Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE

Chagnon, Yvon C.; Rice, Treva; Pérusse, Louis; Borecki, Ingrid B.; Ho-Kim, My Anh; Lacaille, Michel; Paré, Claude; Bouchard, Luigi; Gagnon, Jacques; Leon, Arthur S.; Skinner, James S.; Wilmore, Jack H.; Rao, D. C.; Bouchard, Claude

doi:10.1152/jappl.2001.90.5.1777

Cited by 100 publications

(71 citation statements)

References 27 publications

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“…The findings of linkage on chromosomes 1, 5, 12 and 18 in this study are consistent Genome scan linkage for longitudinal burden of BMI W Chen et al with the HERITAGE Family Study in respect to changes in obesity traits including BMI after a 20-week enduranceexercise training program. 31 The genetic regions with positive linkage on chromosomes 1, 5, 12 and 18 found in this study have confirmed the findings on these four chromosomes from the HERITAGE Family Study. 31 Further, a number of obesity-related candidate genes are located in the regions or near the markers showing positive linkage in this study, as summarized in Table 4.…”

Section: Discussionsupporting

confidence: 88%

“…31 The genetic regions with positive linkage on chromosomes 1, 5, 12 and 18 found in this study have confirmed the findings on these four chromosomes from the HERITAGE Family Study. 31 Further, a number of obesity-related candidate genes are located in the regions or near the markers showing positive linkage in this study, as summarized in Table 4. Of interest, in the present study, the strongest linkage evidence for both total AUC and incremental AUC was found in the same position (110 cM) on chromosome 12q24.1 at the marker D12PAH, covering a region of 22 cM.…”

Section: Discussionsupporting

confidence: 88%

“…Of interest, in the present study, the strongest linkage evidence for both total AUC and incremental AUC was found in the same position (110 cM) on chromosome 12q24.1 at the marker D12PAH, covering a region of 22 cM. Important candidate genes in this region include IGF-1 31,32 and SR-BI, 33 which showed positive linkage and association with obesity measures in previous studies. IGF-1 gene is localized at 12q23.2, about 3 cM from D12PAH.…”

Section: Discussionsupporting

confidence: 55%

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An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study

Chen

Cook

et al. 2004

Int J Obes

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OBJECTIVE:To examine genetic loci linked to a long-term burden and trend of obesity traits, such as body mass index (BMI), from childhood to adulthood. DESIGN: Longitudinal study using serial measurements of BMI from childhood. SUBJECTS: A total of 782 unselected white siblings (representing 521 full and 39 half sib-pairs) from 342 families enrolled in the Bogalusa Heart Study. MEASUREMENTS: A total of 357 microsatellite markers with an average spacing of 9.0 cM spanning the 22 autosomal chromosomes were typed. A quadratic growth curve was developed using a random effects model based on serial measurements of BMI from childhood to adulthood. The serial changes in BMI were measured in terms of long-term burden (area under the curve (AUC) divided by follow-up years) and the long-term trend (incremental AUC, calculated as total AUCÀbaseline AUC). RESULTS: Heritability estimates of long-term measures were 0.78 for total AUC and 0.43 for incremental AUC. In a variancecomponent-based multipoint linkage analysis with SOLAR, linkage to the long-term measures of BMI was observed on chromosomes 1, 5, 7, 12, 13 and 18. For total AUC, LOD scores were 3.0 at 110 cM on chromosome 12, 2.9 at 26 cM and 2.4 at 52 cM on chromosome 7, and 2.2 at 126 cM on chromosome 5. For incremental AUC, LOD scores were 2.9 at 26 cM, 2.1 at 97 cM and 2.3 at 110 cM on chromosome 12, 2.2 at 69 cM on chromosome 7, 2.2 at 91 cM and 2.5 at 150 cM on chromosome 1, 2.0 at 119 cM on chromosome 5, 2.0 at 54 cM on chromosome 13 and 2.0 at 7 cM on chromosome 18. Several important obesity-related candidate genes are located in the regions or near the markers showing positive linkage. CONCLUSION: Linkage evidence found in this study indicates that regions on these chromosomes might harbor genetic loci that affect the propensity to develop obesity from childhood.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 55%

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An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study

Chen

Cook

et al. 2004

Int J Obes

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“…Genetic variation in the RETN has been found in association with obesity (Engert et al, 2002) and type 2 diabetes (Ma et al, 2002;Wang et al, 2002). Obesity and diabetes related phenotypes, such as sum of skinfolds, leptin levels and percentage body fat, have been linked to this region on chromosome 19 (Chagnon et al, 2001). The functional variant responsible for the resistin cis-eQTL identified in our study remains to be elucidated.…”

Section: Discussionmentioning

confidence: 70%

Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

et al. 2008

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“…In humans, loss-of-function mutations in PCSK1 cause monogenic obesity, impaired glucose tolerance and other related disorders. [4][5][6] In both genome-wide linkage studies [7][8][9][10] and candidate gene strategy studies, 11 single-nucleotide polymorphisms (SNPs) in the PCSK1 gene were associated with obesity. Most of these studies focused on the SNPs rs6232 and rs6235.…”

Section: Introductionmentioning

confidence: 99%

The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population

Ling

et al. 2012

Hypertens Res

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Proprotein convertase subtilisin/kexin-type 1 (PCSK1) is a prohormone convertase that has an important role in prohormone maturation including the process of prorenin to renin. We studied the association of the PCSK1 single-nucleotide polymorphism (SNP) rs6235 (encoding an S690T substitution) with essential hypertension (EH), obesity and related traits in the Han Chinese population. The rs6235 SNP in the PCSK1 gene was investigated using a case-control study design, with 1034 hypertension cases and 1112 normotensive controls. In this study, the rs6235 SNP was significantly associated with hypertension (OR ¼ 1.26, 95% CI (1.10-1.46), P ¼ 0.001); the odds ratios of GC vs GG and CC vs GG were 1.30 (95% CI (1.06-1.58), P ¼ 0.010) and 1.55 (95% CI (1.12-2.13), P ¼ 0.007), respectively. In the controls, the C-allele was associated with increased systolic (P ¼ 0.010) and diastolic (P ¼ 0.010) blood pressure levels. In all of the EH patients and EH patients without a history of renin-angiotensin-aldosterone (RAA) system-related antagonists, the C-allele was associated with increased plasma renin activity (P ¼ 0.00004 and 0.002, respectively) and aldosterone levels (P ¼ 0.018 and 0.005, respectively). The C-allele was also associated with increased body mass index (BMI) (P ¼ 0.010) in the normotensive controls. In conclusion, the PCSK1 SNP rs6235 was associated with EH and blood pressure in the Han Chinese population, and this association may be mediated by the SNP's effect on RAA levels. rs6235 was also associated with BMI in this population.

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Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE

Cited by 100 publications

References 27 publications

An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study

An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study

Cross-species replication of a resistin mRNA QTL, but not QTLs for circulating levels of resistin, in human and baboon

The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population

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