Genomic organization and hypoxia inducible factor responsive regulation of teleost hsp90β gene during hypoxia stress

Barman, Hirak Kumar; Mohapatra, SD; Chakrapani, Vemulawada; Mondal, Subhajit; Murmu, Binita; Soren, Meenati Manjari; Patra, Kananbala; Swain, Roy

doi:10.1007/s11033-021-06657-7

Cited by 2 publications

(1 citation statement)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, RMP, along with HSP90AB1 and HSP90AA, may be involved in regulating protein expression. Hypoxia-inducible factor-(HIF-) 1α is a master transcriptional factor for angiogenesis during cardiac repair, and Hsp90 has been reported to stabilize HIF-1α [27,28]. The binding between RMP and HSP90 observed in our study may also indicate that RMP participates in the regulation of HIF-1α expression after MI.…”

Section: Discussionsupporting

confidence: 55%

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice

Zhang

Yin

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Background. Inflammation plays important roles during myocardial infarction (MI). Macrophage polarization is a major factor that drives the inflammatory process. Our previous study found that RNA polymerase II subunit 5-mediating protein (RMP) knockout in cardiomyocytes caused heart failure by impairing mitochondrial structure and function. However, whether macrophage RMP plays a role in MI has not been investigated. Methods. Macrophage RMP-knockout in combination with a mouse model of MI was used to study the function of macrophage RMP in MI. Next, we modified bone marrow-derived macrophages (BMDMs) by plasmid transfection, and the BMDMs were administered to LysM-Cre/DTR mice by tail vein injection. Immunoblotting and immunofluorescence were used to detect macrophage polarization, fibrosis, angiogenesis, and the p38 signaling pathway in each group. Results. Macrophage RMP deficiency aggravates cardiac dysfunction, promotes M1 polarization, and inhibits angiogenesis after MI. However, RMP overexpression in macrophages promotes M2 polarization and angiogenesis after MI. Mechanistically, we found that RMP regulates macrophage polarization through the heat shock protein 90– (HSP90–) p38 signaling pathway. Conclusions. Macrophage RMP plays a significant role in MI, likely by regulating macrophage polarization via the HSP90–p38 signaling pathway.

show abstract

Section: Discussionsupporting

confidence: 55%

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice

Zhang

Yin

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

Multiomics analyses provide insights into the genomic basis of differentiation among four sweet osmanthus groups

Li,

Zhao,

Xia

et al. 2024

Plant Physiology

View full text Add to dashboard Cite

Sweet osmanthus (Osmanthus fragrans) is famous in China for its flowers and contains four groups: Albus, Luteus, Aurantiacus, and Asiaticus. Understanding the relationships among these groups and the genetic mechanisms of flower color and aroma biosynthesis are of tremendous interest. In this study, we sequenced representative varieties from two of the four sweet osmanthus groups. Multi-omic and phylogenetic analyses of varieties from each of the four groups showed that Asiaticus split first within the species, followed by Aurantiacus and the sister groups Albus and Luteus. We show that the difference in flower color between Aurantiacus and the other three groups was caused by a 4-bp deletion in the promoter region of carotenoid cleavage dioxygenase 4 (OfCCD4) that leads to expression decrease. In addition, we identified 44 gene pairs exhibiting significant structural differences between the multi-seasonal flowering variety ‘Rixianggui’ in the Asiaticus group and other autumn flowering varieties. Through correlation analysis between intermediate products of aromatic components and gene expression, we identified eight genes associated with the linalool, α- and β-ionone biosynthesis pathways. Overall, our study offers valuable genetic resources for sweet osmanthus, while also providing genetic clues for improving the flower color and multi-season flowering of osmanthus and other flowers.

show abstract

Genomic organization and hypoxia inducible factor responsive regulation of teleost hsp90β gene during hypoxia stress

Cited by 2 publications

References 50 publications

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice

Macrophage Rmp Ameliorates Myocardial Infarction by Modulating Macrophage Polarization in Mice

Multiomics analyses provide insights into the genomic basis of differentiation among four sweet osmanthus groups

Contact Info

Product

Resources

About