“…A celiac disease PRS improves upon HLA typing alone [17][18][19] , and pilot clinical studies indicate improved effectiveness and cost-efficiency for celiac diagnosis, potentially reducing invasive diagnostic procedures 20 . For juvenile idiopathic arthritis and its subtypes, PRS may substantially improve upon clinical diagnosis, potentially reducing long waiting periods for diagnosis and treatment 21 . Furthermore, a PRS for ankylosing spondylitis has been shown to have high diagnostic capacity (AUROCs of 0.92 and 0.94 in European and East Asian ancestries, respectively) and potential clinical utility for earlier and cost-effective diagnosis if combined with magnetic resonance imaging 22 .…”