Abstract:Herpes simplex virus 1 (HSV-1) is a significant pathogen that establishes life-long latent infections with intermittent episodes of resumed disease. In mouse models of HSV infection, persistent low-level lytic gene expression has been detected during latency in the absence of spontaneous reactivation events leading to new virus production. This viral activity during latency has been reported using a sensitive Cre-marking model for several lytic gene promoters placed in one location in the HSV-1 genome. Here we… Show more
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