Genomic Sequence Analysis of the MHC Class I G/F Segment in Common Marmoset (<i>Callithrix jacchus</i>)

Kono, Azumi; Brameier, Markus; Roos, Christian; Suzuki, Shingo; Shigenari, Atsuko; Kametani, Yoshie; Kitaura, Kazutaka; Matsutani, Takaji; Suzuki, Ryuji; Inoko, Hidetoshi; Walter, Lutz; Shiina, Takashi

doi:10.4049/jimmunol.1302745

Cited by 22 publications

(26 citation statements)

References 27 publications

(29 reference statements)

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“…The MHC‐I alleles identified from marmosets in this study were clustered with the HLA/Patr‐G group, but the relationship was limited as shown in the phylogenetic tree (Figure ). Studies of MHC‐B/C and MHC‐G/F segments by genomic sequencing in common marmosets were described previously . In our study, novel MHC‐I alleles with full‐length sequences encoding whole proteins were identified as Caja‐G, which indicated that Caja‐G locus was predominant in the lymphocytes of those marmosets.…”

Section: Mhc Class I Alleles Detected In 12 Common Marmosetssupporting

confidence: 54%

Characterization of major histocompatibility complex class I allele polymorphisms in common marmosets

Yin

et al. 2014

Tissue Antigens

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Currently, little information is available for major histocompatibility complex (MHC)-I that conditions the T-cell response of marmosets. In this study, 471 clones of MHC-I cDNA sequences were isolated from 12 marmosets. Twenty full-length sequences of class I G (Caja-G) alleles were obtained from these marmosets, 15 of them were novel. Among these 20 Caja-G alleles, 10 were found in individual animals while the rests were in two to four marmosets, but none was common to all animals. Ten marmosets possessed one to three Caja-G alleles, and two marmosets carried five or six alleles, which suggested that the Caja-G locus was duplicated in marmoset's genome. The high polymorphisms of Caja-G sequences provided important information helpful for understanding the cellular immune response in virus-infected marmosets.

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Section: Mhc Class I Alleles Detected In 12 Common Marmosetssupporting

confidence: 54%

Characterization of major histocompatibility complex class I allele polymorphisms in common marmosets

Yin

et al. 2014

Tissue Antigens

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“…2a). The MHC-A region was probably formed by birth and death evolution (Piontkivska and Nei 2003) such as by repeated gene duplication and deletion events in human and non-human primates (Kono et al 2014;Shiina et al 2006) as shown in the detailed segmental and phylogenetic sequence analysis of the rhesus macaque MHC alpha block ). In the HLA-A region, an approximately 70 kb insertion and 50 kb deletion near the HLA-A gene were detected in some HLA-A allele lineages (Watanabe et al 1997).…”

Section: Discussionmentioning

confidence: 97%

Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing

et al. 2015

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Although the low polymorphism of the major histocompatibility complex (MHC) transplantation genes in the Filipino cynomolgus macaque (Macaca fascicularis) is expected to have important implications in the selection and breeding of animals for medical research, detailed polymorphism information is still lacking for many of the duplicated class I genes. To better elucidate the degree and types of MHC polymorphisms and haplotypes in the Filipino macaque population, we genotyped 127 unrelated animals by the Sanger sequencing method and high-resolution pyrosequencing and identified 112 different alleles, 28 at cynomolgus macaque MHC (Mafa)-A, 54 at Mafa-B, 12 at Mafa-I, 11 at Mafa-E, and seven at Mafa-F alleles, of which 56 were newly described. Of them, the newly discovered Mafa-A8*01:01 lineage allele had low nucleotide similarities (<86%) with primate MHC class I genes, and it was also conserved in the Vietnamese and Indonesian populations. In addition, haplotype estimations revealed 17 Mafa-A, 23 Mafa-B, and 12 Mafa-E haplotypes integrated with 84 Mafa-class I haplotypes and Mafa-F alleles. Of these, the two Mafa-class I haplotypes, F/A/E/B-Hp1 and F/A/E/B-Hp2, had the highest haplotype frequencies at 10.6 and 10.2%, respectively. This suggests that large scale genetic screening of the Filipino macaque population would identify these and other high-frequency Mafa-class I haplotypes that could be used as MHC control animals for the benefit of biomedical research.

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“…In addition, two large segments of the marmoset MHC class I region have been sequenced. The G/F segment corresponds to the part of the HLA complex containing the HLA‐A , HLA‐F , and HLA ‐ G genes and has 14 genes related to HLA‐G and five related to HLA‐F , but none corresponding to HLA‐A . The B/C segment corresponds to the part of the HLA complex containing the HLA‐B and ‐C genes and contains nine Caja‐B genes, five of which appear functional .…”

Section: Kir Genes Of Catarrhine and Platyrrhine Primates Are More DImentioning

confidence: 99%

Co‐evolution of MHC class I and variable NK cell receptors in placental mammals

Guethlein

Norman

Hilton

et al. 2015

Immunological Reviews

140

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Summary Shaping natural killer (NK) cell functions in human immunity and reproduction are diverse killer-cell immunoglobulin-like receptors (KIRs) that recognize polymorphic MHC class I determinants. A survey of placental mammals suggests KIRs serve as variable NK cell receptors only in certain primates and artiodactyls. Divergence of functional and variable KIRs in primates and artiodactyls predates placental reproduction. Among artiodactyls, cattle but not pigs have diverse KIRs. Catarrhine (humans, apes, and Old World monkeys) and platyrrhine (New World monkeys) primates, but not prosimians, have diverse KIRs. Platyrrhine and catarrhine systems of KIR and MHC class I are highly diverged, but within the catarrhines a stepwise co-evolution of MHC class I and KIRs is discerned. In Old World monkeys, diversification focuses on MHC-A and MHC-B and their cognate lineage II KIR. With evolution of C1-bearing MHC-C from MHC-B, as informed by orangutan, the focus changes to MHC-C and its cognate lineage III KIR. Evolution of C2 from C1 and fixation of MHC-C, drove further elaboration of MHC-C-specific KIRs, as exemplified by chimpanzee. In humans, the evolutionary trajectory changes again. Emerging from reorganization of the KIR locus and selective attenuation of KIR avidity for MHC class I are the functionally distinctive KIR A and KIR B haplotypes.

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Genomic Sequence Analysis of the MHC Class I G/F Segment in Common Marmoset (Callithrix jacchus)

Cited by 22 publications

References 27 publications

Characterization of major histocompatibility complex class I allele polymorphisms in common marmosets

Characterization of major histocompatibility complex class I allele polymorphisms in common marmosets

Discovery of novel MHC-class I alleles and haplotypes in Filipino cynomolgus macaques (Macaca fascicularis) by pyrosequencing and Sanger sequencing

Co‐evolution of MHC class I and variable NK cell receptors in placental mammals

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