Genomic profile of the plants with pharmaceutical value

Abstract

There is an ample genetic diversity of plants with medicinal importance around the globe and this pool of genetic variation serves as the base for selection as well as for plant improvement. Thus, identification, characterization and documentation of the gene pool of medicinal plants are essential for this purpose. Genomic information of many a medicinal plant species has increased rapidly since the past decade and genetic resources available for domestication and improvement programs include genome sequencing, expressed sequence tags sequencing, transcript profiling, gene transmit, molecular markers in favor of mapping and breeding. In recent years, multiple endeavors have been undertaken for genomic characterization of medicinal plant species with the aid of molecular markers for sustainable utilization of gene pool, its conservation and future studies. Recent advancement in genomics is so fast that only some researches have been published till date and to a large extent documentation is restricted to electronic resources. Whole genome profiling of the identified medicinal plant species, carried out by several researchers, based on the DNA fingerprinting, is well documented in the present review. This review will facilitate preparing a database of the widely used, economically important medicinal plant species, based on their genomic organization.

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

“…To show consistency in the species and pharmacological molecules from natural products, bio-farming can be used to ensure consistency after the traditional species have been authenticated through DNA barcoding [ 86 ]. Markers developed from species through genomic techniques can be incorporated into DNA chips to provide an effective, high-throughput tool for genotyping and also plant species authentication [ 78 , 87 ]. Gene expression using microarray analysis is an innovative transcriptomic technology that allows a fast and effective analysis of many transcripts [ 78 , 88 , 89 ].…”

Neoteric trends in tissue culture-mediated biotechnology of Indian ipecac [Tylophora indica (Burm. f.) Merrill]

“…Clonal fidelity assessment is imperative for large-scale in vitro propagation of any medicinally important plant. Not only for meeting the commercial demand, but also for in vitro conservation of germplasm escaping the detrimental effect of somaclonal variations, post-organogenic evaluation of genetic trueness is indispensable (Gantait et al 2014a). The somaclonal variation is considered as the usual drawback amongst in vitro regenerated plantlets, which might be owing to gene augmentation, chromosomal aberrations, point mutation, and modification in DNA methylation through in vitro culture (Saker et al 2000).…”

Strategies and Techniques of Drug Discovery from Natural Products

“…The use of biofarming will provide consistency after identifying the desired natural species using DNA barcoding technique (Pulice G., 2016). Bio-markers that are formed by using genomic methods can also be combined with DNA chips to spread a good and effective tool up for authentication of the natural products species (Gantait S., 2014). Another very innovative method is called Gene expression through microarray, which allows a quick and precise analysis of a number of transcripts (Lv C., 2017), (Lee K.-H., 2014).…”