Abstract:SummaryBackgroundEffective targeted therapy for sepsis requires an understanding of the heterogeneity in the individual host response to infection. We investigated this heterogeneity by defining interindividual variation in the transcriptome of patients with sepsis and related this to outcome and genetic diversity.MethodsWe assayed peripheral blood leucocyte global gene expression for a prospective discovery cohort of 265 adult patients admitted to UK intensive care units with sepsis due to community-acquired … Show more
“…The future of sepsis therapy may yet lie with protocols that permit a more individualized approach that is based on a greater understanding of the complex interplay among host genetics, individual pathophysiological features, and the infective agent. [18][19][20] …”
“…The future of sepsis therapy may yet lie with protocols that permit a more individualized approach that is based on a greater understanding of the complex interplay among host genetics, individual pathophysiological features, and the infective agent. [18][19][20] …”
“…Triage is performed by this computerized system, with patients being admitted to the ICU only if data indicate that they will respond to treatment: if their telomeres demonstrate a tendency for longevity [3], their genetic testing demonstrates that they are not likely to develop non-iatrogenic complications; e.g. ARDS [4] sepsis [5], renal failure [6]) and their streaming merged physiological data trend suggest a good likelihood of response to therapy [7].…”
Section: "Prediction Is Very Difficult Especially About the Future"mentioning
“…A recent study in patients with community-acquired pneumonia examining gene-expression profiles identified a subgroup of patients who had an immunesuppressed phenotype and higher mortality rate than patients without the immuno-suppression [93]. Such immunosuppressed patients may benefit from treatment with immunostimulant therapies such as IL-7 (NCT02640807), anti-PDL1 and other immuno-stimulating interventions [94].…”
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