Genomic Variation of the Fibropapilloma-Associated Marine Turtle Herpesvirus across Seven Geographic Areas and Three Host Species

Greenblatt, Rebecca J.; Quackenbush, Sandra L.; Casey, Rufina N.; Rovnak, Joel; Balazs, George H.; Work, Thierry M.; Casey, James W.; Sutton, C. A.

doi:10.1128/jvi.79.2.1125-1132.2005

Cited by 70 publications

(90 citation statements)

References 36 publications

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“…Sea turtles undergo an oceanic stage during the first few years of their lives, while as juveniles they recruit to coastal foraging habitats where they remain for several years. Mature individuals move periodically from neritic bays to nesting beaches and mating areas, Our results support the conclusion that horizontal transmission in neritic bays is the major route by which individuals become infected, which is further supported by the demonstration that infectious CFPHV particles are transmitted along with FP through skin lesions (Herbst et al, 1995(Herbst et al, , 1996.Our phylogeny differed from a previous analysis by Greenblatt et al (2005). First, the Puerto Rican haplotypes were efficiently placed in the phylogeny of CFPHV.…”

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confidence: 56%

“…Chelonid fibropapilloma-associated herpesvirus (CFPHV) is the most likely aetiological agent of fibropapillomatosis (FP) (Arthur et al, 2008a;Greenblatt et al, 2005;Lackovich et al, 1999;Quackenbush et al, 1998), a neoplastic disease of sea turtles, characterized by recent outbreaks (Diez et al, 2010;Foley et al, 2005;Work & Balazs, 1999). The tumours can be both external and internal and, although benign, depending on location and size, they may obstruct crucial functions such as swimming, feeding and sight, or may impede organ function (Herbst, 1994;Herbst & Klein, 1995).…”

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confidence: 99%

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Global phylogeography and evolution of chelonid fibropapilloma-associated herpesvirus

Patrício

Herbst

Duarte

et al. 2012

Journal of General Virology

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6Lisbon Oceanarium, 1999-005 Lisbon, Portugal A global phylogeny for chelonid fibropapilloma-associated herpesvirus (CFPHV), the most likely aetiological agent of fibropapillomatosis (FP) in sea turtles, was inferred, using dated sequences, through Bayesian Markov chain Monte Carlo analysis and used to estimate the virus evolutionary rate independent of the evolution of the host, and to resolve the phylogenetic positions of new haplotypes from Puerto Rico and the Gulf of Guinea. Four phylogeographical groups were identified: eastern Pacific, western Atlantic/eastern Caribbean, mid-west Pacific and Atlantic. The latter comprises the Gulf of Guinea and Puerto Rico, suggesting recent virus gene flow between these two regions. One virus haplotype from Florida remained elusive, representing either an independent lineage sharing a common ancestor with all other identified virus variants or an Atlantic representative of the lineage giving rise to the eastern Pacific group. The virus evolutionary rate ranged from 1.62¾10 "4 to 2.22¾10 "4 substitutions per site per year, which is much faster than what is expected for a herpesvirus. The mean time for the most recent common ancestor of the modern virus variants was estimated at 192.90-429.71 years ago, which, although more recent than previous estimates, still supports an interpretation that the global FP pandemic is not the result of a recent acquisition of a virulence mutation(s). The phylogeographical pattern obtained seems partially to reflect sea turtle movements, whereas altered environments appear to be implicated in current FP outbreaks and in the modern evolutionary history of CFPHV. INTRODUCTIONChelonid fibropapilloma-associated herpesvirus (CFPHV) is the most likely aetiological agent of fibropapillomatosis (FP) (Arthur et al., 2008a;Greenblatt et al., 2005;Lackovich et al., 1999;Quackenbush et al., 1998), a neoplastic disease of sea turtles, characterized by recent outbreaks (Diez et al., 2010;Foley et al., 2005;Work & Balazs, 1999). The tumours can be both external and internal and, although benign, depending on location and size, they may obstruct crucial functions such as swimming, feeding and sight, or may impede organ function (Herbst, 1994;Herbst & Klein, 1995). Severe FP also leads to bacteraemia (Work et al., 2003). The most susceptible life stages appear to be neritic juveniles and subadults, whereas in adults the disease is rare (Ene et al., 2005;Herbst & Klein, 1995;Work et al., 2004). A high prevalence of FP is common in anthropogenically altered environments (Aguirre & Lutz, 2004;Herbst, 1994;Van Houtan et al., 2010), suggesting that factors in these environments promote disease outbreaks, for example, through the enhancement of virus transmissibility and/or the enhancement of disease expression via substances thatThe GenBank/EMBL/DDBJ accession numbers for the CFPHV sequences determined in this study are JN580279-JN580296 and JN625251-JN625262.Further details about samples are available with the online version of this paper. Phylogenies of herpesv...

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confidence: 56%

Section: Introductionmentioning

confidence: 99%

Global phylogeography and evolution of chelonid fibropapilloma-associated herpesvirus

Patrício

Herbst

Duarte

et al. 2012

Journal of General Virology

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“…An emerging worldwide threat to green turtles is fibropapillomatosis (Herbst, 1994), which is a pandemic disease associated with the presence of herpesviruses (Greenblatt et al, 2005).…”

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confidence: 99%

“…1A). Fibropapillomatosis prevalence has apparently increased over the past 2-3 decades in green turtle populations in Australia, Indonesia, and the US (Herbst, 1994;Chaloupka and Balazs, 2005;Foley et al, 2005;Greenblatt et al, 2005). It is believed that FP might impair recovery of depleted populations (Herbst, 1994;Ene et al, 2005), especially the green turtle stock endemic to Hawaii (Balazs and Chaloupka, 2004;Chaloupka and Balazs, 2005).…”

mentioning

confidence: 99%

“…Fibropapillomatosis is a major cause of stranding in Hawaiian green turtles (Chaloupka et al, 2008b) and is associated with an alphaherpesvirus, but the role of this virus in disease causation remains unknown (Quackenbush et al, 2001;Lackovich et al, 1999;Greenblatt et al, 2005). Interestingly, FP in Hawaiian green turtles was known long before the Palaau outbreak but was rare (Herbst, 1994).…”

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confidence: 99%

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Rise and Fall over 26 Years of a Marine Epizootic in Hawaiian Green Sea Turtles

Chaloupka

Balazs

Work

2009

Journal of Wildlife Diseases

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Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses

Sjodin,

Willig,

Rodríguez‐Durán

et al. 2024

Ecology and Evolution

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Public health concerns about recent viral epidemics have motivated researchers to seek novel ways to understand pathogen infection in native, wildlife hosts. With its deep history of tools and perspectives for understanding the abundance and distribution of organisms, ecology can shed new light on viral infection dynamics. However, datasets allowing deep explorations of viral communities from an ecological perspective are lacking. We sampled 1086 bats from two, adjacent Puerto Rican caves and tested them for infection by herpesviruses, resulting in 3131 short, viral sequences. Using percent identity of nucleotides and a machine learning algorithm (affinity propagation), we categorized herpesviruses into 43 operational taxonomic units (OTUs) to be used in place of species in subsequent ecological analyses. Herpesvirus metacommunities demonstrated long‐tailed rank frequency distributions at all analyzed levels of host organization (i.e., individual, population, and community). Although 13 herpesvirus OTUs were detected in more than one host species, OTUs generally exhibited host specificity by infecting a single core host species at a significantly higher prevalence than in all satellite species combined. We describe the natural history of herpesvirus metacommunities in Puerto Rican bats and suggest that viruses follow the general law that communities comprise few common and many rare species. To guide future efforts in the field of viral ecology, hypotheses are presented regarding mechanisms that contribute to these patterns.

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Genomic Variation of the Fibropapilloma-Associated Marine Turtle Herpesvirus across Seven Geographic Areas and Three Host Species

Cited by 70 publications

References 36 publications

Global phylogeography and evolution of chelonid fibropapilloma-associated herpesvirus

Global phylogeography and evolution of chelonid fibropapilloma-associated herpesvirus

Rise and Fall over 26 Years of a Marine Epizootic in Hawaiian Green Sea Turtles

Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses

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