Genomics and Proteomics for Clinical Discovery and Development

Abstract

Aims and ScopeThe Book Series in Translational Bioinformatics is a powerful and integrative resource for understanding and translating discoveries and advances of genomic, transcriptomic, proteomic and bioinformatic technologies into the study of human diseases. The Series represents leading global opinions on the translation of bioinformatics sciences into both the clinical setting and descriptions to medical informatics. It presents the critical evidence to further understand the molecular mechanisms underlying organ or cell dysfunctions in human diseases, the results of genomic, transcriptomic, proteomic and bioinformatic studies from human tissues dedicated to the discovery and validation of diagnostic and prognostic disease biomarkers, essential information on the identifi cation and validation of novel drug targets and the application of tissue genomics, transcriptomics, proteomics and bioinformatics in drug effi cacy and toxicity in clinical research.The Book Series in Translational Bioinformatics focuses on outstanding articles/chapters presenting signifi cant recent works in genomic, transcriptomic, proteomic and bioinformatic profi les related to human organ or cell dysfunctions and clinical fi ndings. The Series includes bioinformatics-driven molecular and cellular disease mechanisms, the understanding of human diseases and the improvement of patient prognoses. Additionally, it provides practical and useful study insights into and protocols of design and methodology. Series DescriptionTranslational bioinformatics is defi ned as the development of storage-related, analytic, and interpretive methods to optimize the transformation of increasingly voluminous biomedical data, and genomic data in particular, into proactive, predictive, preventive, and participatory health. Translational bioinformatics includes research on the development of novel techniques for the integration of biological and clinical data and the evolution of clinical informatics methodology to encompass biological observations. The end product of translational bioinformatics is the newly found knowledge from these integrative efforts that can be disseminated to a variety of stakeholders including biomedical scientists, clinicians, and patients. Issues related to database management, administration, or policy will be coordinated through the clinical research informatics domain. Analytic, storage-related, and interpretive methods should be used to improve predictions, early diagnostics, severity monitoring, therapeutic effects, and the prognosis of human diseases. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this...