2010
DOI: 10.5115/acb.2010.43.1.1
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Genomics and proteomics in stem cell research: the road ahead

Abstract: Stem cell research has been widely studied over the last few years and has attracted increasing attention from researchers in all fields of medicine due to its potential to treat many previously incurable diseases by replacing damaged cells or tissues. As illustrated by hematopoietic stem research, understanding stem cell differentiation at molecular levels is essential for both basic research and for clinical applications of stem cells. Although multiple integrative analyses, such as genomics, epigenomics, tr… Show more

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Cited by 13 publications
(5 citation statements)
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References 124 publications
(139 reference statements)
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“…Embryonic and non-embryonic stem cells have been considered as potential therapeutic approaches for several types of diseases. One type of adult stem cell, the mesenchymal stem cell (MSC), has attracted a great deal of attention in the field of regenerative medicine due to its unique biological properties [1]. Bone marrow-derived MSCs (BMSCs) were first identified in 1968 by Friedenstein as an adherent fibroblast-like cell in the bone marrow that was capable of differentiating into bone [2].…”
Section: Introductionmentioning
confidence: 99%
“…Embryonic and non-embryonic stem cells have been considered as potential therapeutic approaches for several types of diseases. One type of adult stem cell, the mesenchymal stem cell (MSC), has attracted a great deal of attention in the field of regenerative medicine due to its unique biological properties [1]. Bone marrow-derived MSCs (BMSCs) were first identified in 1968 by Friedenstein as an adherent fibroblast-like cell in the bone marrow that was capable of differentiating into bone [2].…”
Section: Introductionmentioning
confidence: 99%
“…Human embryonic stem cells (hESCs) provide valuable insight into human development and disease, have exciting potential in regenerative medicine, and can be used as models for drug discovery and toxicity analyses (reviewed in 1). These cells are derived from the inner cell mass of a pre‐implantation embryo, called the blastocyst 2.…”
Section: Introductionmentioning
confidence: 99%
“…Increasing attention is paid to enrich and characterize membrane and plasma‐membrane proteins of PSCs in search of surface markers that can define stem cells, and their developmental stages . Previous success on identifying the “cluster of differentiation” (CD) markers in leukocytes coming out of the Human Leukocyte Differentiation Antigens Workshop (HLDA) encouraged the surface proteomics of PSCs. Many techniques have been explored to characterize membrane proteomes of PSCs as summarized in a few reviews in 2008 .…”
Section: Functional Importance Of Cell Surface Proteinsmentioning
confidence: 99%