2000
DOI: 10.1590/s0074-02762000000400015
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Genomic rearrangements in trypanosomatids: an alternative to the "one gene" evolutionary hypotheses?

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Cited by 25 publications
(23 citation statements)
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References 45 publications
(57 reference statements)
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“…Similarly, this finding was observed with MLP (R 2 = -0.938) and the MLP for persons ≥ 40 years of age (R 2 = -0.960). By linking these observations to the theory of an Amazonian origin of TL 2 and other studies that that support this theory, 19,20,[31][32][33] we can speculate on the parasite-host coevolutionary mechanisms. Human populations in certain geographic areas may be more susceptible to Leishmania because of parasite introductions or reintroductions in more recent periods.…”
Section: Discussionmentioning
confidence: 52%
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“…Similarly, this finding was observed with MLP (R 2 = -0.938) and the MLP for persons ≥ 40 years of age (R 2 = -0.960). By linking these observations to the theory of an Amazonian origin of TL 2 and other studies that that support this theory, 19,20,[31][32][33] we can speculate on the parasite-host coevolutionary mechanisms. Human populations in certain geographic areas may be more susceptible to Leishmania because of parasite introductions or reintroductions in more recent periods.…”
Section: Discussionmentioning
confidence: 52%
“…If over time the interaction mechanisms of the parasite with hosts and vectors lead to decreased manifestation of the more severe clinical forms of the disease, as occurs with urban CL in the Middle East, humans already considered a source of infection are likely to become a reservoir of L. ( V. ) braziliensis . 2,31,35 However, evidence that humans may be reservoirs of L. ( V. ) braziliensis is still limited to xenodiagnosis of Phlebotominae on the borders of skin lesions. 34 Our findings show the need for further research to elucidate factors that modify clinical manifestations of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…Once, the Leishmania -like parasites of reptiles were recognized as a separate genus L. ( Sauroleishmania ) [5,6]. But the classification of lizard Leishmania as subgenus L .…”
Section: Introductionmentioning
confidence: 99%
“…According to the absolute chromosomal size difference index (aCSDI) analysis of as many as 31 “conserved” chromosomes, subgenera L . ( Leishmania ) is divided into clusters: (1) Old world representatives of subgenus Leishmania (OWL), and (2) New world representatives of subgenus Leishmania (NWL) and subgenus Viannia (NWV) [6]. …”
Section: Introductionmentioning
confidence: 99%
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