Genomic mutations after multigenerational exposure of Caenorhabditis elegans to pristine and sulfidized silver nanoparticles

Wamucho, Anye; Unrine, Jason M.; Kieran, Troy J.; Glenn, Travis C.; Schultz, Carolin; Farman, Mark L.; Svendsen, Claus; Spurgeon, David J.; Tsyusko, Olga V.

doi:10.1016/j.envpol.2019.113078

Cited by 32 publications

(22 citation statements)

References 48 publications

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“…Moon et al [118] showed that the presence of different silver nanomaterials (including nanoparticles) in the soil decreased the growth and reproduction of C. elegans. Similarly, in another study, the hereditary reproductive toxicity produced by Ag-NPs in C. elegans was demonstrated and it was observed that this toxicity contributed to inducing germline mutations [116,119].…”

Section: Humansmentioning

confidence: 76%

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

et al. 2020

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Foodborne diseases are one of the factors that endanger the health of consumers, especially in people at risk of exclusion and in developing countries. The continuing search for effective antimicrobials to be used in the food industry has resulted in the emergence of nanotechnology in this area. Silver nanoparticles (Ag-NPs) are the nanomaterial with the best antimicrobial activity and therefore, with great potential of application in food processing and packing. However, possible health effects must be properly addressed to ensure food safety. This review presents a detailed description on the main applications of Ag-NPs as antimicrobial agents for food control, as well as the current legislation concerning these materials. Current knowledge about the impact of the dietary exposure to Ag-NPs in human health with special emphasis on the changes that nanoparticles undergo after passing through the gastrointestinal tract and how they alter the oral and gut microbiota, is also summarized. It is concluded that given their potential and wide properties against foodborne pathogens, research in Ag-NPs is of great interest but is not exempt from difficulties that must be resolved in order to certify the safety of their use.

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Section: Humansmentioning

confidence: 76%

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

et al. 2020

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“…Recent studies in Caenorhabditis elegans also showed that chronic exposures to environmental pollutants cause an increased number of mutations, deletions, and insertions, even ten generations further. Intermediate epigenetic mechanisms were suggested, but the exact mechanisms have not been explored yet [102].…”

Section: Discussionmentioning

confidence: 99%

Transgenerational epigenetic effects from male exposure to endocrine-disrupting compounds: a systematic review on research in mammals

et al. 2020

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Assessing long-term health effects from a potentially harmful environment is challenging. Endocrine-disrupting compounds (EDCs) have become omnipresent in our environment. Individuals may or may not experience clinical health issues from being exposed to the increasing environmental pollution in daily life, but an issue of high concern is that also the non-exposed progeny may encounter consequences of these ancestral exposures. Progress in understanding epigenetic mechanisms opens new perspectives to estimate the risk of man-made EDCs. However, the field of epigenetic toxicology is new and its application in public health or in the understanding of disease etiology is almost non-existent, especially if it concerns future generations. In this review, we investigate the literature on transgenerational inheritance of diseases, published in the past 10 years. We question whether persistent epigenetic changes occur in the male germ line after exposure to synthesized EDCs. Our systematic search led to an inclusion of 43 articles, exploring the effects of commonly used synthetic EDCs, such as plasticizers (phthalates and bisphenol A), pesticides (dichlorodiphenyltrichloroethane, atrazine, vinclozin, methoxychlor), dioxins, and polycyclic aromatic hydrocarbons (PAHs, such as benzo(a)pyrene). Most studies found transgenerational epigenetic effects, often linked to puberty-or adult-onset diseases, such as testicular or prostate abnormalities, metabolic disorders, behavioral anomalies, and tumor development. The affected epigenetic mechanisms included changes in DNA methylation patterns, transcriptome, and expression of DNA methyltransferases. Studies involved experiments in animal models and none were based on human data. In the future, human studies are needed to confirm animal findings. If not transgenerational, at least intergenerational human studies and studies on EDCinduced epigenetic effects on germ cells could help to understand early processes of inheritance. Next, toxicity tests of new chemicals need a more comprehensive approach before they are introduced on the market. We further point to the relevance of epigenetic toxicity tests in regard to public health of the current population but also of future generations. Finally, this review sheds a light on how the interplay of genetics and epigenetics may explain the current knowledge gap on transgenerational inheritance.

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“…At present, no more than thirty chemical agents (only four of those are considered as environmental pollutants), have had their mutagenicity directly assessed with next generation sequencing (NGS) technology (Beal et al, 2019; Bull et al, 2019; Du et al, 2017; Wamucho et al, 2019). Each year, around 50,000 to 100,000 chemical substances are registered in the European Union.…”

Section: Introductionmentioning

confidence: 99%

Measuring mutagenicity in ecotoxicology: A case study of Cd exposure inChironomus riparius

Doria

Waldvogel

Pfenninger

2020

Preprint

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Existing mutagenicity tests for metazoans lack the direct observation of enhanced germline mutation rates after exposure to anthropogenic substances, therefore being inefficient. Cadmium (Cd) is a metal described as a mutagen in mammalian cells and listed as a group 1 carcinogenic and mutagenic substance. But Cd mutagenesis mechanism is not yet clear. Therefore, in the present study, we propose a method coupling short-term mutation accumulation (MA) lines with subsequent whole genome sequencing (WGS) and a dedicated data analysis pipeline to investigate if chronic Cd exposure on Chironomus riparius can alter the rate at which de novo point mutations appear. Results show that Cd exposure did not affect the basal germline mutation rate nor the mutational spectrum in C. riparius, thereby arguing that exposed organisms might experience a range of other toxic effects before any mutagenic effect may occur. We show that it is possible to establish a practical and easily implemented pipeline to rapidly detect germ cell mutagens in a metazoan test organism. Furthermore, our data implicate that it is questionable to transfer mutagenicity assessments based on in vitro methods to complex metazoans.

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Genomic mutations after multigenerational exposure of Caenorhabditis elegans to pristine and sulfidized silver nanoparticles

Cited by 32 publications

References 48 publications

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

Silver Nanoparticles against Foodborne Bacteria. Effects at Intestinal Level and Health Limitations

Transgenerational epigenetic effects from male exposure to endocrine-disrupting compounds: a systematic review on research in mammals

Measuring mutagenicity in ecotoxicology: A case study of Cd exposure inChironomus riparius

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