][16][17][18]. Although recombination analysis should performed on complete genomes of AdVs [17], we a empted to evaluate the comp hexon coding sequence of KNA-S6 (and KNA-08975) for possible recombination eve However, inconclusive results were obtained with the RDP4 program.…”

Section: Putativementioning

confidence: 99%

Detection and Molecular Characterization of Adenoviruses in Captive and Free-Roaming African Green Monkeys (Chlorocebus sabaeus): Evidence for Possible Recombination and Cross-Species Transmission

Mancuso

Gainor

Dore

et al. 2023

Viruses

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In the present study, 31 samples (12 fecal, 9 nasal and 10 rectal swabs) from 28/92 (30.43%, 10 captive and 18 free-roaming African green monkeys (AGMs, Chlorocebus sabaeus)) apparently healthy AGMs in the Caribbean Island of St. Kitts tested positive for adenoviruses (AdVs) by DNA-dependent DNA polymerase (pol)-, or hexon-based screening PCR assays. Based on analysis of partial deduced amino acid sequences of Pol- and hexon- of nine AGM AdVs, at least two AdV genetic variants (group-I: seven AdVs with a Simian mastadenovirus-F (SAdV-F)/SAdV-18-like Pol and hexon, and group-II: two AdVs with a SAdV-F/SAdV-18-like Pol and a Human mastadenovirus-F (HAdV-F)/HAdV-40-like hexon) were identified, which was corroborated by analysis of the nearly complete putative Pol, complete hexon, and partial penton base sequences of a representative group-I (strain KNA-08975), and -II (KNA-S6) AdV. SAdV-F-like AdVs were reported for the first time in free-roaming non-human primates (NHPs) and after ~six decades from captive NHPs. Molecular characterization of KNA-S6 (and the other group-II AdV) indicated possible recombination and cross-species transmission events involving SAdV-F-like and HAdV-F-like viruses, corroborating the hypothesis that the evolutionary pathways of HAdVs and SAdVs are intermingled, complicated by recombination and inter-species transmission events, especially between related AdV species, such as HAdV-F and SAdV-F. To our knowledge, this is the first report on detection and molecular characterization of AdVs in AGMs.

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Genomics‐based re‐examination of the taxonomy and phylogeny of human and simian Mastadenoviruses: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis

Cited by 14 publications

References 79 publications

Genome Analyses of Ten New Ape Adenoviruses with Similarity to Human Mastadenovirus C

Genome Analyses of Ten New Ape Adenoviruses with Similarity to Human Mastadenovirus C

Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic

Detection and Molecular Characterization of Adenoviruses in Captive and Free-Roaming African Green Monkeys (Chlorocebus sabaeus): Evidence for Possible Recombination and Cross-Species Transmission

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