Genomic profiling of extended-spectrum β-lactamase-producing Escherichia coli from Pets in the United Arab Emirates: Unveiling colistin resistance mediated by mcr-1.1 and its probable transmission from chicken meat – A One Health perspective

Habib, Ihab; Elbediwi, Mohammed; Mohteshamuddin, Khaja; Mohamed, Mohamed-Yousif Ibrahim; Lakshmi, Glindya Bhagya; Abdalla, Afra; Anes, Febin; Ghazawi, Akela; Khan, Mushtaq; Khalifa, Hazim

doi:10.1016/j.jiph.2023.10.034

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Particularly worrisome is the use of low prophylactic doses of antibiotics in animals, as it can lead to the development of antibiotic-resistant bacteria during the preparation or consumption of animal-derived foods [ 94 ]. Extensive documentation confirms that humans can acquire drug-resistant bacteria, including strains like E. coli , Salmonella , Campylobacter , and Staphylococcus , through the consumption of animal-derived foods [ 105 , 106 , 107 ]. Furthermore, certain drugs, such as fluoroquinolones and avoparcin, have been demonstrated to contribute to the emergence of antibiotic-resistant bacteria in animal-origin food sources [ 108 ].…”

Section: Public Health Impactsmentioning

confidence: 99%

“…The widespread use of antibiotics in animal feed, even for prevention as noted by Allen (2014), contaminates the environment and contributes to the development of antibiotic-resistant microorganisms [ 111 ]. Numerous researchers suggest these resistant bacteria are primarily transmitted to humans through contaminated animal products or environmentally polluted water sources [ 106 , 107 , 110 ].…”

Section: Public Health Impactsmentioning

confidence: 99%

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Veterinary Drug Residues in the Food Chain as an Emerging Public Health Threat: Sources, Analytical Methods, Health Impacts, and Preventive Measures

Khalifa,

Shikoray,

Mohamed

et al. 2024

Foods

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Veterinary medications are necessary for both contemporary animal husbandry and food production, but their residues can linger in foods obtained from animals and pose a dangerous human risk. In this review, we aim to highlight the sources, occurrence, human exposure pathways, and human health effects of drug residues in food-animal products. Following the usage of veterinary medications, pharmacologically active compounds known as drug residues can be found in food, the environment, or animals. They can cause major health concerns to people, including antibiotic resistance development, the development of cancer, teratogenic effects, hypersensitivity, and disruption of normal intestinal flora. Drug residues in animal products can originate from variety of sources, including water or food contamination, extra-label drug use, and ignoring drug withdrawal periods. This review also examines how humans can be exposed to drug residues through drinking water, food, air, and dust, and discusses various analytical techniques for identifying these residues in food. Furthermore, we suggest some potential solutions to prevent or reduce drug residues in animal products and human exposure pathways, such as implementing withdrawal periods, monitoring programs, education campaigns, and new technologies that are crucial for safeguarding public health. This review underscores the urgency of addressing veterinary drug residues as a significant and emerging public health threat, calling for collaborative efforts from researchers, policymakers, and industry stakeholders to develop sustainable solutions that ensure the safety of the global food supply chain.

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Section: Public Health Impactsmentioning

confidence: 99%

Section: Public Health Impactsmentioning

confidence: 99%

Veterinary Drug Residues in the Food Chain as an Emerging Public Health Threat: Sources, Analytical Methods, Health Impacts, and Preventive Measures

Khalifa,

Shikoray,

Mohamed

et al. 2024

Foods

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“…The widespread use of antibiotics in the poultry industry has led to the emergence of widely resistant avian E. coli [2,3]. E. coli can enter the environment via animal feces and can spread through feedlot sheds, soil, air, and even water [4], while transmission through animals used in food production is another important route of E. coli transmission to humans [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Characteristics, Whole-Genome Sequencing and Pathogenicity Analysis of Escherichia coli from a White Feather Broiler Farm

Wu,

Cui,

Han

et al. 2023

Microorganisms

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Avian colibacillosis, caused by avian Escherichia coli (E. coli), has historically been one of the most prevalent infectious diseases in large-scale poultry production, causing growth delays and mortality in chickens, resulting in huge economic losses. In recent years, the widespread use of antibiotics has led to the emergence of multidrug resistance in E. coli as a significant global problem and long-term challenge. Resistant E. coli can be transmitted to humans through animal products or the environment, which presents significant public health concerns and food safety issues. In this study, we analyzed the features of 135 E. coli strains obtained from a white feather broiler farm in Shandong, China, including antimicrobial susceptibility tests, detection of class 1 integrons, drug resistance genes, virulence genes, and phylogenetic subgroups. It is particularly worrying that all 135 E. coli strains were resistant to at least five antibiotic agents, and 100% of them were multidrug-resistant (MDR). Notably, the resistance genes of blaTEM, blaCTX-M, qnrS, aaC4, tetA, and tetB exhibited a high prevalence of carriage among the tested resistance genes. However, mcr-2~mcr-9 were not detected, while the prevalence of mcr-1 was found to be 2.96%. The most common virulence genes detected were EAST1 (14.07%, encoding enterotoxins) and fyuA (14.81%, encoding biofilm formation). Phylogenetic subgroup analysis revealed that E. coli belonging to groups B2 and D, which are commonly associated with high virulence, constituted 2.22% and 11.11%, respectively. The positive rate of class 1 integrons was 31.1%. Whole-genome sequencing (WGS) and animal experiments were performed on a unique isolated strain called 21EC78 with an extremely strong membrane-forming capacity. The WGS results showed that 21EC78 carried 11 drug resistance genes and 16 virulence genes. Animal experiments showed that intraperitoneal injection with 2 × 105 CFU could cause the death of one-day-old SPF chickens in 3 days. However, the mortality of Luhua chickens was comparatively lower than that of SPF chickens. This study reports the isolation of multidrug-resistant E. coli strains in poultry, which may pose a potential threat to human health via the food chain. Furthermore, the findings of this study enhance our comprehension of the frequency and characteristics of multidrug-resistant E. coli in poultry farms, emphasizing the urgent need for improved and effective continuous surveillance to control its dissemination.

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Genomics Characterization of Colistin Resistant Escherichia coli from Chicken Meat—the First Report in the United Arab Emirates

Habib,

Mohamed,

Elbediwi

et al. 2024

Foodborne Pathogens and Disease

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Genomic profiling of extended-spectrum β-lactamase-producing Escherichia coli from Pets in the United Arab Emirates: Unveiling colistin resistance mediated by mcr-1.1 and its probable transmission from chicken meat – A One Health perspective

Cited by 4 publications

References 34 publications

Veterinary Drug Residues in the Food Chain as an Emerging Public Health Threat: Sources, Analytical Methods, Health Impacts, and Preventive Measures

Veterinary Drug Residues in the Food Chain as an Emerging Public Health Threat: Sources, Analytical Methods, Health Impacts, and Preventive Measures

Characteristics, Whole-Genome Sequencing and Pathogenicity Analysis of Escherichia coli from a White Feather Broiler Farm

Genomics Characterization of Colistin Resistant Escherichia coli from Chicken Meat—the First Report in the United Arab Emirates

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